Patents Assigned to ACS Dobfar S.p.A.
  • Injectable sterile pharmaceutical composition with piperacillin sodium and tazobactam sodium as active principles
    Patent number: 8765190
    Abstract: A sterile pharmaceutical composition having as its active principles piperacillin sodium and tazobactam sodium of substantially the same density, mixed with sodium bicarbonate. The mixture is soluble in water to give injectable reconstituted solutions having high stability with time.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: July 1, 2014
    Assignee: ACS Dobfar S.p.A.
    Inventors: Angelo Giovanni Cattaneo, Leonardo Marsili
  • 1,3 imidazolidine derivatives and their use in the production of carbapenem
    Patent number: 8383661
    Abstract: Preparation of new heterocyclic compounds characterized by 1,3-imidazolidine structure useful for stereoselective synthesis of optically pure key intermediates in 1?-methylcarbapenem production.
    Type: Grant
    Filed: October 1, 2009
    Date of Patent: February 26, 2013
    Assignee: ACS DOBFAR S.p.A.
    Inventors: Mauro Freccero, Giovanni Fogliato, Antonio Manca, Michele Bassanini
  • Process for producing 7-methoxy-3-desacetylcefalotin
    Patent number: 8067195
    Abstract: The invention relates to a method for preparing 7-methoxy-3-desacetylcefalotin by a hydrolysis process which takes place in water and is catalyzed by an enzyme obtained from Bacillus pumulis possessing acetyl hydrolasic activity.
    Type: Grant
    Filed: August 15, 2008
    Date of Patent: November 29, 2011
    Assignee: ACS Dobfar S.p.A.
    Inventors: Auro Roberto Tagliani, Gabriele Guastalegname, Giovanni Fogliato, Riccardo Monguzzi
  • Injectable sterile pharmaceutical formulation containing at least two active principles
    Patent number: 7964589
    Abstract: Mixtures of at least two active principles, of which at least one is the sodium salt, are precipitated from an organic solution containing the same active principles in salified or non-salified acid form.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: June 21, 2011
    Assignee: ACS Dobfar S.p.A.
    Inventors: Maurizio Zenoni, Angelo Giovanni Cattaneo, Leonardo Marsili
  • 1,3 IMIDAZOLIDINE DERIVATIVES AND THEIR USE IN THE PRODUCTION OF CARBAPENEM
    Publication number: 20110015389
    Abstract: Preparation of new heterocyclic compounds characterised by 1,3-imidazolidine structure useful for stereoselective synthesis of optically pure key intermediates in 1?-methylcarbapenem production
    Type: Application
    Filed: October 1, 2009
    Publication date: January 20, 2011
    Applicant: ACS DOBFAR S.p.A.
    Inventors: Mauro Freccero, Giovanni Fogliato, Antonio Manca, Michele Bassanini
  • Purification of beta-lactam products
    Patent number: 7728126
    Abstract: Method for purifying 7?-methoxy-cephalosporins containing as impurity the corresponding 7?-methylthio analogue, which is transformed into its methoxy analogue by treatment with a halogenating agent in methanol. In this way the complete conversion of the sulphurated impurity into the corresponding methoxy analogue is obtained.
    Type: Grant
    Filed: August 17, 2006
    Date of Patent: June 1, 2010
    Assignee: ACS DOBFAR S.p.A.
    Inventors: Giovanni Fogliato, Marco Forzatti, Maurizio Zenoni
  • PROCESS FOR SYNTHESIZING CARBAPENEM USING RANEY NICKEL
    Publication number: 20100004463
    Abstract: Convenient method for obtaining carbapenem by hydrogenation with Raney Nickel, as an alternative to the known catalytic hydrogenation conducted under hydrogen overpressure in the presence of Palladium, starting from corresponding protected intermediates such as p-nitrobenzylesters and with optional suitable protections of any primary and secondary amino functions structurally present.
