Patents Assigned to Acuitas Therapeutics Inc.
  • Carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids
    Patent number: 11820728
    Abstract: Compounds are provided having one of the following structures (I) or (II): or (I) (II) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3a, R3b, L1, L2, G1a, G1b, G2a, G2b and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: November 21, 2023
    Assignee: Acuitas Therapeutics, Inc.
    Inventors: Xinyao Du, Steven M. Ansell
  • Lipid nanoparticle formulations
    Patent number: 11712481
    Abstract: Improved formulations of lipid nanoparticles are provided. Use of the lipid nanoparticles for delivery of a therapeutic agent and methods for their preparation are also provided.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: August 1, 2023
    Assignee: Acuitas Therapeutics, Inc.
    Inventors: Michael J. Hope, Barbara Mui, Paulo Jia Ching Lin, Christopher J. Barbosa, Thomas D. Madden, Steven M. Ansell, Xinyao Du
  • Lipids and lipid nanoparticle formulations for delivery of nucleic acids
    Patent number: 11648324
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: May 11, 2021
    Date of Patent: May 16, 2023
    Assignee: Acuitas Therapeutics, Inc.
    Inventors: Steven M. Ansell, Xinyao Du
  • Lipids for use in lipid nanoparticle formulations
    Patent number: 11639329
    Abstract: Compounds are provided having the following structure: [Formula should be inserted here] or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: May 2, 2023
    Assignee: Acuitas Therapeutics, Inc.
    Inventor: Xinyao Du
  • Lipids and lipid nanoparticle formulations for delivery of nucleic acids
    Patent number: 11634379
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, a, b, c, d and e are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: April 25, 2023
    Assignee: Acuitas Therapeutics, Inc.
    Inventors: Steven M. Ansell, Xinyao Du
  • Lipids for use in lipid nanoparticle formulations
    Patent number: 11542225
    Abstract: Compounds are provided having the following structure (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein G1, G1?, G2, G2?, G3, L1, L1?, L2, L2?, X, X?, Y and Y? are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: January 3, 2023
    Assignee: Acuitas Therapeutics, Inc.
    Inventor: Xinyao Du
  • Lipids for use in lipid nanoparticle formulations
    Patent number: 11524932
    Abstract: Compounds are provided having the following structure (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein X, Y, L1, L2, L3, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: December 13, 2022
    Assignee: Acuitas Therapeutics, Inc.
    Inventor: Xinyao Du
  • Lipids for lipid nanoparticle delivery of active agents
    Patent number: 11453639
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein R1, R2, R3, R4, R5, L1, L2, L3, G1, G2, and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: September 27, 2022
    Assignee: ACUITAS THERAPEUTICS, INC.
    Inventor: Xinyao Du
  • Lipids for delivery of active agents
    Patent number: 11357856
    Abstract: Compounds are provided having the following structure: Formula (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R, R1, R2, G1, G2 and n are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: June 14, 2022
    Assignee: ACUITAS THERAPEUTICS, INC.
    Inventors: Steven M. Ansell, Xinyao Du
  • Lipids and lipid nanoparticle formulations for delivery of nucleic acids
    Patent number: 11168051
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, G1, G2, G3, a, b, c and d are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: November 9, 2021
    Assignee: ACUITAS THERAPEUTICS, INC.
    Inventors: Xinyao Du, Steven M. Ansell
  • LIPID NANOPARTICLE MRNA VACCINES
    Publication number: 20210251898
    Abstract: The invention relates to mRNA comprising lipid nanoparticles and their medical uses. The lipid nanoparticles of the present invention comprise a cationic lipid according to formula (I), (II) or (III) and/or a PEG lipid according to formula (IV), as well as an mRNA compound comprising an mRNA sequence encoding an antigenic peptide or protein. The invention further relates to the use of said lipid nanoparticles as vaccines or medicaments, in particular with respect to influenza or rabies vaccination.
    Type: Application
    Filed: January 6, 2021
    Publication date: August 19, 2021
    Applicants: CureVac AG, Acuitas Therapeutics Inc.
    Inventors: Patrick BAUMHOF, Mariola FOTIN-MLECZEK, Regina HEIDENREICH, Michael J. HOPE, Edith JASNY, Sandra LAZZARO, Paulo Jia Ching LIN, Johannes LUTZ, Barbara MUI, Benjamin PETSCH, Susanne RAUCH, Kim Ellen SCHMIDT, Ying TAM
  • Lipids and lipid nanoparticle formulations for delivery of nucleic acids
    Patent number: 11040112
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: June 22, 2021
    Assignee: ACUITAS THERAPEUTICS, INC.
    Inventors: Steven M. Ansell, Xinyao Du
  • Lipids and lipid nanoparticle formulations for delivery of nucleic acids
    Patent number: 10723692
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, a, b, c, d and e are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: July 28, 2020
    Assignee: Acuitas Therapeutics, Inc.
    Inventors: Steven M. Ansell, Xinyao Du
  • Lipids and lipid nanoparticle formulations for delivery of nucleic acids
    Patent number: 10221127
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, G1, G2, G3, a, b, c and d are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: March 5, 2019
    Assignee: Acuitas Therapeutics, Inc.
    Inventors: Xinyao Du, Steven M. Ansell
  • LIPIDS AND LIPID NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS
    Publication number: 20190022247
    Abstract: Compounds are provided having the following structure (I) or (II): or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R, R1, R2, L, X, L, G1, G2, Z, a1, a2 and n are independently as defined herein for each of structures (I) and (II). Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Application
    Filed: December 30, 2016
    Publication date: January 24, 2019
    Applicant: Acuitas Therapeutics, Inc.
    Inventors: Steven M. Ansell, Xinyao Du
  • Lipids and lipid nanoparticle formulations for delivery of nucleic acids
    Patent number: 10166298
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: January 1, 2019
    Assignee: Acuitas Therapeutics, Inc.
    Inventors: Steven M. Ansell, Xinyao Du
  • Lipids and lipid nanoparticle formulations for delivery of nucleic acids
    Patent number: 10106490
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, a, b, c, d and e are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: October 23, 2018
    Assignee: Acuitas Therapeutics, Inc.
    Inventor: Xinyao Du
  • Lipids and lipid nanoparticle formulations for delivery of nucleic acids
    Patent number: 9737619
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, a, b, c, d and e are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: August 22, 2017
    Assignee: Acuitas Therapeutics, Inc.
    Inventors: Steven M. Ansell, Xinyao Du
  • Lipids and lipid nanoparticle formulations for delivery of nucleic acids
    Patent number: 9738593
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, a, b, c, d and e are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: August 22, 2017
    Assignee: Acuitas Therapeutics Inc.
    Inventors: Steven M. Ansell, Xinyao Du
  • METHODS AND COMPOSITIONS FOR DELIVERY OF NUCLEIC ACIDS
    Publication number: 20160317676
    Abstract: A lipid particle can include a plurality of cationic lipids, such as a first cationic lipid and a second cationic lipid. The first cationic lipid can be selected on the basis of a first property and the second cationic can be selected on the basis of a second property. The first and second properties are complementary. The attributes of the lipid particle can reflect the selected properties of the cationic lipids, and the complementary nature of those properties.
    Type: Application
    Filed: May 11, 2016
    Publication date: November 3, 2016
    Applicants: Tekmira Pharmaceuticals Corporation, The University of British Columbia, Acuitas Therapeutics Inc.
    Inventors: Michael J. Hope, Thomas D. Madden, Pieter R. Cullis, Martin Maier, Muthusamy Jayaraman, Kallanthottathil G. Rajeev, Akin Akinc, Muthiah Manoharan, Ismail Hafez