Abstract: A three-dimensional, biocompatible scaffold precursor composition for room-temperature printing a bio-compatible polymer/hydroxyapatite composite scaffold includes a room-temperature slurry, comprising a mixture of a sold phase that includes a mixture of tetracalcium phosphate (TTCP; Ca4(PO4)2O) and dicalcium phosphate anhydrous (DCPA; CaHPO4), and a liquid phase that includes a polymer in a solvent. The solvent may be Ethanol (EtOH) or Tetrahydrofuran (THF), and the polymer may be polyvinyl butyral (PVB), polycaprolactone (PCL), or poly lactic-co-glycolic acid (PLGA). The slurry is printed at room temperature in aqueous phosphate (NaH2PO4) bath, which works as hardening accelerator, forming the polymer/hydroxyapatite composite scaffold.
Type:
Grant
Filed:
June 5, 2020
Date of Patent:
June 27, 2023
Assignee:
ADA Science and Research Institute LLC
Inventors:
Stella Alimperti, Yoontae Kim, Eun-Jin Lee, Laurence C Chow, Shozo Takagi
Abstract: A three-dimensional, biocompatible scaffold precursor composition for room-temperature printing a bio-compatible polymer/hydroxyapatite composite scaffold includes a room-temperature slurry, comprising a mixture of a sold phase that includes a mixture of tetracalcium phosphate (TTCP; Ca4(PO4)2O) and dicalcium phosphate anhydrous (DCPA; CaHPO4), and a liquid phase that includes a polymer in a solvent. The solvent may be Ethanol (EtOH) or Tetrahydrofuran (THF), and the polymer may be polyvinyl butyral (PVB), polycaprolactone (PCL), or poly lactic-co-glycolic acid (PLGA).
Type:
Application
Filed:
June 5, 2020
Publication date:
August 26, 2021
Applicant:
ADA Science and Research Institute LLC
Inventors:
Stella Alimperti, Yoontae Kim, Eun-Jin Lee, Laurence C. Chow, Shozo Takagi