Abstract: The present invention relates to methods for the selective expansion of ?? T-cell population(s), compositions and admixtures thereof and methods for using the same as a therapeutic. Non-engineered and engineered, enriched ?? T-cell populations of the disclosure are useful in the treatment of various cancers, infectious diseases, and immune disorders.
Type:
Grant
Filed:
May 12, 2017
Date of Patent:
April 12, 2022
Assignee:
ADICET BIO, INC.
Inventors:
Aya Jakobovits, Orit Foord, Andy An-deh Lin, Marianne Theresa Santaguida, Radhika Chetan Desai, Yifeng Frank Jing, Daulet Kadyl Satpayev, Yan Li
Abstract: The present invention relates to engineered ?? T-cell(s) and methods for using the same as a therapeutic with a potent and selective ability to target an antigen of choice. Engineered ?? T-cells of the disclosure are useful in the treatment of various cancers, infectious diseases, and immune disorders. Also disclosed are methods for expanding engineered and non-engineered ?? T-cell(s) populations to therapeutically useful quantities. An engineered ?? T-cell of the disclosure can be a universal donor, and can be administered to a subject with any MHC haplotype.
Type:
Grant
Filed:
November 17, 2015
Date of Patent:
October 5, 2021
Assignee:
ADICET BIO, INC.
Inventors:
Aya Jakobovits, Orit Foord, Andy An-deh Lin, Marianne Theresa Santaguida