Patents Assigned to ADASTRA PHARMACEUTICALS, INC.
  • Use of TG02 for treating gliomas in pediatric subjects
    Patent number: 11173160
    Abstract: The present disclosure relates to uses of TG02, for treating a glioma in a pediatric human subject. In certain embodiments, the glioma can be a pediatric high-grade glioma (PHGG), e.g., a diffuse intrinsic pontine glioma (DIPG), and/or a H3.3-mutated glioma (e.g., a H3K27M-mutated glioma). The present disclosure further provides pharmaceutical compositions and kits that include an ERK5 inhibitor.
    Type: Grant
    Filed: August 12, 2020
    Date of Patent: November 16, 2021
    Assignees: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, ADASTRA PHARMACEUTICALS, INC.
    Inventors: Sameer Agnihotri, Alberto Broniscer, Ian F. Pollack, Thomas M. Estok
  • USE OF TG02 FOR TREATING GLIOMAS IN PEDIATRIC SUBJECTS
    Publication number: 20200368242
    Abstract: The present disclosure relates to uses of TG02, for treating a glioma in a pediatric human subject. In certain embodiments, the glioma can be a pediatric high-grade glioma (PHGG), e.g., a diffuse intrinsic pontine glioma (DIPG), and/or a H3.3-mutated glioma (e.g., a H3K27M-mutated glioma). The present disclosure further provides pharmaceutical compositions and kits that include an ERK5 inhibitor.
    Type: Application
    Filed: August 12, 2020
    Publication date: November 26, 2020
    Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, ADASTRA PHARMACEUTICALS, INC.
    Inventors: Sameer AGNIHOTRI, Alberto BRONISCER, Ian F. POLLACK, Thomas M. ESTOK
  • Polymorphic form of TG02
    Patent number: 10544162
    Abstract: The present disclosure provides crystalline polymorphic forms of TG02 free base and TG02 acid addition salts, pharmaceutical compositions comprising crystalline polymorphic forms of TG02 free base and TG02 acid addition salts, and methods of treating cancer and other diseases in a patient with crystalline polymorphic forms of TG02 free base and TG02 acid addition salts.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: January 28, 2020
    Assignee: ADASTRA PHARMACEUTICALS, INC.
    Inventors: Robert K. Mansfield, Tracy Parrott