Abstract: Systems and methods for using, configuring, and manufacturing self-obscuring tamper-evident labels can include producing labels that have adhesive and non-adhesive sides. The non-adhesive side can be configured to receive printing such as machine-readable codes. The labels typically have multiple layers which can be configured for various tasks. For example, one layer can be configured as an irreversible void material that generates indicia upon receiving a certain tension associated with removal from a surface. Another layer may be configured to ease the removal of the label from a surface while another generates deformations under tension. The indicia, deformations, and machine-readable code printed on the non-adhesive side can be configured such that when activated, the indicia render the machine-readable code unreadable via machine.