Abstract: The present invention relates to novel butyne diol derivatives of the general formula I and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of the general formula I and especially their use as endothelin receptor antagonists.
Type:
Grant
Filed:
June 24, 2002
Date of Patent:
April 13, 2004
Assignee:
Actelion Pharamceuticals Ltd.
Inventors:
Martin Bolli, Christoph Boss, Martine Clozel, Walter Fischli