Patents Assigned to Actavis Group PTC EHF
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Patent number: 10441536Abstract: Described herein are micronized powder particles of colistimethate sodium wherein at least 50% by volume of the micronized particles have a diameter of less than 7 micrometers but not less than 3 micrometers and the powder has a total moisture content of from 5 to 10% by weight, for use in the treatment of a pulmonary infection by powder inhalation, wherein the colistimethate sodium is not separated into component form. The micronized powder particles of colistimethate sodium are useful in the treatment of infections caused by gram-negative bacteria, particularly in patients suffering from cystic fibrosis.Type: GrantFiled: March 7, 2014Date of Patent: October 15, 2019Assignee: ACTAVIS GROUP PTC EHFInventors: Richard Anthony Flynn, Rahul Surana, Anil Chhettry, David Farrington, Ritesh Sanghvi
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Patent number: 9512060Abstract: Provided herein are novel solid state forms of tapentadol salts, process for their preparation, pharmaceutical compositions, and method of treating thereof. The tapentadol salts include an L-(?)-camphorsulfonate salt, a dibenzoyl-(L)-tartrate salt, a dibenzoyl-(D)-tartrate salt, a malate salt, a maleate salt, or a salicylate salt.Type: GrantFiled: February 5, 2015Date of Patent: December 6, 2016Assignee: ACTAVIS GROUP PTC EHFInventors: Mayur Devjibhai Khunt, Sandipan Prabhurao Bondge, Vikas Daulatrao Ahirao, Nitin Sharadchandra Pradhan
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Patent number: 9006443Abstract: Disclosed herein is an improved, commercially viable and industrially advantageous process for the preparation of quinoline-3-carboxamide derivatives such as laquinimod, or a pharmaceutically acceptable salt thereof, in high yield and purity.Type: GrantFiled: September 9, 2013Date of Patent: April 14, 2015Assignee: Actavis Group PTC ehfInventors: Girish Dixit, Krishnadatt Sharma, Kundan Singh Shekhawat, Nitin Sharadchandra Pradhan, Jon Valgeirsson
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Patent number: 8981154Abstract: Provided herein are novel solid state forms of tapentadol salts, process for their preparation, pharmaceutical compositions, and method of treating thereof. The tapentadol salts include an L-(?)-camphorsulfonate salt, a dibenzoyl-(L)-tartrate salt, a dibenzoyl-(D)-tartrate salt, a malate salt, a maleate salt, or a salicylate salt.Type: GrantFiled: September 11, 2012Date of Patent: March 17, 2015Assignee: Actavis Group PTC EHFInventors: Mayur Devjibhai Khunt, Sandipan Prabhurao Bondge, Nitin Sharadchandra Pradhan, Depashri Vikas Ahirao
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Patent number: 8859769Abstract: Provided herein are improved, commercially viable and industrially advantageous processes for the preparation of a substantially pure ticagrelor intermediate, 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine, Formula (II). The intermediate is useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof in high yield and purity.Type: GrantFiled: February 15, 2011Date of Patent: October 14, 2014Assignee: Actavis Group PTC EHFInventors: Anil Shahaji Khile, Jayesh Patel, Nikhil Trivedi, Nitin Sharadchandra Pradhan
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Publication number: 20140206867Abstract: Disclosed herein is an improved process for the preparation of substituted cyclopentanamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Particularly described is an improved, commercially viable and industrially advantageous process for the preparation of a ticagrelor intermediate, [3aR-(3a?,4?,6?,6a?]-2-[[6-amino-2,2-dimethyltetrahydro-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-ethanol, alternatively named, 2-[[(3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]-dioxol-4-yl]oxy]-1-ethanol.Type: ApplicationFiled: June 13, 2012Publication date: July 24, 2014Applicant: Actavis Group PTC EHFInventors: Anil Shahaji Khile, Vignesh Nair, Nikhil Trivedi, Nitin Sharadchandra Pradhan
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Publication number: 20140005401Abstract: Disclosed herein is an improved, commercially viable and industrially advantageous process for the preparation of quinoline-3-carboxamide derivatives such as laquinimod, or a pharmaceutically acceptable salt thereof, in high yield and purity.Type: ApplicationFiled: September 9, 2013Publication date: January 2, 2014Applicant: ACTAVIS GROUP PTC EHFInventors: Girish Dixit, Krishnadatt Sharma, Kundan Singh Shekhawat, Nitin Sharadchandra Pradhan, Jon Valgeirsson
