Patents Assigned to Adhesys Medical GmbH
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Patent number: 10722609Abstract: The present invention relates to a method that includes providing a formulation having an isocyanate-functional prepolymer and a curing component comprising an amino-functional aspartic ester of the general formula (I) applying the formulation to a cell tissue; and curing the formulation such that the loss of blood (haemostatic) or tissue fluids is staunched or leaks in cell tissues are sealed.Type: GrantFiled: June 25, 2019Date of Patent: July 28, 2020Assignee: Adhesys Medical GmbHInventors: Heike Heckroth, Burkhard Köhler, Sebastian Dörr
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Patent number: 10633481Abstract: Polyurea systems comprising: (a) an amino-functional aspartic ester of the general formula (I) wherein X represents an n-valent organic radical derived from a corresponding n-functional primary amine X(NH2)n, R1 and R2 each independently represent an organic radical having no Zerevitinov active hydrogens and n represents an integer of at least 2; and (b) an isocyanate functional prepolymer having a residual monomer content of less than 1% by weight, the prepolymer prepared by reacting: (b1) an aliphatic isocyante; and (b2) a polyol component having a number average molecular weight of ?400 g/mol and an average OH functionality of 2 to 6, wherein the polyol component comprises one or more constituents selected from the group consisting of polyester polyols, polyester-polyether polyols and mixtures thereof; processes for making the same; postoperative adhesions barriers prepared therewith and dispensing systems for such polyurea systems.Type: GrantFiled: March 2, 2015Date of Patent: April 28, 2020Assignee: Adhesys Medical GmbHInventors: Heike Heckroth, Hartmut Nefzger, Christian Wamprecht
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Publication number: 20200046875Abstract: The present invention relates to a method that includes providing a formulation having an isocyanate-functional prepolymer and a curing component comprising an amino-functional aspartic ester of the general formula (I) applying the formulation to a cell tissue; and curing the formulation such that the loss of blood (haemostatic) or tissue fluids is staunched or leaks in cell tissues are sealed.Type: ApplicationFiled: June 25, 2019Publication date: February 13, 2020Applicant: Adhesys Medical GmbHInventors: Heike Heckroth, Burkhard KÖHLER, Sebastian DÖRR
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Patent number: 10391198Abstract: The present invention relates to a method that includes providing a formulation having an isocyanate-functional prepolymer and a curing component comprising an amino-functional aspartic ester of the general formula (I) applying the formulation to a cell tissue; and curing the formulation such that the loss of blood (haemostatic) or tissue fluids is staunched or leaks in cell tissues are sealed.Type: GrantFiled: October 1, 2018Date of Patent: August 27, 2019Assignee: Adhesys Medical GmbHInventors: Heike Heckroth, Burkhard Köhler, Sebastian Dörr
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Patent number: 10117963Abstract: The present invention relates to a method that includes providing a formulation having an isocyanate-functional prepolymer and a curing component comprising an amino-functional aspartic ester of the general formula (I) applying the formulation to a cell tissue; and curing the formulation such that the loss of blood (haemostatic) or tissue fluids is staunched or leaks in cell tissues are sealed.Type: GrantFiled: August 3, 2017Date of Patent: November 6, 2018Assignee: Adhesys Medical GmbHInventors: Heike Heckroth, Burkhard Köhler, Sebastian Dörr
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Patent number: 9764058Abstract: The present invention relates to a method that includes providing a formulation having an isocyanate-functional prepolymer and a curing component comprising an amino-functional aspartic ester of the general formula (I) applying the formulation to a cell tissue; and curing the formulation such that the loss of blood (haemostatic) or tissue fluids is staunched or leaks in cell tissues are sealed.Type: GrantFiled: July 4, 2009Date of Patent: September 19, 2017Assignee: Adhesys Medical GmbHInventors: Heike Heckroth, Burkhard Köhler, Sebastian Dörr
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Patent number: 9757492Abstract: The present invention relates to a process for producing a hydroxy amino polymer comprising the steps: a) Reaction of an H functional starter compound bearing at least one Zerewitinoff active H atom with an unsaturated, cyclical carboxylic acid anhydride and at least one alkylene oxide compound for obtaining a prepolymer bearing hydroxyl groups, b) Addition of a primary amine and/or of ammonia to the double bond(s) of the prepolymer bearing hydroxyl groups obtained according to step a) for obtaining the hydroxy amino polymer, wherein the ratio of added amino groups to hydroxyl groups in a hydroxy amino polymer is at least 0.6. Furthermore, the invention relates to a hydroxy amino polymer, which can be achieved according to this process as well as a polyurea/polyurethane system, which contains such a hydroxy amino polymer.Type: GrantFiled: January 10, 2017Date of Patent: September 12, 2017Assignee: Adhesys Medical GmbHInventors: Heike Heckroth, Christoph Eggert, Jörg Hofmann, Klaus Lorenz, Edward Browne, Hartmut Nefzger
