Patents Assigned to ADIR
  • Patent number: 4644008
    Abstract: Compounds of the general formula: ##STR1## wherein: the ring A is saturated and n=0 or 1, orthe ring A is a benzene ring and n=1,R.sub.1 represents a lower alkyl group which can carry an amino group,R.sub.2 represents a hydrogen atom or a lower alkyl group,R.sub.3 represents a straight or branched alkyl group, a mono- or di-cycloalkylalkyl or phenylalkyl group having no more than a total of 9 carbon atoms, or a substituted alkyl group, and also the salts thereof.These compounds are useful as therapeutic drugs.
    Type: Grant
    Filed: October 10, 1984
    Date of Patent: February 17, 1987
    Assignee: Adir
    Inventors: Michel Vincent, Georges Remond, Michel Laubie
  • Patent number: 4616030
    Abstract: Compounds of the general formula: ##STR1## wherein: the ring A is saturated and n=0 or 1, orthe ring A is a benzene ring and n=1,R.sub.1 represents a lower alkyl group which can carry an amino group,R.sub.2 represents a hydrogen atom or a lower alkyl group,R.sub.3 represents a straight or branched alkyl group, a mono- or di-cycloalkylalkyl or phenylalkyl group having no more than a total of 9 carbon atoms, or a substituted alkyl group, and also the salts thereof.These compounds are useful as therapeutic drugs.
    Type: Grant
    Filed: December 6, 1984
    Date of Patent: October 7, 1986
    Assignee: ADIR
    Inventors: Michel Vincent, Georges Remond, Michel Laubie
  • Patent number: 4616031
    Abstract: Compounds of the general formula: ##STR1## wherein: the ring A is saturated and n=0 or 1, orthe ring A is a benzene ring and n=1,R.sub.1 represents a lower alkyl group which can carry an amino group,R.sub.2 represents a hydrogen atom or a lower alkyl group,R.sub.3 represents a straight or branched alkyl group, a mono- or di-cycloalkylalkyl or phenylalkyl group having no more than a total of 9 carbon atoms, or a substituted alkyl group, and also the salts thereof.These compounds are useful as thereapeutic drugs.
    Type: Grant
    Filed: October 10, 1984
    Date of Patent: October 7, 1986
    Assignee: ADIR
    Inventors: Michel Vincent, Georges Remond, Michel Laubie
  • Patent number: 4616029
    Abstract: Compounds of the general formula: ##STR1## wherein: the ring A is saturated and n=0 or 1, orthe ring A is a benzene ring and n=1,R.sub.1 represents a lower alkyl group which can carry an amino group,R.sub.2 represents a hydrogen atom or a lower alkyl group,R.sub.3 represents a straight or branched alkyl group, a mono- or di-cycloalkylalkyl or phenylalkyl group having no more than a total of 9 carbon atoms, or a substituted alkyl group, and also the salts thereof.These compounds are useful as therapeutic drugs.
    Type: Grant
    Filed: October 10, 1984
    Date of Patent: October 7, 1986
    Assignee: ADIR
    Inventors: Michel Vincent, Georges Remond, Michel Laubie
  • Patent number: 4565819
    Abstract: Compounds of the general formula: ##STR1## wherein: the ring A is saturated and n=0 or 1, orthe ring A is a benzene ring and n=1,R.sub.1 represents a lower alkyl group which can carry an amino group,R.sub.2 represents a hydrogen atom or a lower alkyl group,R.sub.3 represents a straight or branched alkyl group, a mono- or di-cycloalkylalkyl or phenylalkyl group having no more than a total of 9 carbon atoms, or a substituted alkyl group, and also the salts thereof.These compounds are useful as therapeutic drugs.
