Abstract: The present disclosure provides systems and methods for medical imaging. The system may comprise an optical adapter. The optical adapter may comprise a housing that comprises (1) a first end configured to releasably couple to a scope and (2) a second end configured to releasably couple to a camera. The optical adapter may comprise an image sensor coupled to the housing. The optical adapter may comprise an optics assembly disposed in the housing. The optics assembly may be configured to (1) receive light signals that are reflected from a target site within a subject's body and transmitted through the scope, and (2) reflect a first portion of the light signals onto the image sensor while permitting a second portion of the light signals to pass through to the camera.

Abstract: Provided herein are systems, methods, and media capable of determining estimated force applied on a target tissue region to enable tactile feedback during interaction with said target tissue region.

Abstract: Systems, methods, and computer program products for quantification of error in tool orientation of a surgical robotic are disclosed. A first robotic arm is provided where the robotic arm includes a surgical instrument and a tool disposed at the distal end of the surgical instrument. A first orientation of the tool is determined including a first x-component, a first y-component, and a first z-component. A desired orientation of the tool is determined including a second x-component, a second y-component, and a second z-component. A first angle between the first x-component and the second x-component is determined, a second angle between the first y-component and the second y-component is determined, and a third angle between the first z-component and the second z-component is determined. An error metric based on the first angle, the second angle, and the third angle is determined.

Abstract: A substrate coated with a polymer obtained by grafting an aqueous monomer grafting solution comprising a mixture that includes sodium styrene sulphonate (NaSS) and methacrylic acid (MA) or acrylic acid (AA). The mixture has 10 to 90 mol % of sodium styrene sulphonate and 10 to 90 mol % of methacrylic acid or acrylic acid. The substrate is selected from among polyesters, vinyl polymers, polyacrylics and polymethacrylics, PEEK, silicones, natural polymers, natural or artificial celluloses, collagens, glycopolymers, ceramics, metals and metal alloys, and in particular Ti and alloys thereof and Ni—Ti alloys. The aqueous grafting solution has, in addition to the mixture which represents 90 to 99 mol % of the aqueous grafting solution, 1 to 10 mol % of hydroxyethylmethacrylate (HEMA).

Abstract: The present disclosure provides systems and methods for discretizing a movement or a motion of one or more robotic arms. The system may comprise a robotic arm, an end effector coupled to a distal portion of the robotic arm, and a trocar through which the end effector may be inserted. The trocar may comprise a trocar reference point. The system may further comprise a processor configured to (i) determine a starting position and a destination position of a distal end of the end effector, (ii) determine a path between the starting position and the destination position, (iii) determine a plurality of points along the path, and (iv) determine a set of motions to move the distal end of the end effector from the starting position to the destination position, based at least in part on the trocar reference point.

Abstract: The present disclosure provides systems and methods for providing surgical guidance. In one aspect, the present disclosure provides a surgical guidance system comprising: an image processing module configured to (i) receive image data obtained using one or more image and/or video acquisition modules and (ii) generate one or more medical predictions or assessments based on (a) the image/video data or physiological data associated with the image/video data and (b) one or more training data sets comprising surgical or medical data associated with a patient or a surgical procedure. The one or more training data sets may comprise anatomical and physiological data obtained using a plurality of imaging modalities. The system may further comprise a visualization module configured to provide a surgical operator with an enhanced view of a surgical scene, based on the one or more augmented data sets.

Abstract: The present disclosure provides systems and methods for medical imaging. The system may comprise a scope assembly. The scope assembly may comprise a housing unit configured to releasably couple to at least a portion of an elongated scope. The scope assembly may comprise an imaging unit operably coupled to the housing unit, wherein the imaging unit comprises an optics assembly configured to (i) receive one or more light beams that are transmitted through the elongated scope and (ii) direct at least a portion of the one or more light beams onto two or more locations within a subject's body. At least one of the two or more locations may comprise a target site. The imaging unit may be configured to move via a rotational and/or translational motion relative to the housing unit to alter a field of view when imaging within the subject's body.

Abstract: A robotic suture knot tying system includes a first robotic arm, a second robotic arm, a suturing device including a suturing end effector operatively coupled to the first robotic arm, and a suture handling device operatively coupled to the second robotic arm. The system also includes a control system operatively coupled to the first robotic arm, the second robotic arm, the suturing device, and the suture handling device and configured to control operation thereof to cooperatively perform a suture knot tying procedure on a patient.

Abstract: Systems and methods for multi-modal sensing of three-dimensional position information of the surface of an object are disclosed. In particular, multiple visualization modalities are each used to collect distinctive positional information of a surface of an object. Each of the computed positional information is combined using weighting factors to compute a final, weighted three-dimensional position. In various embodiments, a first depth may be recorded using fiducial markers, a second depth may be recorded using a structured light pattern, and a third depth may be recorded using a light-field camera. Weighting factors may be applied to each of the recorded depths and a final, weighted depth may be computed.

Abstract: The present disclosure provides systems and methods for medical imaging. The system may comprise an optical adapter. The optical adapter may comprise a housing that comprises (1) a first end configured to releasably couple to a scope and (2) a second end configured to releasably couple to a camera. The optical adapter may comprise an image sensor coupled to the housing. The optical adapter may comprise an optics assembly disposed in the housing. The optics assembly may be configured to (1) receive light signals that are reflected from a target site within a subject's body and transmitted through the scope, and (2) reflect a first portion of the light signals onto the image sensor while permitting a second portion of the light signals to pass through to the camera.

