Abstract: A substrate coated with a polymer obtained by grafting an aqueous monomer grafting solution comprising a mixture that includes sodium styrene sulphonate (NaSS) and methacrylic acid (MA) or acrylic acid (AA). The mixture has 10 to 90 mol % of sodium styrene sulphonate and 10 to 90 mol % of methacrylic acid or acrylic acid. The substrate is selected from among polyesters, vinyl polymers, polyacrylics and polymethacrylics, PEEK, silicones, natural polymers, natural or artificial celluloses, collagens, glycopolymers, ceramics, metals and metal alloys, and in particular Ti and alloys thereof and Ni—Ti alloys. The aqueous grafting solution has, in addition to the mixture which represents 90 to 99 mol % of the aqueous grafting solution, 1 to 10 mol % of hydroxyethylmethacrylate (HEMA).

Abstract: An oxidation and grafting method for grafting a bioactive polymer, such as polyNaSS, onto an article, in particular a polymer or ceramic article. The method comprises a step of oxidation by ozonation and a step of grafting by radical polymerisation in a polymerisation station having a first reactor. The two steps of oxidation and grafting are carried out consecutively in different solutions in the reactor of the polymerisation station.