Patents Assigned to Actavis Group PTC EHF
  • Patent number: 10441536
    Abstract: Described herein are micronized powder particles of colistimethate sodium wherein at least 50% by volume of the micronized particles have a diameter of less than 7 micrometers but not less than 3 micrometers and the powder has a total moisture content of from 5 to 10% by weight, for use in the treatment of a pulmonary infection by powder inhalation, wherein the colistimethate sodium is not separated into component form. The micronized powder particles of colistimethate sodium are useful in the treatment of infections caused by gram-negative bacteria, particularly in patients suffering from cystic fibrosis.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: October 15, 2019
    Assignee: ACTAVIS GROUP PTC EHF
    Inventors: Richard Anthony Flynn, Rahul Surana, Anil Chhettry, David Farrington, Ritesh Sanghvi
  • Patent number: 9512060
    Abstract: Provided herein are novel solid state forms of tapentadol salts, process for their preparation, pharmaceutical compositions, and method of treating thereof. The tapentadol salts include an L-(?)-camphorsulfonate salt, a dibenzoyl-(L)-tartrate salt, a dibenzoyl-(D)-tartrate salt, a malate salt, a maleate salt, or a salicylate salt.
    Type: Grant
    Filed: February 5, 2015
    Date of Patent: December 6, 2016
    Assignee: ACTAVIS GROUP PTC EHF
    Inventors: Mayur Devjibhai Khunt, Sandipan Prabhurao Bondge, Vikas Daulatrao Ahirao, Nitin Sharadchandra Pradhan
  • Patent number: 9006443
    Abstract: Disclosed herein is an improved, commercially viable and industrially advantageous process for the preparation of quinoline-3-carboxamide derivatives such as laquinimod, or a pharmaceutically acceptable salt thereof, in high yield and purity.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: April 14, 2015
    Assignee: Actavis Group PTC ehf
    Inventors: Girish Dixit, Krishnadatt Sharma, Kundan Singh Shekhawat, Nitin Sharadchandra Pradhan, Jon Valgeirsson
  • Patent number: 8981154
    Abstract: Provided herein are novel solid state forms of tapentadol salts, process for their preparation, pharmaceutical compositions, and method of treating thereof. The tapentadol salts include an L-(?)-camphorsulfonate salt, a dibenzoyl-(L)-tartrate salt, a dibenzoyl-(D)-tartrate salt, a malate salt, a maleate salt, or a salicylate salt.
    Type: Grant
    Filed: September 11, 2012
    Date of Patent: March 17, 2015
    Assignee: Actavis Group PTC EHF
    Inventors: Mayur Devjibhai Khunt, Sandipan Prabhurao Bondge, Nitin Sharadchandra Pradhan, Depashri Vikas Ahirao
  • Patent number: 8859769
    Abstract: Provided herein are improved, commercially viable and industrially advantageous processes for the preparation of a substantially pure ticagrelor intermediate, 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine, Formula (II). The intermediate is useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof in high yield and purity.
    Type: Grant
    Filed: February 15, 2011
    Date of Patent: October 14, 2014
    Assignee: Actavis Group PTC EHF
    Inventors: Anil Shahaji Khile, Jayesh Patel, Nikhil Trivedi, Nitin Sharadchandra Pradhan
  • Publication number: 20140206867
    Abstract: Disclosed herein is an improved process for the preparation of substituted cyclopentanamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Particularly described is an improved, commercially viable and industrially advantageous process for the preparation of a ticagrelor intermediate, [3aR-(3a?,4?,6?,6a?]-2-[[6-amino-2,2-dimethyltetrahydro-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-ethanol, alternatively named, 2-[[(3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]-dioxol-4-yl]oxy]-1-ethanol.
    Type: Application
    Filed: June 13, 2012
    Publication date: July 24, 2014
    Applicant: Actavis Group PTC EHF
    Inventors: Anil Shahaji Khile, Vignesh Nair, Nikhil Trivedi, Nitin Sharadchandra Pradhan
  • Publication number: 20140005401
    Abstract: Disclosed herein is an improved, commercially viable and industrially advantageous process for the preparation of quinoline-3-carboxamide derivatives such as laquinimod, or a pharmaceutically acceptable salt thereof, in high yield and purity.
