Abstract: Compositions having enhanced gas and drug transporting capability, are prepared by providing a perfluoro compound dispersed in an aqueous medium with a surfactant to form an aqueous initial dispersion, concentrating the perfluoro compound phase of the dispersion as by centrifugation or filtration, wherein a portion of the surfactant remains complexed with the particles of the perfluoro compound phase and the balance of the surfactant is in the aqueous phase, separating the phases, and redispersing the particles of the concentrated perfluoro compound phase to form a final dispersion in which greater than 65% by weight, and preferably at least 75%, of the surfactant present is complexed with the perfluoro compound particles.
Abstract: Method of sensitizing hypoxic tumor cells to radiotherapy and chemotherapy by contacting the cells or the vasculature thereof with an aqueous dispersion of an oxygen carrying perfluoro compound and a dispersant for the compound, and sensitizing chemotherapeutic and protective compositions therefor.
Type:
Grant
Filed:
January 11, 1988
Date of Patent:
December 26, 1989
Assignee:
Adamantech, Inc.
Inventors:
John M. Yuhas, Robert L. Goodman, Robert E. Moore
Abstract: An inert, water-immiscible inert organic liquid having gas transport properties, water and a suitable emulsifying agent are formed into a stable gel by emulsifying a mixture of the same, concentrating the emulsion to form a gel phase and a liquid phase and separating the two phases. The resulting gel can be used as an ointment or cosmetic for skin irritations or wounds, or as a coating in industrial applications where extended contact of a surface with a gas, such as oxygen, is desired. Fluorocarbons or low viscosity silicone oils are suitable organic liquid components of the gels.
Abstract: Fluorocarbons are purified and toxicity substantially reduced by contact with a substantially dry, strongly basic and strongly nucleophilic alkali or alkaline earth metal compound, and separating the decomposition products which form.
Abstract: Method of sensitizing hypoxic tumor cells to radiotherapy and chemotherapy by contacting the cells or the vasculature thereof with an aqueous dispersion of an oxygen carrying perfluoro compound and a dispersant for the compound, and sensitizing chemotherapeutic and protective compositions therefor.
Type:
Grant
Filed:
September 9, 1987
Date of Patent:
May 3, 1988
Assignee:
Adamantech, Inc.
Inventors:
John M. Yuhas, deceased, Robert L. Goodman, Robert E. Moore
Abstract: Method of X-raying animals using as a contrast agent a perfluorobromoalkyl ether of the formula C.sub.m F.sub.2m+1 OC.sub.n F.sub.2n Br where m and n independently are integers of from 2 to 6, wherein the ether is used either neat or in an aqueous dispersion such as an emulsion.
Type:
Grant
Filed:
March 11, 1985
Date of Patent:
February 3, 1987
Assignees:
Adamantech, Inc., Children's Hospital Research Foundation
Abstract: An inert, water-immiscible inert organic liquid having gas transport properties, water and a suitable emulsifying agent are formed into a stable gel by emulsifying a mixture of the same, concentrating the emulsion to form a gel phase and a liquid phase, and separating the two phases. The resulting gel can be used as an ointment or cosmetic for skin irritations or wounds, or as a coating in industrial applications where extended contact of a surface with a gas, such as oxygen, is desired. Fluorocarbons or low viscosity silicone oils are suitable organic liquid components of the gels.