Abstract: The present invention relates to a process for the manufacture of titania-coated microspheres, preferably titania-coated inorganic microspheres, comprising at least the steps of: (i) providing a mixture comprising (a) a solution of a titania precursor of formula A pTi qF rin a solvent comprising water, wherein A is selected from the group consisting of hydrogen, alkali metal and ammonium, p is 2, 3, 4 or 6, q is 1 or 2 and r is 6, 7, 8 or 14 such that p+4q=r and (b) inorganic microspheres; (ii) adding a fluoride scavenger to the mixture; and (iii) maintaining the pH of the mixture in the range of 1 to less than 2 during at least a part of the process.

Abstract: A programmable injection device, comprising: a nozzle comprising a nozzle head with a fluid input hole and a distinct injection hole, the nozzle head accepts a dose of fluid from the fluid input hole to be injected into the skin of a patient through the injection hole, without use of a needle, a fluid capsule that is connected to said nozzle head and is adapted to provide the nozzle head with multiple doses of fluid for successive injections, without replacing the fluid capsule, an injection head that is adapted to have said fluid capsule and said nozzle head mounted onto it, comprising a first mechanism adapted to forcefully push a dose of a programmable amount of fluid from said fluid capsule to said nozzle head and a second mechanism for injecting by an programmable pressure said dose of fluid from said nozzle head into the skin of a patient in at least one of a programmable velocity or a programmable pressure applied to the skin surface.