    Type: Application
    Filed: September 9, 2013
    Publication date: January 2, 2014
    Applicant: ACTAVIS GROUP PTC EHF
    Inventors: Girish Dixit, Krishnadatt Sharma, Kundan Singh Shekhawat, Nitin Sharadchandra Pradhan, Jon Valgeirsson
  • Publication number: 20130317220
    Abstract: Provided herein is a novel process for the preparation of triazolo[4,5-d]pyrimidine derivatives. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of highly pure ticagrelor or a pharmaceutically acceptable salt thereof. Provided further herein is a novel process for the preparation of substituted cyclopentanamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of a ticagrelor intermediate, 2-[[(3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]-dioxol-4-yl]oxy]-1-ethanol.
    Type: Application
    Filed: December 16, 2011
    Publication date: November 28, 2013
    Applicant: Actavis Group Ptc Ehf
    Inventors: Vignesh Nair, Nikhil Trivedi, Anil Shahaji Khile, Nitin Sharadchandra Pradhan
  • Patent number: 8552194
    Abstract: Disclosed herein is an improved, commercially viable and industrially advantageous process for the preparation of quinoline-3-carboxamide derivatives such as laquinimod, or a pharmaceutically acceptable salt thereof, in high yield and purity.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: October 8, 2013
    Assignee: Actavis Group PTC EHF
    Inventors: Girish Dixit, Krishnadatt Sharma, Kundan Singh Shekhawat, Nitin Sharadchandra Pradhan, Jon Valgeirsson
  • Publication number: 20130165696
    Abstract: Provided herein are novel processes for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein are novel, commercially viable and industrially advantageous processes for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. Provided further herein are novel acid addition salts of trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine, and process for their preparation. The intermediate and its acid addition salts are useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity.
    Type: Application
    Filed: June 28, 2011
    Publication date: June 27, 2013
    Applicant: ACTAVIS GROUP PTC EHF
    Inventors: Anil Shahaji Khile, Vignesh Nair, Nikhil Trivedi, Nitin Sharadchandra Pradhan
  • Publication number: 20130150577
    Abstract: Provided herein is a novel process for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. The intermediate is useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity.
    Type: Application
    Filed: April 19, 2011
    Publication date: June 13, 2013
    Applicant: ACTAVIS GROUP PTC EHF
    Inventors: Anil Shahaji Khile, Jayesh Patel, Nikhil Trivedi, Nitin Sharadchandra Pradhan
  • Publication number: 20130101630
    Abstract: Provided herein is an impurity of varenicline, methylvarenicline, 6-methyl-5,8,14-triazatetracyclo[10.3.1.02,11,04,9]hexadeca-2(11),3,5,7,9-pentaene, and a process for the preparation and isolation thereof. Provided further herein is a highly pure varenicline or a pharmaceutically acceptable salt thereof substantially free of methylvarenicline impurity, processes for the preparation thereof, and pharmaceutical compositions comprising highly pure varenicline or a pharmaceutically acceptable salt thereof substantially free of methylvarenicline impurity.
    Type: Application
    Filed: March 8, 2011
    Publication date: April 25, 2013
    Applicant: ACTAVIS GROUP PTC EHF
    Inventors: Nitin Sharadchandra Pradhan, Arvapally Seshu Kumar, Nikhil Trivedi, Krishnadatt Sharma
  • Publication number: 20130096346
    Abstract: Provided herein is an improved and industrially advantageous optical resolution method for resolving (2R,3R)/(2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol, and use thereof for the preparation of tapentadol or a pharmaceutically acceptable salt thereof. Provided further herein is an improved and industrially advantageous optical resolution method for resolving (2R,3R)/(2S,3S)-[3-(3-methoxyphenyl)-2-methylpentyl]-dimethylamine, and use thereof for the preparation of tapentadol or a pharmaceutically acceptable salt thereof. Disclosed also herein is an improved, commercially viable and industrially advantageous process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof in high yield and purity.
    Type: Application
    Filed: March 1, 2011
    Publication date: April 18, 2013
    Applicant: ACTAVIS GROUP PTC EHF
    Inventors: Mayur Devjibhai Khunt, Sandipan Prabhurao Bondge, Nitin Sharadchandra Pradhan
  • Publication number: 20130096347
    Abstract: Provided herein is a novel, commercially viable and industrially advantageous process for the preparation of 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol (Tapentadol), or a pharmaceutically acceptable salt thereof, and its intermediates, in high yield and purity. Provided also herein are novel solid state forms of tapentadol intermediates and processes for their preparation thereof. Provided further herein is a purification process for preparing highly pure tapentadol hydrochloride.
