Abstract: Provided herein are implantable compositions and methods of use thereof for the local delivery of therapeutically active agents.

Abstract: Embodiments include a surgical implant delivery system for positioning and affixing a surgical implant (e.g., a surgical mesh, a surgical buttress, etc.) covering a surgical margin. The system includes a cartridge releasably holding the surgical implant and a plurality of fixation elements associated with the surgical implant. The system also includes a introducer having an elongate body, a head pivotably coupled to receive the cartridge forming a combined head and cartridge, and a handle including a grip and an in-line trigger. The introducer also includes an actuation mechanism connected with the in-line trigger of the handle configured to affix the surgical implant to the surgical margin using the one or more fixation elements.