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Publication number: 20130317220Abstract: Provided herein is a novel process for the preparation of triazolo[4,5-d]pyrimidine derivatives. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of highly pure ticagrelor or a pharmaceutically acceptable salt thereof. Provided further herein is a novel process for the preparation of substituted cyclopentanamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of a ticagrelor intermediate, 2-[[(3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]-dioxol-4-yl]oxy]-1-ethanol.Type: ApplicationFiled: December 16, 2011Publication date: November 28, 2013Applicant: Actavis Group Ptc EhfInventors: Vignesh Nair, Nikhil Trivedi, Anil Shahaji Khile, Nitin Sharadchandra Pradhan
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Patent number: 8552194Abstract: Disclosed herein is an improved, commercially viable and industrially advantageous process for the preparation of quinoline-3-carboxamide derivatives such as laquinimod, or a pharmaceutically acceptable salt thereof, in high yield and purity.Type: GrantFiled: April 27, 2009Date of Patent: October 8, 2013Assignee: Actavis Group PTC EHFInventors: Girish Dixit, Krishnadatt Sharma, Kundan Singh Shekhawat, Nitin Sharadchandra Pradhan, Jon Valgeirsson
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Publication number: 20130165696Abstract: Provided herein are novel processes for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein are novel, commercially viable and industrially advantageous processes for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. Provided further herein are novel acid addition salts of trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine, and process for their preparation. The intermediate and its acid addition salts are useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity.Type: ApplicationFiled: June 28, 2011Publication date: June 27, 2013Applicant: ACTAVIS GROUP PTC EHFInventors: Anil Shahaji Khile, Vignesh Nair, Nikhil Trivedi, Nitin Sharadchandra Pradhan
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Publication number: 20130150577Abstract: Provided herein is a novel process for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. The intermediate is useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity.Type: ApplicationFiled: April 19, 2011Publication date: June 13, 2013Applicant: ACTAVIS GROUP PTC EHFInventors: Anil Shahaji Khile, Jayesh Patel, Nikhil Trivedi, Nitin Sharadchandra Pradhan
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Publication number: 20130101630Abstract: Provided herein is an impurity of varenicline, methylvarenicline, 6-methyl-5,8,14-triazatetracyclo[10.3.1.02,11,04,9]hexadeca-2(11),3,5,7,9-pentaene, and a process for the preparation and isolation thereof. Provided further herein is a highly pure varenicline or a pharmaceutically acceptable salt thereof substantially free of methylvarenicline impurity, processes for the preparation thereof, and pharmaceutical compositions comprising highly pure varenicline or a pharmaceutically acceptable salt thereof substantially free of methylvarenicline impurity.Type: ApplicationFiled: March 8, 2011Publication date: April 25, 2013Applicant: ACTAVIS GROUP PTC EHFInventors: Nitin Sharadchandra Pradhan, Arvapally Seshu Kumar, Nikhil Trivedi, Krishnadatt Sharma
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Publication number: 20130096347Abstract: Provided herein is a novel, commercially viable and industrially advantageous process for the preparation of 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol (Tapentadol), or a pharmaceutically acceptable salt thereof, and its intermediates, in high yield and purity. Provided also herein are novel solid state forms of tapentadol intermediates and processes for their preparation thereof. Provided further herein is a purification process for preparing highly pure tapentadol hydrochloride.Type: ApplicationFiled: April 4, 2011Publication date: April 18, 2013Applicant: ACTAVIS GROUP PTC EHFInventors: Mayur Devjibhai Khunt, Sandipan Prabhurao Bondge, Nilesh Sudhir Patil, Haushabhau Shivaji Pagire, Nitin Sharadchandra Pradhan