    Type: Application
    Filed: June 25, 2009
    Publication date: January 7, 2010
    Applicant: ACS DOBFAR S.p.A.
    Inventors: Antonio MANCA, Riccardo Ambrogio Monguzzi
  • Crystalline solvate of cefuroxime acid
    Patent number: 7615631
    Abstract: Crystalline acetonitrile solvate of cefuroxime acid, useful for preparing the antibiotic cefuroxime sodium salt.
    Type: Grant
    Filed: April 18, 2006
    Date of Patent: November 10, 2009
    Assignee: ACS Dobfar S.p.A.
    Inventors: Maurizio Zenoni, Angelo Giovanni Cattaneo
  • Process for preparing sodium cefoxitin
    Patent number: 7605256
    Abstract: Cefalotin is methoxylated in position 7?, desacetylated and then carbamoylated in position 3, to provide acid cefoxitin without any isolation of intermediate products. The acid cefoxitin is then transformed into the sodium salt by means of ion exchange resin.
    Type: Grant
    Filed: June 21, 2006
    Date of Patent: October 20, 2009
    Assignee: ACS DOBFAR S.p.A.
    Inventors: Antonio Manca, Riccardo Monguzzi, Maurizio Zenoni, Leonardo Marsili
  • Process for obtaining cefotetan with high yield
    Patent number: 7560545
    Abstract: The invention relates to a method for obtaining cefotetan acid substantially free of tautomer, by treating crude cefotetan with Al3+ ions which cause the tautomer to precipitate. The precipitate is eliminated by filtration to provide a solution from which practically tautomer-free cefotetan is obtained.
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: July 14, 2009
    Assignee: ACS Dobfar S.p.A.
    Inventors: Maurizio Zenoni, Antonio Manca, Riccardo Monguzzi
  • PROCESS FOR PRODUCING 7-METHOXY-3-DESACETYLCEFALOTIN
    Publication number: 20090093032
    Abstract: Process for producing 7-methoxy-3-desacetylcefalotin by a hydrolysis process which takes place in water and is catalyzed by an enzyme. Cefoxitin can be obtained from this compound by known methods.
    Type: Application
    Filed: August 15, 2008
    Publication date: April 9, 2009
    Applicant: ACS DOBFAR S.p.A
    Inventors: Auro Roberto TAGLIANI, Gabriele Guastalegname, Giovanna Fogliato, Riccardo Monguzzi
  • Process for producing Cefepime and cephalosporin analogues
    Patent number: 7479556
    Abstract: Process for producing Cefepime, Cefpirome and Cefquinome, whereby a cephalosporin containing a quaternary ammonium group is reacted with thiourea to provide the aforesaid cephalosporins.
    Type: Grant
    Filed: September 9, 2005
    Date of Patent: January 20, 2009
    Assignee: ACS Dobfar S.p.A.
    Inventors: Antonio Manca, Riccardo Monguzzi, Maurizio Zenoni, Leonardo Marsili
  • INJECTABLE STERILE PHARMACEUTICAL COMPOSITION WITH PIPERACILLIN SODIUM AND TAZOBACTAM SODIUM AS ACTIVE PRINCIPLES
    Publication number: 20080233196
    Abstract: A sterile pharmaceutical composition having as its active principles piperacillin sodium and tazobactam sodium of substantially the same density, mixed with sodium bicarbonate. The mixture is soluble in water to give injectable reconstituted solutions having high stability with time.
    Type: Application
    Filed: December 6, 2007
    Publication date: September 25, 2008
    Applicant: ACS DOBFAR S.p.A.
    Inventors: Angelo Giovanni CATTANEO, Leonardo Marsili
  • Bag for preserving and transporting sterile products in powder form and for forming solutions of said products in the bag
    Patent number: 7244247
    Abstract: A bag for preserving and transporting a sterile product in powder form and a method for preparing solutions of the sterile product in the bag. The bag contains a sterile product in powder form and has a port closed by a membrane through which a solvent can be fed into the bag to form a sterile solution of the powder. Further, the bag contains an amount of the sterile product in powder form adapted to give with the solvent and within the bag a reconstituted ready to use solution that only partially fills a capacity of the bag.
