Abstract: A nuclear camera system includes a pair of detectors orientated 180 degrees apart about an axis of rotation for detecting radiation emitted from an object, a pair of single-photon radiation point sources for transmitting radiation through the object, each to a different detector, and a gantry supporting the detectors and the radiation sources. The gantry provides rotation of the detectors and the radiation source about the axis of rotation, such that the angular positions of the radiation source about the axis of rotation remain fixed relative to the angular positions of the detectors. The camera system further includes a processing system coupled to control the dectors and the radiation sources and to selectably configure the detectors for either coincidence or single-photon emission imaging.

Abstract: A method of correcting coincidence data for random coincidences in a nuclear medicine imaging system is provided. The system includes a pair of detectors that are rotatable about an axis, with an object to be imaged disposed about the axis. During an imaging session, the detectors detect coincidence radiation emitted from the object at a plurality of angular stops relative to the axis. While rotating the detectors between stops, the detectors are reconfigured for single-photon data acquisition and are used to detect radiation in singles mode. The detected singles are rebinned into a plurality of randoms sinograms, which are used to correct the coincidence data.

Abstract: A system for acquisition, processing and display of gated SPECT imaging data for use in diagnosing Coronary Artery Disease (CAD) in nuclear medicine. The present invention provides a physician with two parameters for evaluating CAD: information relating to the distribution of blood flow within the myocardium (perfusion) and information relating to myocardium wall motion (function). One aspect of the present invention provides the physician with a display of functional images representing quantitative information relating to both perfusion and function with respect to selected regions of interest of the subject heart at end-diastole and end-systole segments of the cardiac cycle. The functional display consists of arcs of varied width depending on wall motion and color coded to illustrate degrees of myocardial perfusion for different pie shaped sections of a selected region of interest within a given short axis slice of reconstructed volume data.

Abstract: A scintillation camera detector head comprises a scintillation crystal, a plurality of photomultiplier tubes (PMTs) optically coupled to the scintillation crystal, and a diffractive surface, such as a holographic optical element (HOE), optically coupled to the scintillation crystal. The diffractive surface preferentially reflects or redirects light from a scintillation event which impinges upon the surface toward one or more predetermined PMTs as a function of the angle of incidence or the location of the event. Light emitted under a peak PMT can be preferentially reflected or transmitted away from the peak PMT and toward the surrounding PMTs to reduce spatial resolution modulation. Alternatively, light impinging on the surface from an event can be directed toward the peak PMT and away from surrounding PMTs to achieve greater isolation of events.

Abstract: A dual-head gamma camera imaging system comprises a master ring gear and a slave ring rotatable about a longitudinal axis. The master ring gear is rotatably supported by a gantry. The slave ring is rotatably supported by the master ring gear and concentric with the master ring gear, such that the master ring gear and the slave ring can be rotated independently about s longitudinal axis. A first detector is supported by a first cantilever support member mounted to the master ring gear. A second detector head is supported by a second cantilever support member mounted to the slave ring. The angular displacement between the detector heads can be varied by providing relative rotation between the master ring gear and the slave ring. The rotation can be accomplished by using the weight of one of the detector heads to hold that detector head stationary while rotating the other detector head using a motor.

Abstract: The present invention provides an apparatus and method for enhancing the resolution of a Positron Emission Tomography (PET) image in a Nuclear Camera System that is configurable to performs both PET and SPECT imaging. The apparatus includes a crystal that interacts with a gamma ray to create a scintillation event within the surface of the crystal. The gamma rays that impinge the crystal have an incident angle that is limited by a field of view of the crystal. Positioned behind the crystal is a detector that responds to the light photons released by the scintillation event and registers a coordinate value of the scintillation event. Coupled to the detector is a resolution enhancer that generates an in-crystal plane displacement correction value for the coordinate value registered by the detector. The in-crystal plane displacement correction value is then combined with the coordinate value to compute the actual entry point of the gamma ray into the crystal.

Abstract: A method of reconstructing an image in a medical imaging system comprises the steps of detecting transverse rays and oblique rays using a limited range of projection angles. The limited range of projection angles is achieved by either limiting the range of rotation of the detectors at each position along the z axis, or by causing the detectors to trace a continuous-motion helical path along the z axis. Data is then rebinned to create a stack of partially-complete sinograms corresponding to individual transverse slice images corresponding to, in the aggregate, a three-dimensional image. Because of the limited projection angles, each sinogram represents an incomplete data set. The rebinning includes, for each oblique ray, identifying among the sinograms the images intersected by the ray, and, applying to each of the sinograms associated with the images intersected by the ray an increment that is representative of the ray.