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Patent number: 9717819Abstract: The present invention relates to a polyurea system, the use of such a polyurea system for sealing, linking, gluing, or covering of cellular tissue, and a dosing system having two chambers for a polyurea system such as this. The polyurea system comprises as components: A) an isocyanate-functioning prepolymer, which can be derived by reacting aliphatic isocyanates with polyoles, and B) an amino-functioning ester of aspartic acid. According to the invention, water and/or tertiary amine is added to the system, in order to increase the reacting speed of the prepolymer with the amino-functioning ester of aspartic acid while decreasing the setting time at the same time.Type: GrantFiled: June 24, 2016Date of Patent: August 1, 2017Assignee: Adhesys Medical GmbHInventors: Heike Heckroth, Hartmut Nefzger, Christoph Eggert
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Patent number: 9580540Abstract: The present invention relates to a process for producing a hydroxy amino polymer comprising the steps: a) Reaction of an H functional starter compound bearing at least one Zerewitinoff active H atom with an unsaturated, cyclical carboxylic acid anhydride and at least one alkylene oxide compound for obtaining a prepolymer bearing hydroxyl groups, b) Addition of a primary amine and/or of ammonia to the double bond(s) of the prepolymer bearing hydroxyl groups obtained according to step a) for obtaining the hydroxy amino polymer, wherein the ratio of added amino groups to hydroxyl groups in a hydroxy amino polymer is at least 0.6. Furthermore, the invention relates to a hydroxy amino polymer, which can be achieved according to this process as well as a polyurea/polyurethane system, which contains such a hydroxy amino polymer.Type: GrantFiled: December 17, 2012Date of Patent: February 28, 2017Assignee: Adhesys Medical GmbHInventors: Heike Heckroth, Christoph Eggert, Jörg Hofmann, Klaus Lorenz, Edward Browne, Hartmut Nefzger
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Patent number: 9468701Abstract: The present invention relates to an isocyanate functional prepolymer that can be achieved through a) a reaction of an H functional starter compound having at least one Zerewitinoff active H atom with an alkylene oxide and a comonomer to a preliminary stage bearing hydroxyl groups, wherein said comonomer is selected from the group comprising lactides, glycolides, cyclical dicarboxylic acid anhydrides as well as combinations thereof and wherein said comonomer is integrated through statistical copolymerization into the polymer chain(s) of the preliminary stage bearing hydroxyl groups, and b) a reaction of the preliminary stage bearing hydroxyl groups from step a) with a polyfunctional isocyanate to an isocyanate functional prepolymer. The invention additionally relates to a process for producing this isocyanate functional prepolymer, a tissue adhesive system containing such an isocyanate functional prepolymer and a dispensing system having at least two chambers and this type of tissue adhesive system.Type: GrantFiled: May 16, 2016Date of Patent: October 18, 2016Assignee: Adhesys Medical GmbHInventors: Heike Heckroth, Christoph Eggert, Jörg Hofmann, Klaus Lorenz
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Patent number: 9421298Abstract: The invention relates to a polyurea system comprising as component A) isocyanate-functional prepolymers which can be obtained by reacting aliphatic isocyanates A1) with polyols A2) that can have a number-average molecular weight of =400 g/mol and an average OH functionality of 2 to 6 in particular; and as component B) amino-functional aspartic acid esters of the general formula (I) in which X is an organic group containing a secondary amino function, R1, R2 are the same or different organic groups that do not have Zerewitinoff-active hydrogen, and n is a whole number of at least 2, in particular for sealing, bonding, gluing, or covering cell tissue. The invention also relates to a metering system for the polyurea system according to the invention.Type: GrantFiled: February 6, 2012Date of Patent: August 23, 2016Assignee: Adhesys Medical GmbHInventors: Heike Heckroth, Christoph Eggert
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Patent number: 9404026Abstract: The present invention relates to a polyurea system, the use of such a polyurea system for sealing, linking, gluing, or covering of cellular tissue, and a dosing system having two chambers for a polyurea system such as this. The polyurea system comprises as components: A) an isocyanate-functioning prepolymer, which can be derived by reacting aliphatic isocyanates with polyoles, and B) an amino-functioning ester of aspartic acid. According to the invention, water and/or tertiary amine is added to the system, in order to increase the reacting speed of the prepolymer with the amino-functioning ester of aspartic acid while decreasing the setting time at the same time.Type: GrantFiled: May 4, 2015Date of Patent: August 2, 2016Assignee: Adhesys Medical GmbHInventors: Heike Heckroth, Hartmut Nefzger, Christoph Eggert
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Patent number: 9393345Abstract: The present invention relates to a polyurea system comprising as component A) isocyanate-functional prepolymers obtainable by reaction of aliphatic isocyanates A1) with polyols A2), which in particular can have a number-average molecular weight of ?400 g/mol and a mean OH functionality of from 2 to 6, as component B) an amino-functional compound of the general formula (I) in which X is an organic radical containing a secondary amino function, Y is an organic radical that contains a tertiary amino group and does not contain Zerewitinoff-active hydrogen, R1 is a CH2—COOR3 radical in which R3 is an organic radical that does not contain Zerewitinoff-active hydrogen, a linear or branched C1- to C4-alkyl radical, a cyclopentyl radical, a cyclohexyl radical or H, R2 is an organic radical that does not contain Zerewitinoff-active hydrogen, a is 1 or 2, b is 1 or 2, and a+b=2 or 3, for stemming the escape of blood, and to a metering system for the polyurea system according to the invention.Type: GrantFiled: April 17, 2012Date of Patent: July 19, 2016Assignee: Adhesys Medical GmbHInventors: Heike Heckroth, Christoph Eggert