    Type: Grant
    Filed: September 20, 1982
    Date of Patent: January 21, 1986
    Assignee: ADIR
    Inventors: Michel Vincent, Georges Remond, Michel Laubie
  • Patent number: 4548820
    Abstract: New xanthine compounds of the formula: ##STR1## in which: R.sub.1 is hydrogen or alkyl from C.sub.1 to C.sub.5 inclusive;R.sub.2 is a hydrocarbon radical up to C.sub.6 having optionally a double bond, phenyl or benzyl;R.sub.3 is hydrogen, alkyl, hydroxyalkyl or dihydroxyalkyl each from C.sub.1 to C.sub.5R.sub.4 represents: ##STR2## in which: Y is hydrogen, halogen, alkyl or alkoxy from C.sub.1 to C.sub.5 or hydroxyl;Z is methylene or a straight or branched hydrocarbon radical from C.sub.2 to C.sub.5 optionally substituted by hydroxyl; andA is an amino group of the formula: ##STR3## p being 2 or 3; ##STR4## in which q is 1 or 2, and X is a single bond, oxygen or ##STR5## in which R.sub.5 is hydrogen, alkyl or alkylene up to C.sub.5, or ##STR6## in which m is an integer from 2 to 6 and R.sub.6 is alkyl from C.sub.1 to C.sub.5.
    Type: Grant
    Filed: July 25, 1983
    Date of Patent: October 22, 1985
    Assignee: Adir
    Inventors: Gilbert Regnier, Claude Guillonneau, Jacques Duhault, Michelle Boulanger
  • Patent number: 4529729
    Abstract: Piperazine and homopiperazine compounds of the formula: ##STR1## in which: A is a hydrocarbon radical from C.sub.3 to C.sub.5, in a straight or branched chain, which may contain one or two double bonds, and optionally substituted by one or more OH;B is CH or a nitrogen atom;m is 2 or 3;X--Y-- represents --CH.dbd.CH--(CR'R").sub.n - in which n is zero or 1, and R' and R" are hydrogen or methyl;Z is oxygen or sulfur,R is hydrogen, alkyl from C.sub.1 to C.sub.5, cycloalkyl from C.sub.3 to C.sub.7, or phenyl optionally substituted by fluorine, chlorine or alkyl from C.sub.1 to C.sub.5, andT is hydrogen, fluorine, chlorine or alkyl from C.sub.1 to C.sub.5.These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of all kinds of tissular hypoxia.
    Type: Grant
    Filed: June 20, 1984
    Date of Patent: July 16, 1985
    Assignee: Adir
    Inventors: Gilbert Regnier, Michel Laubie, Jacques Duhault
  • Patent number: 4514398
    Abstract: Polymethylene-imines of the formula: ##STR1## in which: A is a hydrocarbon radical from C.sub.3 to C.sub.5 in a straight or branched chain possibly containing one or two double bonds and possibly substituted by one or more hydroxy radicals;X is CH or nitrogen;n is zero, one or two;Y is oxygen or N--R.sub.1 in which R.sub.1 is hydrogen, alkyl from C.sub.1 to C.sub.5, alkenyl from C.sub.2 to C.sub.5, cycloalkyl or cycloalkenyl from C.sub.3 to C.sub.7, or acetyl;R is hydrogen, alkyl from C.sub.1 to C.sub.5, cycloalkyl from C.sub.5 to C.sub.7 or phenyl optionally substituted by one or more fluorine or chlorine; andB is hydrogen, alkyl from C.sub.1 to C.sub.5, alkenyl from C.sub.2 to C.sub.5, or phenyl, naphthyl, benzofuranyl, benzothienyl, benzodioxolyl, benzodioxanyl, benzodioxinyl, .DELTA.3-chromanyl, thiochromenyl or chromanyl, each optionally substituted by fluorine, chlorine, alkyl or alkoxy from C.sub.1 to C.sub.5 ; ora radical of the formula: ##STR2## in which: R.sub.2, R.sub.3 and R.sub.
