Abstract: A medical containment enclosure defines an internal chamber configured to receive at least part of a patient during a medical procedure, with the enclosure operable to fluidly connect to a suction device. The enclosure includes a containment housing, an access portal, and a suction port. The containment housing at least partly defines the chamber. The access portal defines an orifice that permits chamber ingress and egress. The suction port fluidly communicates with the chamber and is fluidly connectable to the suction device to permit the suction device to draw fluid from the chamber. The access portal restricts fluid flow through the orifice so that fluid removal by the suction device is operable to reduce an internal chamber pressure below an external pressure and thereby restrict aerosols from exiting the chamber via the access portal.