    Type: Application
    Filed: April 4, 2011
    Publication date: April 18, 2013
    Applicant: ACTAVIS GROUP PTC EHF
    Inventors: Mayur Devjibhai Khunt, Sandipan Prabhurao Bondge, Nilesh Sudhir Patil, Haushabhau Shivaji Pagire, Nitin Sharadchandra Pradhan
  • Publication number: 20130090314
    Abstract: Provided herein are novel solid state forms of tapentadol salts, process for their preparation, pharmaceutical compositions, and method of treating thereof. The tapentadol salts include an L-(?)-camphorsulfonate salt, a dibenzoyl-(L)-tartrate salt, a dibenzoyl-(D)-tartrate salt, a malate salt, a maleate salt, or a salicylate salt.
    Type: Application
    Filed: September 11, 2012
    Publication date: April 11, 2013
    Applicant: ACTAVIS GROUP PTC EHF
    Inventors: Mayur Devjibhai Khunt, Sandipan Prabhurao Bondge, Nitin Sharadchandra Pradhan, Depashri Vikas Ahirao
  • Publication number: 20130072682
    Abstract: Provided herein is an improved, convenient, commercially viable and environmentally friendly process for the preparation of varenicline or a pharmaceutically acceptable salt thereof comprising reacting 1-(4 ,5-diamino-10-aza-tricyclo[6.3.1.02.7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone with chloroacetaldehyde in the presence of an oxygen source. Provided further herein is an improved and industrially advantageous process for the preparation of 1-(4,5-diamino-10-aza-tricyclo[6.3.1.02.7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone.
    Type: Application
    Filed: October 15, 2012
    Publication date: March 21, 2013
    Applicant: ACTAVIS GROUP PTC EHF
    Inventors: Actavis Group PTC EHF, Engelbert Seide
  • Publication number: 20130030176
    Abstract: Provided herein are improved, commercially viable and industrially advantageous processes for the preparation of a substantially pure ticagrelor intermediate, 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine, Formula (II). The intermediate is useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof in high yield and purity.
    Type: Application
    Filed: February 15, 2011
    Publication date: January 31, 2013
    Applicant: ACTAVIS GROUP PTC EHF
    Inventors: Anil Shahaji Khile, Jayesh Patel, Nikhil Trivedi, Nitin Sharadchandra Pradhan
  • Patent number: 8354428
    Abstract: Provided herein is a novel crystalline form of laquinimod, process for the preparation, pharmaceutical compositions, and method of treating thereof. Provided also herein are novel amorphous and polymorphic forms of laquinimod sodium, process for the preparation, pharmaceutical compositions, and method of treating thereof.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: January 15, 2013
    Assignee: Actavis Group PTC EHF
    Inventors: Girish Dixit, Krishnadatt Sharma, Nitin Sharadchandra Pradhan, Jon Valgeirsson
  • Patent number: 8314235
    Abstract: Provided herein is an improved, convenient, commercially viable and environmentally friendly process for the preparation of varenicline or a pharmaceutically acceptable salt thereof comprising reacting 1-(4,5-diamino-10-aza-tricyclo[6.3.1.02 7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone with chloroacetaldehyde in the presence of an oxygen source. Provided further herein is an improved and industrially advantageous process for the preparation of 1-(4,5-diamino-10-aza-tricyclo[6.3.1.02 7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone.
    Type: Grant
    Filed: August 31, 2009
    Date of Patent: November 20, 2012
    Assignee: Actavis Group PTC EHF
    Inventors: Girish Dixit, Krishnadatt Sharma, Kundan Singh Shekhawat, Nitin Sharadchandra Pradhan
  • Publication number: 20120269871
    Abstract: Provided herein are novel crystalline forms of rasagiline salts, processes for their preparation, pharmaceutical compositions, and method of treating thereof. The rasagiline salts include a maleate salt, a mandelate salt, or a salicylate salt.
    Type: Application
    Filed: December 29, 2010
    Publication date: October 25, 2012
    Applicant: ACTAVIS GROUP PTC EHF
    Inventors: Nilesh Sudhir Patil, Haushabhau Shivaji Pagire, Neela Praveen Kumar, Nitin Sharadchandra Pradhan