    Type: Grant
    Filed: April 23, 1999
    Date of Patent: July 17, 2007
    Assignee: ACS Dobfar S.p.A.
    Inventors: Marco Falciani, Sergio Dusci
  • PURIFICATION OF BETA-LACTAM PRODUCTS
    Publication number: 20070093657
    Abstract: Method for purifying 7?-methoxy-cephalosporins containing as impurity the corresponding 7?-methylthio analogue, which is transformed into its methoxy analogue by treatment with a halogenating agent in methanol. In this way the complete conversion of the sulphurated impurity into the corresponding methoxy analogue is obtained.
    Type: Application
    Filed: August 17, 2006
    Publication date: April 26, 2007
    Applicant: ACS DOBFAR S.p.A.
    Inventors: Giovanni FOGLIATO, Marco Forzatti, Maurizio Zenoni
  • Injectable sterile pharmaceutical formulation containing at least two active principles
    Publication number: 20070054889
    Abstract: Mixtures of at least two active principles, of which at least one is the sodium salt, are precipitated from an organic solution containing the same active principles in salified or non-salified acid form.
    Type: Application
    Filed: July 27, 2006
    Publication date: March 8, 2007
    Applicant: ACS DOBFAR S.p.A.
    Inventors: Maurizio Zenoni, Angelo Cattaneo, Leonardo Marsili
  • PROCESS FOR PREPARING SODIUM CEFOXITIN
    Publication number: 20070027314
    Abstract: Cefalotin is methoxylated in position 7?, desacetylated and then carbamoylated in position 3, to provide acid cefoxitin without any isolation of intermediate products. The acid cefoxitin is then transformed into the sodium salt by means of ion exchange resin.
    Type: Application
    Filed: June 21, 2006
    Publication date: February 1, 2007
    Applicant: ACS DOBFAR S.p.A.
    Inventors: Antonio MANCA, Riccardo MONGUZZI, Maurizio ZENONI, Leonardo MARSILI
  • Acid cefotetan totally solvent-free and method for obtaining same
    Publication number: 20060281915
    Abstract: The invention relates to a method for obtaining cefotetan acid substantially free of tautomer, by initial isolation of the crude product with a limited tautomer content, followed by purification through a chromatographic column. The invention also concerns the acid cefotetan totally solvent-free thereby obtained.
    Type: Application
    Filed: April 25, 2006
    Publication date: December 14, 2006
    Applicant: ACS DOBFAR S.p.A.
    Inventors: Maurizio Zenoni, Alessandro Donadelli
  • PROCESS FOR OBTAINING CEFOTETAN WITH HIGH YIELD
    Publication number: 20060281916
    Abstract: The invention relates to a method for obtaining cefotetan acid substantially free of tautomer, by treating crude cefotetan with Al3+ ions which cause the tautomer to precipitate. The precipitate is eliminated by filtration to provide a solution from which practically tautomer-free cefotetan is obtained.
    Type: Application
    Filed: May 12, 2006
    Publication date: December 14, 2006
    Applicant: ACS DOBFAR S.p.A.
    Inventors: Maurizio ZENONI, Antonio MANCA, Riccardo MONGUZZI
  • CRYSTALLINE SOLVATE OF CEFUROXIME ACID
    Publication number: 20060258636
    Abstract: Crystalline Solvate of cefuroxime acid, useful for preparing the antibiotic cefuroxime sodium salt.
    Type: Application
    Filed: April 18, 2006
    Publication date: November 16, 2006
    Applicant: ACS DOBFAR S.p.A.
    Inventors: Maurizio ZENONI, Angelo Cattaneo