Abstract: A multilayer protein film has a mass of greater than 0.5 ?g/cm2 and consists essentially of protein. A drug delivery device comprises the multilayer protein film onto which a pharmaceutically active agent can be loaded. A biomedical implant comprises an implant substrate and the multilayer protein film on at least a portion of the implant substrate surface. A method of making a multilayer protein film having a mass of greater than 0.5 ?g/cm2 comprises contacting a substrate with a protein solution at a temperature of from about 30° C. to about 95° C, wherein a multilayer protein film having a mass of greater than 0.5 ?g/cm2 is formed on the substrate.

Abstract: A multilayer protein film has a mass of greater than 0.5 ?g/cm2 and consists essentially of protein. A drug delivery device comprises the multilayer protein film onto which a pharmaceutically active agent can be loaded. A biomedical implant comprises an implant substrate and the multilayer protein film on at least a portion of the implant substrate surface. A method of making a multilayer protein film having a mass of greater than 0.5 ?g/cm2 comprises contacting a substrate with a protein solution at a temperature of from about 30° C. to about 95° C., wherein a multilayer protein film having a mass of greater than 0.5 ?g/cm2 is formed on the substrate.

Abstract: A drug delivery device for local administration of a solution or suspension of a drug, such as a bone modulating drug, to a bone surface, comprising a ductile, absorbent material comprising said drug and being of a shape adapted or adaptable to the bone surface. The drug delivery device may additionally comprise a support of a non-absorbent material and a handle piece. The bone modulating drug may be chosen from bisphosphonates, statins, growth factors, signaling proteins and bone morphogenic protein. The device may be used in peroperatively treating a bone surface by local administration to the surface of the drug.

Abstract: The present invention provides a non-clottable matrix on a solid support comprising immobilized and crosslinked fibrinogen. The matrix may further comprise, in and/or on the matrix, one or several biologically active compound(s) and/or pharmacological substance(s). The matrix may be composed of one or several fibrinogen layer(s). The solid support according to the present invention may be selected from the group consisting of orthopaedic devices, implants, stitches, stents, pins, screws, plates, and sutures.