Patents Assigned to Adaptimmune Limited
  • High affinity NY-ESO T cell receptors
    Patent number: 9156903
    Abstract: The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC SEQ ID NO:126 peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumor cells. The TCRs have a KD for the said peptide-HLA complex of less than or equal to 1 ?M and/or have an off-rate (koff) of 1×10?3 S?1 or slower.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: October 13, 2015
    Assignee: ADAPTIMMUNE LIMITED
    Inventors: Jonathan Michael Boulter, Bent Karsten Jakobsen, Yi Li, Peter Eamon Molloy, Steven Mark Dunn
  • Cells expressing modified T cell receptor
    Patent number: 9115372
    Abstract: This invention provides a cell presenting at least one T cell receptor (TCR) anchored to the membrane by a transmembrane sequence, said TCR comprising an interchain disulfide bond between extracellular constant domain residues which is not present in native TCRs.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: August 25, 2015
    Assignees: IMMUNOCORE LIMITED, ADAPTIMMUNE LIMITED
    Inventor: Bent Karsten Jakobsen
  • T CELL RECEPTOR DISPLAY
    Publication number: 20140371085
    Abstract: A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identification of high affinity TCRs. Several high affinities are disclosed.
    Type: Application
    Filed: April 9, 2014
    Publication date: December 18, 2014
    Applicants: ADAPTIMMUNE LIMITED, IMMUNOCORE LIMITED
    Inventors: Bent Karsten Jakobsen, Torben Bent Andersen, Peter Eamon Molloy, Yi Li
  • T CELL RECEPTOR DISPLAY
    Publication number: 20140349855
    Abstract: A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identification of high affinity TCRs. Several high affinities are disclosed.
    Type: Application
    Filed: April 10, 2014
    Publication date: November 27, 2014
    Applicants: ADAPTIMMUNE LIMITED, IMMUNOCORE LIMITED
    Inventors: Bent Karsten Jakobsen, Torben Bent Andersen, Peter Eamon Molloy, Yi Li
  • T cell receptor display
    Patent number: 8741814
    Abstract: A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identification of high affinity TCRs. Several high affinities are disclosed.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: June 3, 2014
    Assignees: Immunocore Limited, Adaptimmune Limited
    Inventors: Bent Karsten Jakobsen, Torben Bent Andersen, Peter Eamon Molloy, Yi Li, Jonathan Michael Boulter