Patents Assigned to ActivBiotics, Inc.
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Patent number: 7342011Abstract: The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3?-hydroxy analogs, 4?- and/or 6? halo and/or alkoxy analogs, and various 5? substituents that incorporate a cyclic amine moiety.Type: GrantFiled: August 11, 2004Date of Patent: March 11, 2008Assignee: ActivBiotics, Inc.Inventors: John H. van Duzer, Arthur F. Michaelis, William B. Geiss, Douglas G. Stafford, Joseph Raker
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Publication number: 20070238747Abstract: The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3?-hydroxy analogs, and/or various fused ring systems with the benzene ring at the 4?,5? or 5?,6? positions.Type: ApplicationFiled: May 17, 2007Publication date: October 11, 2007Applicant: ActivBiotics, Inc.Inventors: John van Duzer, Arthur Michaelis, William Geiss, Douglas Stafford, Xiang Yu, James Siedlecki, Yingfei Yang
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Patent number: 7271165Abstract: The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3?-hydroxy analogs, 4?- and/or 6? halo and/or alkoxy analogs, and various 5? substituents that incorporate a cyclic amine moiety.Type: GrantFiled: December 22, 2004Date of Patent: September 18, 2007Assignee: ActivBiotics, Inc.Inventors: John H. van Duzer, Arthur F. Michaelis, William B. Geiss, Douglas G. Stafford, Joseph Raker, Xiang Y. Yu, James M. Siedlecki, Yingfei Yang
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Publication number: 20070155715Abstract: The present invention features rifamycin analogs and methods of using these compounds to treat a variety of microbial infections.Type: ApplicationFiled: December 14, 2006Publication date: July 5, 2007Applicant: ActivBiotics, Inc.Inventors: John van Duzer, Arthur Michaelis, William Geiss, Douglas Stafford, Joseph Raker, Xiang Yu, James Siedlecki, Yingfei Yang
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Publication number: 20070142392Abstract: The invention features methods, compositions, and kits for treating prosthetic joint infections, foreign body infections, infectious arthritis, and osteomyelitisType: ApplicationFiled: December 14, 2006Publication date: June 21, 2007Applicant: ActivBiotics, Inc.Inventors: Christopher Murphy, David Rothstein
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Patent number: 7220738Abstract: The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3?-hydroxy analogs, and/or various fused ring systems with the benzene ring at the 4?,5? or 5?,6? positions.Type: GrantFiled: December 9, 2004Date of Patent: May 22, 2007Assignee: ActivBiotics, Inc.Inventors: John H. van Duzer, Arthur F. Michaelis, William B. Geiss, Douglas G. Stafford, Xiang Y. Yu, James M. Siedlecki, Yingfei Yang
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Publication number: 20070105849Abstract: The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3?-hydroxy analogs, 5?-halo and/or alkoxy analogs, and various 4?- and/or 6?-substituents that incorporate a cyclic amine moiety.Type: ApplicationFiled: November 2, 2006Publication date: May 10, 2007Applicant: ActivBiotics, Inc.Inventors: John Van Duzer, James Siedlecki, Xiang Yu
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Patent number: 7122525Abstract: The invention features a method of delivering a drug to a diseased cell by linking the drug to a rifamycin derivative, compositions that include drug-rifamycin conjugates of the invention, and methods for treating disease using those compositions.Type: GrantFiled: November 21, 2002Date of Patent: October 17, 2006Assignee: ActivBiotics, Inc.Inventors: Arthur F. Michaelis, Hawkins V. Maulding, Chalom Sayada, Congxiang Zha
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Patent number: 7078399Abstract: The invention features sulfhydryl rifamycin compositions, methods of making these compositions, and methods for treating disease using these compositions.Type: GrantFiled: December 12, 2002Date of Patent: July 18, 2006Assignee: ActivBiotics, Inc.Inventors: Arthur F. Michaelis, Hawkins V. Maulding, Chalom Sayada, Barry Eisenstein, William B. Geiss, Joseph Raker
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Publication number: 20050282242Abstract: The present invention provides methods for screening antimicrobial agents that make use of mutated microbial polypeptides. Because these polypeptides have biological activity and result in increased antimicrobial drug resistance, candidate compounds that specifically target these polypeptides provide therapeutics or therapeutic lead compounds for treating infections caused by drug resistant microbial pathogens.Type: ApplicationFiled: April 27, 2005Publication date: December 22, 2005Applicant: ActivBiotics, Inc.Inventors: David Rothstein, Christopher Murphy, Ian MacNeil
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Publication number: 20050143374Abstract: The invention features compounds that act as antimicrobial agents and/or antimicrobial enhancer agents, compositions that include the antimicrobial enhancer agents of the invention, and methods for treating microbial infections using those compositions.Type: ApplicationFiled: February 24, 2005Publication date: June 30, 2005Applicant: ActivBiotics, Inc.Inventors: Arthur Michaelis, Hawkins Maulding
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Patent number: 6900204Abstract: The invention features compounds that act as antimicrobial agents and/or antimicrobial enhancer agents, compositions that include the antimicrobial enhancer agents of the invention, and methods for treating microbial infections using those compositions.Type: GrantFiled: September 6, 2002Date of Patent: May 31, 2005Assignee: ActivBiotics, Inc.Inventors: Arthur F. Michaelis, Hawkins V. Maulding