Abstract: A DNA fragment coding for a modified nuclear glucocorticoid receptor, particularly one mutated in the region coding for the ligand binding domain, so that receptor activity is more strongly inducible by a synthetic glucocorticoid ligand than by a natural glucocorticoid ligand, is disclosed. A recombination system inducible in mammals by means of a fusion protein produced between a recombinase and the binding domain of the ligand derived from the modified glucocorticoid receptor of which the activity is more strongly inducible by synthetic glucocorticoids than by natural glucocorticoids, is also disclosed.
Type:
Grant
Filed:
August 20, 1998
Date of Patent:
March 2, 2004
Assignee:
Association pour le Development de la Recherche en Genetique
Moleculaire (ADEREGEM)
Inventors:
Jacques Bertrand Brocard, Pierre Henri Chambon, Hinrich Gronemeyer, Daniel Metzger, Jean-Claude Nicolas, Sylvie Roux
Abstract: The present invention deals with a protein activation of CREM in Testis named ACT, the cDNA encoding ACT and a method to select compounds which are able to interact with ACT or its site of interaction on CREM to block or stimulate the CREM transcriptional activity in Testis. Such compounds may be useful to control male fertility.
Type:
Grant
Filed:
March 10, 2000
Date of Patent:
December 9, 2003
Assignee:
Association pour le Developpement de la Recherche en
Genetique Moleculaire (ADEREGEM)
Abstract: Peptides derived from the pS2 protein and polyclonal and monoclonal antibodies directed against pS2 and against pS2 fragments. Method of obtaining the secreted from of the pS2 protein and fragments thereof. Method of detecting and diagnosing different pathological conditions and especially hormone-dependent breast cancers and pathological conditions of the stomach.
Type:
Grant
Filed:
December 10, 1992
Date of Patent:
June 3, 1997
Assignee:
Aderegem
Inventors:
Pierre Chambon, Marie-Christine nee Martinet Rio, Jean-Pierre Bellocq
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