    Type: Grant
    Filed: March 25, 1983
    Date of Patent: April 30, 1985
    Assignee: ADIR
    Inventors: Gilbert Regnier, Alain Dhainaut, Michel Laubie, Jacques Duhault
  • Patent number: 4514399
    Abstract: N,N'-substituted polymethylene diamines of the formula: ##STR1## in which: A is a hydrocarbon radical from C.sub.3 to C.sub.5 in a straight or branched chain optionally containing one and two double bonds and possibly substituted by one or more hydroxy radicals;X is CH or nitrogen;n is an integer from 2 to 6;R.sub.1 is hydrogen, or alkyl from C.sub.1 to C.sub.5 ;R.sub.2 is hydrogen, alkyl from C.sub.1 to C.sub.5, cycloalkyl from C.sub.5 to C.sub.7, or phenyl optionally substituted by one or more fluorine or chlorine, andB is:phenyl, naphthyl, benzofuranyl, benzothionyl, benzodioxolyl, benzodioxanyl, benzodioxinyl, .DELTA.3-chromenyl, thiochromenyl or chromanyl, each of them optionally substituted by fluorine, chlorine, alkyl or alkoxy from C.sub.1 to C.sub.5, or methylene-dioxy, ora radical of the formula: ##STR2## in which R.sub.3, R.sub.4 and R.sub.5 which may be the same or different, each represent hydrogen or phenyl optionally substituted by fluorine or chlorine.
    Type: Grant
    Filed: April 18, 1983
    Date of Patent: April 30, 1985
    Assignee: Adir
    Inventors: Gilbert Regnier, Alain Dhainaut, Michel Laubie, Jacques Duhault
  • Patent number: 4508729
    Abstract: Compounds of the general formula: ##STR1## wherein: the ring A is saturated and n=0 or 1, orthe ring A is a benzene ring and n=1,R.sub.1 represents a lower alkyl group which can carry an amino group,R.sub.2 represents a hydrogen atom or a lower alkyl group,R.sub.3 represents a straight or branched alkyl group, a mono- or di-cycloalkylalkyl or phenylalkyl group having no more than a total of 9 carbon atoms, or a substituted alkyl group, and also the salts thereof.These compounds are useful as therapeutic drugs.
    Type: Grant
    Filed: October 2, 1981
    Date of Patent: April 2, 1985
    Assignee: Adir
    Inventors: Michel Vincent, Georges Remond, Michel Laubie
  • Patent number: 4496557
    Abstract: Compounds corresponding to the general formula: ##STR1## in which X and Y identical or different, represent a hydrogen or a halogen atom, a lower alkyl, a lower alkoxy or a trifluormethyl group,A represents a methylene group, a direct bond or an imino--NR.sub.3 -- group in which R.sub.3 is a hydrogen atom or a lower alkyl or lower alkanoyl groupR.sub.1 and R.sub.2 identical or different, each represents a hydrogen atom or a lower alkyl group, or together with the nitrogen atom to which they are attached they form a pyrrolidino, piperidino or methyl-4 piperazine group, andn represents an integer from 1 to 3, in their racemic or optical isomeric forms, as well as their salts of addition with a therapeutically compatible mineral or organic acid.These compounds are useful as antidepressants.
    Type: Grant
    Filed: August 16, 1982
    Date of Patent: January 29, 1985
    Assignee: Adir
    Inventors: Charles Malen, Jean-Claude Poignant
  • Patent number: 4492696
    Abstract: Piperazine and homopiperazine compounds of the formula: ##STR1## in which: A is a hydrocarbon radical from C.sub.3 to C.sub.5, in a straight or branched chain, which may contain one or two double bonds, and optionally substituted by one or more OH;B is CH or a nitrogen atom;m is 2 or 3;X--Y-- represents --CH.dbd.CH-- (CR'R").sub.n -- in which n is zero or 1, and R' and R" are hydrogen or methyl;Z is oxygen or sulfur,R is hydrogen, alkyl from C.sub.1 to C.sub.5, cycloalkyl from C.sub.3 to C.sub.7, or phenyl optionally substituted by fluorine, chlorine or alkyl from C.sub.1 to C.sub.5, andT is hydrogen, fluorine, chlorine or alkyl from C.sub.1 to C.sub.5.These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of all kinds of tissular hypoxy.
    Type: Grant
    Filed: February 15, 1983
    Date of Patent: January 8, 1985
    Assignee: ADIR
    Inventors: Gilbert Reginier, Michel Laubie, Jacques Duhault