Patents Assigned to Aderans Research Institute, Inc.
  • Patent number: 10398736
    Abstract: Compositions and methods for producing reconstituted human skin and/or hair follicles in situ are provided. The method for producing the skin is unique in that tissue culture expanded cells including multipotent cells such as neonatal cells as well as cultured epidermal and dermal cells are immediately placed on a substrate such as a membrane and then the membrane with adherent cells is placed on a skin wound. Examples demonstrate formation of hair follicles in situ.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: September 3, 2019
    Assignee: ADERANS RESEARCH INSTITUTE, INC.
    Inventors: Xunwei Wu, Kurt Stenn, Larry Scott, Jr., Daniel J. Hussey
  • Patent number: 10398735
    Abstract: Compositions and methods for producing reconstituted human skin and/or hair follicles in situ are provided. The method for producing the skin is unique in that tissue culture expanded cells including multipotent cells such as neonatal cells as well as cultured epidermal and dermal cells are immediately placed on a substrate such as a membrane and then the membrane with adherent cells is placed on a skin wound. Examples demonstrate formation of hair follicles in situ.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: September 3, 2019
    Assignee: ADERANS RESEARCH INSTITUTE, INC.
    Inventors: Xunwei Wu, Kurt Stenn, Larry Scott, Jr., Daniel J. Hussey
  • Publication number: 20170252377
    Abstract: Compositions and methods for producing reconstituted human skin and/or hair follicles in situ are provided. The method for producing the skin is unique in that tissue culture expanded cells including multipotent cells such as neonatal cells as well as cultured epidermal and dermal cells are immediately placed on a substrate such as a membrane and then the membrane with adherent cells is placed on a skin wound. Examples demonstrate formation of hair follicles in situ.
    Type: Application
    Filed: May 17, 2017
    Publication date: September 7, 2017
    Applicant: ADERANS RESEARCH INSTITUTE, INC.
    Inventors: Xunwei WU, Kurt STENN, Larry SCOTT, Jr., Daniel J. HUSSEY
  • Publication number: 20170246213
    Abstract: Compositions and methods for producing reconstituted human skin and/or hair follicles in situ are provided. The method for producing the skin is unique in that tissue culture expanded cells including multipotent cells such as neonatal cells as well as cultured epidermal and dermal cells are immediately placed on a substrate such as a membrane and then the membrane with adherent cells is placed on a skin wound. Examples demonstrate formation of hair follicles in situ.
    Type: Application
    Filed: May 17, 2017
    Publication date: August 31, 2017
    Applicant: ADERANS RESEARCH INSTITUTE, INC.
    Inventors: Xunwei WU, Kurt STENN, Larry SCOTT, JR., Daniel J. HUSSEY
  • Patent number: 9655930
    Abstract: Compositions and methods for producing reconstituted human skin and/or hair follicles in situ are provided. The method for producing the skin is unique in that tissue culture expanded cells including multipotent cells such as neonatal cells as well as cultured epidermal and dermal cells are immediately placed on a substrate such as a membrane and then the membrane with adherent cells is placed on a skin wound. Examples demonstrate formation of hair follicles in situ.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: May 23, 2017
    Assignee: ADERANS RESEARCH INSTITUTE, INC.
    Inventors: Xunwei Wu, Kurt Stenn, Larry Scott, Jr., Daniel J. Hussey
  • Publication number: 20160206663
    Abstract: Compositions and methods for producing reconstituted human skin and/or hair follicles in situ are provided. The method for producing the skin is unique in that tissue culture expanded cells including multipotent cells such as neonatal cells as well as cultured epidermal and dermal cells are immediately placed on a substrate such as a membrane and then the membrane with adherent cells is placed on a skin wound. Examples demonstrate formation of hair follicles in situ.
    Type: Application
    Filed: October 21, 2013
    Publication date: July 21, 2016
    Applicant: Aderans Research Institute, Inc.
    Inventors: Xunwei Wu, Kurt Stenn, Larry Scott, JR., Daniel J. Hussey
  • Patent number: 9023380
    Abstract: The present invention provides a hair graft comprising (a) tissue engineered skin comprising a tissue engineered epidermal layer, a tissue engineered dermal layer, and hair follicle progenitor cells and (b) a scaffold. The invention also provides methods of making and using the hair grafts of the present invention.
    Type: Grant
    Filed: March 23, 2010
    Date of Patent: May 5, 2015
    Assignee: Aderans Research Institute, Inc.