Abstract: A method of performing image reconstruction in a gamma camera system comprises the steps of performing a transmission scan of an object about a number of rotation angles to collect transmission projection data and performing an emission scan of the object about numerous rotation angles to collect emission projection data. The outer boundary of the object is then located based on the transmission projection data. Information identifying the boundary is then either stored in a separate body contour map or embedded in an attenuation map. The information identifying the boundary can be in the form of flags indicating whether individual pixels are inside or outside the boundary of the object. The emission projection data is then reconstructed, using the attenuation map if desired, to generate transverse slice images.

Abstract: A system for acquisition, processing and display of gated SPECT imaging data for use in diagnosing Coronary Artery Disease (CAD) in nuclear medicine. The present invention provides a physician with two parameters for evaluating CAD: information relating to the distribution of blood flow within the myocardium (perfusion) and information relating to myocardium wall motion (function). One aspect of the present invention provides the physician with a display of functional images representing quantitative information relating to both perfusion and function with respect to selected regions of interest of the subject heart at end-diastole and end-systole segments of the cardiac cycle. The functional display consists of arcs of varied width depending on wall motion and color coded to illustrate degrees of myocardial perfusion for different pie shaped sections of a selected region of interest within a given short axis slice of reconstructed volume data.

Abstract: A method of calibrating an attenuation map for use in emission imaging in a gamma camera system. The attenuation map is generated using a transmission scan of the object of interest. The map includes a number of attenuation coefficients for the object. A computer program for generating the attenuation map includes an instruction for scaling the attenuation coefficients in the map from the transmission energy level to the emission energy level using a scaling factor. The scaling factor includes an effective attenuation coefficient for water, which is determined empirically. To determine the effective attenuation coefficient, the number of photons which pass from a transmission source through known depths of water using the emission energy level is counted. The effective attenuation coefficient is computed based on a standard equation describing the attenuation of photons by an absorber. The scaling factor used by the computer program is then set based on the effective attenuation coefficient.

Abstract: A method of coregistering medical image data of different modalities is provided. In the method, an emission scan of an object is performed using a nuclear medicine imaging system to acquire single-photon emission computed tomography (SPECT) image data. A transmission scan of the object is performed simultaneously with the emission scan using the same nuclear medicine imaging system in order to acquire nuclear medicine transmission image data. The emission scan is performed using a roving zoom window, while the transmission scan is performed using the full field of view of the detectors. By knowing the position of the zoom windows for each detection angle, the nuclear medicine transmission image data can be coregistered with the SPECT emission image data as a result of the simultaneous scans.

Abstract: A correction system for correcting and maintaining the baseline offset signal value of a PMT channel of a scintillation detector at a predetermined value. The correction system utilizes an event driven mode wherein the correction is performed based on detected gamma interactions and this mode is utilized during periods of high count rate. Using the event driven correction mode, the system provides an output of far PMT channels based on a detected peak PMT channel. In a second mode, software driven correction, false triggers are inserted into the processing logic to initiate sampling of the baseline offset signal value and "simulate" gamma interactions. The false triggers are used by the system to perform baseline correction. The second mode is used during periods of lower count rate. Under both modes, the system effectively samples the baseline offset values from a channel that detects substantially no light energy to sample the baseline offset amount.

Abstract: A scan speed procedure and method wherein a minimum radiation exposure period is determined on an object by object basis for a transmission study. Two transmission scans are performed including a prescan followed by a second transmission scan phase. The first transmission prescan is performed using a radiation source over the object. This prescan is of a rapid and predetermined duration (Tp). A resultant count density associated with the object is then generated and examined. The portion having the smallest count density (Cm) is determined and a value (Co) representing the minimum required number of counts for transmission study is given. From the above, a transmission period (Ts) is determined by the system and the second transmission scan phase is performed for the duration Ts using a multi-pass scan phase.

