Abstract: The invention features methods of obtaining high-yield, essentially pure human predipocyte cultures. Cultures obtained according to the instant methodology are also featured as are methods of identifying adipogenic modulatory agents, e.g., high-throughput screening assays.
Abstract: Methods of identifying insulin response modulators are provided. Therapeutic methods utilizing compounds identified according to the methods of the invention are also provided. In particular, methods of treating diabetes and insulin resistance are provided.
Abstract: The present invention pertains to compounds effective at modulating fatty acid or triglyceride (“fat”) accumulation by cells, such compounds having therapeutic potential as regulators of body mass and for the treatment of overweight individuals, obesity, and metabolic disorders. Featured compounds are set forth and exemplified herein. Therapeutic methods and pharmaceutical compositions featuring these compounds are also provided.
Type:
Application
Filed:
July 22, 2002
Publication date:
July 31, 2003
Applicant:
AdipoGenix, Inc.
Inventors:
Michael John Stevenson, Harrison Jefferson Leighton
Abstract: The present invention pertains to compounds effective at modulating fatty acid or triglyceride accumulation by fat cells, such compounds having therapeutic potential as regulators of body mass and for the treatment of overweight individuals, obesity, and metabolic disorders.
Type:
Application
Filed:
August 8, 2002
Publication date:
July 10, 2003
Applicant:
AdipoGenix, Inc.
Inventors:
Michael John Stevenson, Harry Jefferson Leighton