    Inventors: Thomas H. Barrows, Preeti MacIntyre, Kenneth Justin Washenik
  • Publication number: 20150113672
    Abstract: Compositions and methods for producing reconstituted human skin and/or hair follicles in situ are provided. The method for producing the skin is unique in that tissue culture expanded cells including multipotent cells such as neonatal cells as well as cultured epidermal and dermal cells are immediately placed on a substrate such as a membrane and then the membrane with adherent cells is placed on a skin wound. Examples demonstrate formation of hair follicles in situ.
    Type: Application
    Filed: October 21, 2013
    Publication date: April 23, 2015
    Applicant: Aderans Research Institute, Inc.
    Inventors: Xunwei Wu, Kurt Stenn, Larry Scott, JR., Daniel J. Hussey
  • Patent number: 8980628
    Abstract: This invention relates to methods of producing hair folliclesin vitro, compositions for producing hair follicles in vitro, in vitro produced hair follicles, methods of providing an in vitro produced hair shaft at an interfollicular or intrafollicular site, methods of treating hair loss by providing an in vitro produced hair shaft at an interfollicular or intrafollicular site and assays for studying the effect of test agents on hair biology. The invention also provides the similar methods and products which are, or use, immature follicles (“defined herein as proto-hairs”). The invention provides a method for in vitro production of a hair follicle or a proto-hair comprising co-culturing dermal papilla cells with keratinocytes, and optionally with melanocytes.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: March 17, 2015
    Assignee: Aderans Research Institute, Inc.
    Inventors: Jizeng Qiao, Jeffrey Keeler Teumer, Erica Jean Philips
  • Patent number: 8206335
    Abstract: The present invention provides fluid and material delivery methods and devices for practicing the methods. The invention provides a method of delivering cellular material comprising injecting the cellular material into a subject such that the injected cells retain their inherent morphologic characteristics upon injection. The method comprises the steps of aspirating the cellular material into a fluid delivery device which incorporates a syringe arrangement. The cellular material is aspirated into the main body of the syringe until the desired amount of a material has filled the syringe body. The needle of the fluid delivery device is then inserted into the skin of a subject at an angle about parallel to the skin until a desired depth has been reached. The cellular material is then injected in the subject until the desired volume of material has been injected. The needle of the device is then rotated approximately 45 to 90 degrees and the needle is removed from the injection site.
    Type: Grant
    Filed: July 14, 2010
    Date of Patent: June 26, 2012
    Assignee: Aderans Research Institute, Inc.
    Inventors: Terrell Pruitt, Stephen A. Cochran, Bryan Marshall, Yandong Su
  • Patent number: 7985537
    Abstract: The present invention provides a method for determining hair inductive properties of a composition comprising injecting a composition comprising dissociated dermal cells and epidermal cells into skin of a mammal and determining whether at least one hair follicle forms.
    Type: Grant
    Filed: June 12, 2007
    Date of Patent: July 26, 2011
    Assignee: Aderans Research Institute, Inc.
    Inventors: Ying Zheng, Satish Parimoo, Kurt Stricker Stenn
  • Patent number: 7785876
    Abstract: The present invention relates to culturing cells which may be used in hair induction. In one aspect of the invention there is provided a method for cultivation of hair inductive cells, comprising the step of culturing the hair inductive cells in a culture medium comprising a medium conditioned by conditioning cells, in which the conditioning cells are derived from non-epidermal tissue.
    Type: Grant
    Filed: November 14, 2003
    Date of Patent: August 31, 2010
    Assignee: Aderans Research Institute, Inc.
    Inventors: Jeffrey Keller Teumer, Erica Philips, Richard Gregory Wolowacz, Jizeng Qiao
  • Patent number: 7780635
    Abstract: The present invention provides fluid and material delivery methods and devices for practicing the methods. The invention provides a method of delivering cellular material comprising injecting the cellular material into a subject such that the injected cells retain their inherent morphologic characteristics upon injection. The method comprises the steps of aspirating the cellular material into a fluid delivery device which incorporates a syringe arrangement. The cellular material is aspirated into the main body of the syringe until the desired amount of a material has filled the syringe body. The needle of the fluid delivery device is then inserted into the skin of a subject at an angle about parallel to the skin until a desired depth has been reached. The cellular material is then injected in the subject until the desired volume of material has been injected. The needle of the device is then rotated approximately 45 to 90 degrees and the needle is removed from the injection site.
    Type: Grant
    Filed: February 8, 2007
    Date of Patent: August 24, 2010
    Assignee: Aderans Research Institute, Inc.
