Patents Assigned to Adocia
  • Publication number: 20140235536
    Abstract: A composition in the form of an injectable aqueous solution, the pH of which is from 6.6 to 7.8, comprises at least: a) a basal insulin, the isoelectric point pI of which is between 5.8 and 8.5; and b) an anionic compound bearing carboxylate charges and hydrophobic radicals. The composition may also include a prandial insulin.
    Type: Application
    Filed: February 12, 2014
    Publication date: August 21, 2014
    Applicant: ADOCIA
    Inventors: Olivier SOULA, Richard CHARVET, Alexandre GEISSLER
  • Patent number: 8669227
    Abstract: The invention relates to a complex between an insulin and a polysaccharide comprising carboxyl functional groups, said polysaccharide being chosen from polysaccharides functionalized with at least one phenylalanine derivative, noted Phe, said phenylalanine derivative being chosen from the group consisting of phenylalanine and its alkali metal cation salts, phenylalaninol, phenylalaninamide and ethylbenzylamine or from phenylalanine esters, and said insulin being either a human insulin or an insulin analog. The invention also relates to a pharmaceutical composition comprising at least one complex according to the invention, especially in the form of an injectable solution.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: March 11, 2014
    Assignee: Adocia
    Inventors: Olivier Soula, Remi Soula, Gerard Soula
  • Patent number: 8629124
    Abstract: The invention relates to a dextran functionalized by at least one hydrophobic alpha-amino acid radical, said alpha-amino acid being grafted or bonded to the dextran by a bonding arm and a functional group. A hydrophobic amino acid radical is understood as being the product of coupling between the amine of the amino acid and an acid carried by the bonding arm, said dextran being amphiphilic at neutral pH. In an embodiment, the hydrophobic amino acid is selected from tryptophan derivatives, such as tryptophan, tryptophanol, tryptophanamide, 2-indole ethyl-amine and their alkaline cation salts. The present invention relates also to a pharmaceutical composition comprising one of the dextrans according to the invention.
    Type: Grant
    Filed: March 31, 2008
    Date of Patent: January 14, 2014
    Assignee: Adocia
    Inventors: Gerard Soula, Olivier Soula, Remi Soula
  • Patent number: 8546356
    Abstract: Osteogenic compositions composed of a coprecipitate that contains at least one insoluble calcium salt and at least one complex between an osteogenic protein and a polysaccharide, the coprecipitate being in divided form, are described. Kits are also described, as are a process for preparing the coprecipitate in divided form, containing at least one insoluble calcium salt and at least one complex between an osteogenic protein and a polysaccharide.
    Type: Grant
    Filed: November 19, 2009
    Date of Patent: October 1, 2013
    Assignee: ADOCIA
    Inventors: Olivier Soula, Remi Soula, Gerard Soula
  • Publication number: 20130245246
    Abstract: A polysaccharide comprising carboxyl functional groups, at least one of which is substituted with at least one hydrophobic radical: the hydrophobic radical being a residue of a hydrophobic alcohol having a linear, branched or cyclic alkyl chain containing at least 6 carbon atoms, the hydrophobic radical being bonded to a linker arm R by a function G, the linker arm R being bonded to a carboxyl function of the polysaccharide by a bond F, R being an at least divalent radical of a chain including between 1 and 15 carbons, which is optionally branched and/or unsaturated, optionally including one or more heteroatoms, chosen amongst O, N and/or S, F being an amide function, G being a carbamate function, the unsubstituted carboxyl functions of the polysaccharide being in the form of a cation carboxylate, said cation being chosen amongst alkali metal cation.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 19, 2013
    Applicant: ADOCIA
    Inventors: Remi Soula, Olivier Soula, Gerard Soula, Richard Charvet, David Duracher
  • Publication number: 20130231281
    Abstract: A composition in aqueous solution, including an insulin and at least one oligosaccharide whose average degree of polymerization is between 3 and 13 and whose polydispersity index PDI is above 1.0, the oligosaccharide having partially substituted carboxyl functional groups, the unsubstituted carboxyl functional groups being salifiable.
