Abstract: A mutated tau protein fragment and a use thereof are disclosed. The mutated tau protein fragment consists 12 amino acid residues and thus can easily be prepared. In addition, when the mutated tau protein fragment is injected into an individual as an antigen, a neutralizing antibody against the mutated tau protein is generated. Moreover, the mutated tau protein fragment reduces the aggregation of abnormal tau proteins. Accordingly, the mutated tau protein fragment can be effectively used for the prevention or treatment of degenerative neurological diseases.
Type:
Application
Filed:
February 12, 2021
Publication date:
August 26, 2021
Applicant:
ADEL INC.
Inventors:
Seung-Yong YOON, Na-Young Kim, Dong-Hou Kim
Abstract: The present invention relates to a mutated tau protein fragment and a use thereof. The mutated tau protein fragment of the present invention consists of 12 amino acids and thus can easily be prepared. In addition, when the mutated tau protein fragment is injected into an individual as an antigen, a neutralizing antibody against the mutated tau protein is generated. Moreover, the mutated tau protein fragment reduces the aggregation of abnormal tau proteins. Accordingly, the mutated tau protein fragment of the present invention can be effectively used for the prevention or treatment of degenerative neurological diseases.
Type:
Grant
Filed:
December 20, 2017
Date of Patent:
May 11, 2021
Assignee:
ADEL INC.
Inventors:
Seung-Yong Yoon, Na-Young Kim, Dong-Hou Kim
Abstract: The present invention relates to a mutated tau protein fragment and a use thereof. The mutated tau protein fragment of the present invention consists of 12 amino acids and thus can easily be prepared. In addition, when the mutated tau protein fragment is injected into an individual as an antigen, a neutralizing antibody against the mutated tau protein is generated. Moreover, the mutated tau protein fragment reduces the aggregation of abnormal tau proteins. Accordingly, the mutated tau protein fragment of the present invention can be effectively used for the prevention or treatment of degenerative neurological diseases.
Type:
Application
Filed:
December 20, 2017
Publication date:
October 31, 2019
Applicant:
ADEL INC.
Inventors:
Seung-Yong YOON, Na-Young KIM, Dong-Hou KIM