Abstract: An oxidation and grafting method for grafting a bioactive polymer, such as polyNaSS, onto an article, in particular a polymer or ceramic article. The method comprises a step of oxidation by ozonation and a step of grafting by radical polymerisation in a polymerisation station having a first reactor. The two steps of oxidation and grafting are carried out consecutively in different solutions in the reactor of the polymerisation station.

Abstract: A plant extract obtained from saffron, with a safranal concentration, measured using the HPLC method, of a minimum of 0.2% by weight relative to the total dry matter weight. A method for obtaining the plant extract, as well as compositions comprising the plant extract, and methods of treatment.

Abstract: The present disclosure provides systems and methods for medical imaging. The system may comprise an optical adapter. The optical adapter may comprise a housing that comprises (1) a first end configured to releasably couple to a scope and (2) a second end configured to releasably couple to a camera. The optical adapter may comprise an image sensor coupled to the housing. The optical adapter may comprise an optics assembly disposed in the housing. The optics assembly may be configured to (1) receive light signals that are reflected from a target site within a subject's body and transmitted through the scope, and (2) reflect a first portion of the light signals onto the image sensor while permitting a second portion of the light signals to pass through to the camera.

Abstract: The invention concerns a nutritional or therapeutic agent comprising a molecule mix obtained from Vitis vinifera and Vaccinium angustifolium, comprising: at least 1% of catechins and epicatechins, the percentage being given by weight in relation to the total weight of the mix, preferably at least 5%, at least 5 ppm (parts per million in the mix) of ferulic acid, preferably at least 10 ppm. The invention also relates to the use of this agent due to its effects on cognitive functions in particular.

Abstract: The present disclosure provides systems and methods for processing laser speckle signals. The method may comprise obtaining a laser speckle signal from a laser speckle pattern generated using at least one laser light source that is directed towards a tissue region of a subject and a reference signal corresponding to a movement of a biological material of or within the subject's body. The method may comprise computing one or more measurements using a first function corresponding to at least the laser speckle signal and a second function corresponding to the reference signal. The method may comprise generating an output signal in part based on the one or more measurements for the function space and using the output signal to aid a surgical procedure on or near the tissue region of the subject.

Abstract: Systems and methods for multi-modal sensing of three-dimensional position information of the surface of an object are disclosed. In particular, multiple visualization modalities are each used to collect distinctive positional information of a surface of an object. Each of the computed positional information is combined using weighting factors to compute a final, weighted three-dimensional position. In various embodiments, a first depth may be recorded using fiducial markers, a second depth may be recorded using a structured light pattern, and a third depth may be recorded using a light-field camera. Weighting factors may be applied to each of the recorded depths and a final, weighted depth may be computed.

Abstract: The present disclosure provides systems and methods for medical imaging. The system may comprise an optical adapter. The optical adapter may comprise a housing that comprises (1) a first end configured to releasably couple to a scope and (2) a second end configured to releasably couple to a camera. The optical adapter may comprise an image sensor coupled to the housing. The optical adapter may comprise an optics assembly disposed in the housing. The optics assembly may be configured to (1) receive light signals that are reflected from a target site within a subject's body and transmitted through the scope, and (2) reflect a first portion of the light signals onto the image sensor while permitting a second portion of the light signals to pass through to the camera.

Abstract: The invention concerns a pet food or a pet supplement comprising a synergistically-effective antioxidant composition comprising an extract of Vitis vinifera and an extract of Vaccinium angustifolium, wherein said composition comprises at least 1% of catechins and/or epicatechins and at least 5 ppm of ferulic acid. The present invention further relates to the use of a synergistically-effective antioxidant composition as a medicament for pets, in particular in a method for treating a neurodegenerative disorder in a pet.

Abstract: The invention relates to a method and a device for generating a nanoaerosol, wherein at least one fluid to be atomized is atomized in a nozzle via a nozzle opening of the nozzle along a discharge direction in the form of fluid particles, the atomized fluid particles are deflected from the discharge direction and larger fluid particles are at least partially separated from smaller fluid particles, the separated larger fluid particles are returned to the fluid to be atomized and the smaller fluid particles are dispensed onto the environment. A cartridge in which the nozzle and the fluid to be atomized are arranged is used. According to the invention, a stream of a carrier gas is generated in the nozzle and at least one fluid to be atomized is brought into contact with the carrier gas.

Abstract: A sleeve material retaining loop is attached to or looped around a strap of a brassiere to retain gathered sleeve material or other items. One end of the sleeve material retaining loop extends out of the neck hole of the outer garment, and another end of the loop extends out of the arm hole of the sleeve above the shoulder of the wearer. The first and second ends of the sleeve material retaining loop are attached at the shoulder of the wearer to retain the sleeve. This helps prevent the sleeve from interfering with the wearer's movement and improves evaporative cooling of the wearer. A sleeve retaining loop storing mechanism stores the loop. Each sleeve retaining loop may be formed of separate interchangeable pieces that are attached to the brassiere. An additional piece of clothing may also be secured to a fastener on the brassiere.