    Type: Application
    Filed: November 2, 2012
    Publication date: September 5, 2013
    Applicant: ADOCIA
    Inventors: Olivier SOULA, Remi SOULA, Gerard SOULA
  • Patent number: 8497253
    Abstract: Osteogenic compositions composed of a coprecipitate that contains at least one insoluble calcium salt and at least one complex between an osteogenic protein and a polysaccharide, the coprecipitate being in divided form, are described. Kits are also described, as are a process for preparing the coprecipitate in divided form, containing at least one insoluble calcium salt and at least one complex between an osteogenic protein and a polysaccharide.
    Type: Grant
    Filed: November 19, 2009
    Date of Patent: July 30, 2013
    Assignee: Adocia
    Inventors: Olivier Soula, Remi Soula, Gerard Soula
  • Publication number: 20130178415
    Abstract: A composition in the form of an injectable aqueous solution, the pH of which is between 6.0 and 8.0, including at least (a) a basal insulin, the isoelectric point pI of which is between 5.8 and 8.5; and (b) a co-polyamino acid bearing carboxylate charges and substituted with hydrophobic radicals. In one embodiment, the compositions also include a prandial insulin and/or a gut hormone.
    Type: Application
    Filed: January 9, 2013
    Publication date: July 11, 2013
    Applicant: ADOCIA
    Inventor: ADOCIA
  • Patent number: 8426382
    Abstract: The invention relates to a polysaccharide comprising carboxyl functional groups, one at least of which is substituted by a derivative of a hydrophobic alcohol. The invention also relates to a pharmaceutical composition comprising one of the polysaccharides according to the invention and at least one active principle. It also relates to a pharmaceutical composition, wherein the active principle is chosen from the group consisting of proteins, glycoproteins, peptides and nonpeptide therapeutic molecules. The invention also relates to the use of the functionalized polysaccharides according to the invention in the preparation of pharmaceutical compositions as described above.
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: April 23, 2013
    Assignee: Adocia
    Inventors: Remi Soula, Olivier Soula, Gerard Soula, Richard Charvet
  • Publication number: 20130065826
    Abstract: A composition in the form of an injectable aqueous solution, the pH of which is between 6.0 and 8.0, includes at least a basal insulin, the isoelectric point pI of which is between 5.8 and 8.5; and a dextran substituted by radicals carrying carboxylate charges and hydrophobic radicals. Single-dose formulations at a pH of between 7 and 7.8 includes a basal insulin whose isoelectric point is between 5.8 and 8.5 and a prandial insulin.
    Type: Application
    Filed: August 9, 2012
    Publication date: March 14, 2013
    Applicant: ADOCIA
    Inventors: Olivier SOULA, Gérard SOULA, Jeff TONNAR
  • Patent number: 8389661
    Abstract: The invention relates to an amphiphilic-BMP polymer complex which is physically and chemically stable and soluble in water, characterized in that: the amphiphilic polymers comprise a hydrophilic polysaccharide skeleton functionalized with hydrophobic substituents and hydrophilic groups the BMP is selected from the group of therapeutically active BMPs (Bone morphogenetic Proteins), the polymer/BMP mass ratio is lower than or equal to 700. The invention also relates to the process for preparing the amphiphilic-BMP polymer complex in an aqueous medium and in the absence of organic solvents likely to denature the protein. The invention also relates to therapeutic compositions of an amphiphilic-BMP polymer complex according to the invention.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: March 5, 2013
    Assignee: ADOCIA
    Inventors: Gerard Soula, Olivier Soula, Remi Soula
  • Patent number: 8367640
    Abstract: The invention relates to a complex consisted of a polysaccharide and an HBP, said polysaccharide being consisted from glycoside bonds of (1,6) and/or (1,4) and/or (1,3) and/or (1,2) type and functionalized with at least one salifiable or salified tryptophan derivative. The invention also relates to a pharmaceutical composition comprising a complex according to the invention and to the use of a polysaccharide consisted of glycoside bonds of (1,6) and/or (1,4) and/or (1,3) and/or (1,2) type and functionalized with at least one salifiable or salified tryptophan derivative, for the preparation of a pharmaceutical formulation of stable HBPs.
