Abstract: The present invention relates to S-enantiomerically enriched compositions of beta blockers and uses thereof, including uses of the beta blocker compositions for treating amyotrophic lateral sclerosis. The beta blocker compositions can also be used for preventing loss of lean mass, preventing body weight loss in subjects, improving quality of life in subjects, and prolonging survival in amyotrophic lateral sclerosis patients. The beta blocker can be oxprenolol or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
April 15, 2021
Date of Patent:
March 26, 2024
Assignee:
ACTIMED THERAPEUTICS LIMITED
Inventors:
Andrew J. S. Coats, Stefan Anker, Jochen Springer
Abstract: The present invention relates to compositions of S-enantiomer enriched oxprenolol and their use in treating cancer and treating or preventing, in cancer patients, cachexia, body weight loss, lean body mass loss and adipose tissue loss, and improving quality of life and prolonging survival of cancer patients.
Type:
Grant
Filed:
October 7, 2020
Date of Patent:
September 6, 2022
Assignee:
Actimed Therapeutics Limited
Inventors:
Andrew J. S. Coats, Stefan Anker, Jochen Springer
Abstract: The present invention relates to S-enantiomerically enriched compositions of beta blockers and uses thereof, including uses of the beta blocker compositions for treating amyotrophic lateral sclerosis. The beta blocker compositions can also be used for preventing loss of lean mass, preventing body weight loss in subjects, improving quality of life in subjects, and prolonging survival in amyotrophic lateral sclerosis patients. The beta blocker can be oxprenolol or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
October 18, 2019
Date of Patent:
May 18, 2021
Assignee:
ACTIMED THERAPEUTICS LIMITED
Inventors:
Andrew J. S. Coats, Stefan Anker, Jochen Springer
Abstract: The present invention relates to compositions of S-enantiomer enriched oxprenolol and their use in treating cancer and treating or preventing, in cancer patients, cachexia, body weight loss, lean body mass loss and adipose tissue loss, and improving quality of life and prolonging survival of cancer patients.
Type:
Grant
Filed:
March 16, 2018
Date of Patent:
November 10, 2020
Assignee:
Actimed Therapeutics Limited
Inventors:
Andrew J. S. Coats, Stefan Anker, Jochen Springer
Abstract: The present invention relates to compositions of S-enantiomer enriched oxprenolol and their use in treating cancer and treating or preventing, in cancer patients, cachexia, body weight loss, lean body mass loss and adipose tissue loss, and improving quality of life and prolonging survival of cancer patients.
Type:
Grant
Filed:
March 14, 2014
Date of Patent:
September 3, 2019
Assignee:
Actimed Therapeutics Limited
Inventors:
Andrew J.S. Coats, Stefan Anker, Jochen Springer