    Inventors: Terrell Pruitt, Stephen A. Cochran, Bryan Marshall, Yandong Su, Kurt Stricker Stenn, Kenneth Justin Washenik, John DePiano, Gary F. Prokop, Martin Rathgeber
  • Patent number: 7597885
    Abstract: The present invention relates to an improved scaffold which is constructed to mimic the architecture of the native hair follicle. The present invention also relates to the use of specific compositions and methods of manufacture to produce scaffolds that combine biocompatibility with the desired rates of bioabsorption. In another embodiment, the present invention relates to a process for manufacturing a biomimetic hair follicle graft and a method for seeding the graft with cells and implanting the graft into the skin where the growth of a new hair shaft is desired. A further embodiment of the present invention relates to a method for hair multiplication in which cells are multiplied in culture and aliquoted into a multitude of bioabsorbable scaffolds in combination with cultured keratinocytes or other allogenic cells.
    Type: Grant
    Filed: March 26, 2004
    Date of Patent: October 6, 2009
    Assignee: Aderans Research Institute, Inc.
    Inventors: Thomas H. Barrows, Stephen A. Cochran, Bryan Marshall
  • Publication number: 20080311044
    Abstract: The present invention provides a method for determining hair inductive properties of a composition comprising injecting a composition comprising dissociated dermal cells and epidermal cells into skin of a mammal and determining whether at least one hair follicle forms.
    Type: Application
    Filed: June 12, 2007
    Publication date: December 18, 2008
    Applicant: Aderans Research Institute, Inc.
    Inventors: Ying Zheng, Satish Parimoo, Kurt Stricker Stenn
  • Publication number: 20070233038
    Abstract: The present invention provides fluid and material delivery methods and devices for practicing the methods. The invention provides a method of delivering cellular material comprising injecting the cellular material into a subject such that the injected cells retain their inherent morphologic characteristics upon injection. The method comprises the steps of aspirating the cellular material into a fluid delivery device which incorporates a syringe arrangement. The cellular material is aspirated into the main body of the syringe until the desired amount of a material has filled the syringe body. The needle of the fluid delivery device is then inserted into the skin of a subject at an angle about parallel to the skin until a desired depth has been reached. The cellular material is then injected in the subject until the desired volume of material has been injected. The needle of the device is then rotated approximately 45 to 90 degrees and the needle is removed from the injection site.
    Type: Application
    Filed: February 8, 2007
    Publication date: October 4, 2007
    Applicant: ADERANS RESEARCH INSTITUTE, INC.
    Inventors: Terrell Pruitt, Stephen Cochran, Bryan Marshall, Yandong Su, Kurt Stenn, Kenneth Washenik, John DePiano, Gary Prokop, Martin Rathgeber
  • Publication number: 20070148138
    Abstract: The present invention provides a hair graft comprising (a) tissue engineered skin comprising a tissue engineered epidermal layer, a tissue engineered dermal layer, and hair follicle progenitor cells and (b) a scaffold. The invention also provides methods of making and using the hair grafts of the present invention.
    Type: Application
    Filed: November 22, 2006
    Publication date: June 28, 2007
    Applicant: ADERANS RESEARCH INSTITUTE, INC.
    Inventors: Thomas Barrows, Preeti MacIntyre, Kenneth Washenik
  • Publication number: 20070122387
    Abstract: The present invention is a hair graft derived from a plucked hair comprising a plucked hair having adhered epidermal stem cells and associated follicular dermal cells. The present invention also includes methods of making a hair graft, methods of implanting a hair graft and methods of identifying inductive follicular dermal cells.
    Type: Application
    Filed: November 22, 2006
    Publication date: May 31, 2007
    Applicant: Aderans Research Institute, Inc.
    Inventors: Stephen Cochran, Bryan Marshall, Thomas Barrows, Yandong Su, Robyn Schlicher
  • Patent number: D606190
    Type: Grant
    Filed: September 16, 2008
    Date of Patent: December 15, 2009
    Assignee: Aderans Research Institute, Inc.
    Inventors: Terrell Pruitt, Stephen A. Cochran, Bryan Marshall, Yandong Su, John DePiano, Gary F. Prokop, Martin Rathgeber, Kenneth Justin Washenik
  • Patent number: D690004
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: September 17, 2013
    Assignee: Aderans Research Institute, Inc.
    Inventors: Terrell Pruitt, Yandong Su, Bryan Marshall, Stephen Cochran, Joseph Suarez