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Publication number: 20130096346Abstract: Provided herein is an improved and industrially advantageous optical resolution method for resolving (2R,3R)/(2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol, and use thereof for the preparation of tapentadol or a pharmaceutically acceptable salt thereof. Provided further herein is an improved and industrially advantageous optical resolution method for resolving (2R,3R)/(2S,3S)-[3-(3-methoxyphenyl)-2-methylpentyl]-dimethylamine, and use thereof for the preparation of tapentadol or a pharmaceutically acceptable salt thereof. Disclosed also herein is an improved, commercially viable and industrially advantageous process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof in high yield and purity.Type: ApplicationFiled: March 1, 2011Publication date: April 18, 2013Applicant: ACTAVIS GROUP PTC EHFInventors: Mayur Devjibhai Khunt, Sandipan Prabhurao Bondge, Nitin Sharadchandra Pradhan
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Publication number: 20130090314Abstract: Provided herein are novel solid state forms of tapentadol salts, process for their preparation, pharmaceutical compositions, and method of treating thereof. The tapentadol salts include an L-(?)-camphorsulfonate salt, a dibenzoyl-(L)-tartrate salt, a dibenzoyl-(D)-tartrate salt, a malate salt, a maleate salt, or a salicylate salt.Type: ApplicationFiled: September 11, 2012Publication date: April 11, 2013Applicant: ACTAVIS GROUP PTC EHFInventors: Mayur Devjibhai Khunt, Sandipan Prabhurao Bondge, Nitin Sharadchandra Pradhan, Depashri Vikas Ahirao
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Publication number: 20130072682Abstract: Provided herein is an improved, convenient, commercially viable and environmentally friendly process for the preparation of varenicline or a pharmaceutically acceptable salt thereof comprising reacting 1-(4 ,5-diamino-10-aza-tricyclo[6.3.1.02.7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone with chloroacetaldehyde in the presence of an oxygen source. Provided further herein is an improved and industrially advantageous process for the preparation of 1-(4,5-diamino-10-aza-tricyclo[6.3.1.02.7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone.Type: ApplicationFiled: October 15, 2012Publication date: March 21, 2013Applicant: ACTAVIS GROUP PTC EHFInventors: Actavis Group PTC EHF, Engelbert Seide
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Publication number: 20130030176Abstract: Provided herein are improved, commercially viable and industrially advantageous processes for the preparation of a substantially pure ticagrelor intermediate, 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine, Formula (II). The intermediate is useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof in high yield and purity.Type: ApplicationFiled: February 15, 2011Publication date: January 31, 2013Applicant: ACTAVIS GROUP PTC EHFInventors: Anil Shahaji Khile, Jayesh Patel, Nikhil Trivedi, Nitin Sharadchandra Pradhan
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Patent number: 8354428Abstract: Provided herein is a novel crystalline form of laquinimod, process for the preparation, pharmaceutical compositions, and method of treating thereof. Provided also herein are novel amorphous and polymorphic forms of laquinimod sodium, process for the preparation, pharmaceutical compositions, and method of treating thereof.Type: GrantFiled: June 30, 2009Date of Patent: January 15, 2013Assignee: Actavis Group PTC EHFInventors: Girish Dixit, Krishnadatt Sharma, Nitin Sharadchandra Pradhan, Jon Valgeirsson
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Patent number: 8314235Abstract: Provided herein is an improved, convenient, commercially viable and environmentally friendly process for the preparation of varenicline or a pharmaceutically acceptable salt thereof comprising reacting 1-(4,5-diamino-10-aza-tricyclo[6.3.1.02 7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone with chloroacetaldehyde in the presence of an oxygen source. Provided further herein is an improved and industrially advantageous process for the preparation of 1-(4,5-diamino-10-aza-tricyclo[6.3.1.02 7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone.Type: GrantFiled: August 31, 2009Date of Patent: November 20, 2012Assignee: Actavis Group PTC EHFInventors: Girish Dixit, Krishnadatt Sharma, Kundan Singh Shekhawat, Nitin Sharadchandra Pradhan
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Publication number: 20120269871Abstract: Provided herein are novel crystalline forms of rasagiline salts, processes for their preparation, pharmaceutical compositions, and method of treating thereof. The rasagiline salts include a maleate salt, a mandelate salt, or a salicylate salt.Type: ApplicationFiled: December 29, 2010Publication date: October 25, 2012Applicant: ACTAVIS GROUP PTC EHFInventors: Nilesh Sudhir Patil, Haushabhau Shivaji Pagire, Neela Praveen Kumar, Nitin Sharadchandra Pradhan