Abstract: A dual head nuclear camera system automatically switchable (and optimized) to perform either SPECT imaging or PET imaging that utilizes attenuation correction for nonuniform attenuation in SPECT or PET modes. The dual head detectors contain switchable triggering circuitry so that coincidence detection for PET imaging and non-coincidence detection for SPECT imaging is available. The system uses a variable integration technique with programmable integration interval; variable sized clusters for centroiding, use of dual integrators per PMT channel, the event detection and acquisition circuitry of the camera system is switchable for PET and SPECT imaging. In such a switchable SPECT/Pet dual head camera system, a mechanism and method is shown to perform transmission and emission scanning sessions with two line sources and two detectors wherein two sliding transmission detection windows are employed to differentiate between transmission and emission photons.

Abstract: A gamma camera for a Positron Emission Tomography (PET) system comprises a single, continvous scintillation crystal having an imaging surface, and a first layer of septa disposed along the imaging surface between the object and the imaging surface. A gap is provided between the imaging surface and the first layer of septa to allow non stray radiation to reach the imaging surface. The septa may be arranged to have a long axis disposed at an acute angle away from perpendicular to an axis of rotation or made to move in relation to the imaging surface of the scintillation crystal to reduce cold spots on the image. Multiple layers of septa may be provided.

Abstract: A method and apparatus for collecting transmission information utilizing a large field of view of a detector and for collecting emission data using a small field of view window of the same detector. The system employs the large field of view of a scintillation detector in order to collect transmission data for the entire body being scanned. Such a technique improves the quantitative capability of emission data by acquiring non-truncated attenuation factors. The emission data of a small field of view window is collected so that high resolution image pixels are used for processing the emission data (e.g., of a particular body organ). Since a large field of view is used for collecting the transmission data, the imaging pixels for transmission data are of lower resolution than the emission data. The emission data can be collected using a roving zoom technique during an ECT scan.

Abstract: A mechanism and method for performing transmission and emission scanning sessions with two line sources and two detectors wherein two sliding transmission detection windows are employed to differentiate between transmission and emission photons. Transmission and emission data can be collected simultaneously. This system provides that the dual transmission detection windows are each associated with a particular line source and move in synchronization with the associated line source. Further, the two line sources and the two detector windows all move in synchronization in the direction of the long axis of the object being scanned and at any given position all are within a given spatial plane that is transverse to the long axis of the object. In this configuration, the system can effectively reduce the amount of cross-talk detected by a detector (e.g., cross-talk being scattered photon radiation detected by a given detector but not originating from the detector's associated line source).

Abstract: A multi-detector head nuclear camera system automatically switchable (and optimized) to perform either SPECT imaging or PET imaging. The camera system employs, in one embodiment, multi-detector configuration having dual head scintillation detectors but can be implemented with more than two detector heads. The detectors contain switchable triggering circuitry so that coincidence detection for PET imaging and non-coincidence detection for SPECT imaging is available. Using a variable integration technique with programmable integration interval, the event detection and acquisition circuitry of the camera system is switchable to detect events of different energy distribution and count rate which are optimized for PET and SPECT imaging. The system also includes dual integrators on each scintillation detector channel for collecting more than one event per detector at a time for PET or SPECT mode.

Abstract: A variable filter arrangement wherein differently sized and shaped filters are automatically selected and installed from a collection of filters housed within a configuration for use with a radiation source. The line source is typically used for transmission scanning to collect attenuation correction factors. A line source is utilized in the preferred embodiment and a series of filters (e.g., differently sized "bow-tie" filters) are rotatably attached to a central junction so that a particular filter can be rotated into an installed position. When installed, the filter acts to attenuate the radiation emitted from the line source to reduce radiation emitted on an otherwise unobstructed area of a scintillation detector. Differently sized filters are advantageously used to accommodate differently sized patents and also to accommodate different unobstructed parts of a detector for different angles of rotation during an ECT transmission scan.

Abstract: A circuit for performing digital dynamic compression wherein the circuit is readily modifiable to accept different compression procedures and the input and output signals are in digital form. The system utilizes a memory unit (e.g., a random access memory or other form of programmable memory, such as EEPROM) to contain a procedure utilized to transform digital input channel signal to an offset digital value which is determined based on the total energy of a gamma interaction. This offset digital value is then subtracted from the digital input channel data to arrive at the output dynamically compressed value. However, given sufficient memory size, the memory circuit may be implemented to directly output the compressed value. Since a programmable memory look up table is utilized to contain the dynamic compression procedure, different dynamic compression procedures may be readily loaded into the memory from a computer system.