Patents Assigned to Adaptive Biotechnolgies Corp.
  • Rare clonotypes and uses thereof
    Patent number: 9528160
    Abstract: The invention is directed to a method of selecting disease-correlated clonotypes that have a reduced likelihood of producing a false positive signal of relapse when, used to monitor minimal residual disease. In accordance with the invention, candidate correlating clonotype are obtained from a patient, the rarity of each is determined either by comparison with a clonotype database or a clonotype model, and one or more of the rarest of such clonotypes are used to monitor the minimal residual disease.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: December 27, 2016
    Assignee: Adaptive Biotechnolgies Corp.
    Inventors: Francois Pepin, Malek Faham, Martin Moorhead