    Type: Grant
    Filed: September 28, 2009
    Date of Patent: February 5, 2013
    Assignee: Adocia
    Inventors: Olivier Soula, Remi Soula, Martin Gaudier, Gerard Soula
  • Publication number: 20120309680
    Abstract: The invention relates to an oligodextran, chosen from dextrans whose average degree of polymerization is less than 10, modified by at least one substituent of general formula I: —R1-[[AA]-[R2]n]m??formula I It also relates to a pharmaceutical composition characterized in that it comprises an oligosaccharide according to the invention and an active ingredient is chosen from the group consisting of proteins, glycoproteins, peptides and non-peptide therapeutic molecules.
    Type: Application
    Filed: May 10, 2012
    Publication date: December 6, 2012
    Applicant: ADOCIA
    Inventors: Richard CHARVET, Remi SOULA, Olivier SOULA
  • Publication number: 20120295833
    Abstract: An anionic polysaccharide comprising carboxylic acid functional groups of formula I: in which: the polysaccharide may be either, synthetic or modified, i represents the degree of functionalization of the hydroxyls, j represents the degree of functionalization of the hydroxyls, L and Q represent an optionally branched and/or unsaturated chain comprising from 1 to 15 carbons, F is a functional group chosen from the group consisting of the carbamate functional group, the carbonyl being bonded to the Q radical, the ester functional group, the carbonyl being bonded to the Q radical, the amide functional group, the carbonyl being bonded to the Q radical, and the carboxylate functional group, and Grp is chosen from the group consisting of a mono- or divalent cation and of a chain comprising from 4 to 50 carbons.
    Type: Application
    Filed: May 10, 2012
    Publication date: November 22, 2012
    Applicant: ADOCIA
    Inventors: Richard CHARVET, Guilhem MORA, Rémi SOULA
  • Patent number: 8241620
    Abstract: Physically and chemically stable, water-soluble, amphiphilic polymer-PDGF complex, characterized in that the amphiphilic polymers include a hydrophilic polymeric backbone functionalized with hydrophobic substituents and hydrophilic groups.
    Type: Grant
    Filed: May 23, 2011
    Date of Patent: August 14, 2012
    Assignee: Adocia
    Inventors: Latifa Dahri-Correia, Jose Correia, Guy Dubreucq, David Duracher, Remi Soula, Olivier Soula, Gerard Soula
  • Publication number: 20120094902
    Abstract: A complex between an insulin and a polysaccharide comprising carboxyl functional groups is described, the polysaccharide being chosen from polysaccharides functionalized with at least one phenylalanine derivative, noted Phe, the phenylalanine derivative being chosen from phenylalanine and its alkali metal cation salts, phenylalaninol, phenylalaninamide and ethylbenzylamine or from phenylalanine esters, and the insulin being either a human insulin or an insulin analog. A pharmaceutical composition including at least one complex, especially in the form of an injectable solution, is also described.
    Type: Application
    Filed: November 2, 2011
    Publication date: April 19, 2012
    Applicant: ADOCIA
    Inventors: Olivier Soula, Rémi Soula, Gerard Soula
  • Publication number: 20120041079
    Abstract: Dextran of the following general formula I: is described, wherein R represents a chain containing from 1 to 15 carbon atoms and having at least one acid functional group prior to attachment to AA, the chain optionally being branched and/or unsaturated and containing one or more heteroatoms, such as O, N or/and S, F represents an ester, a carbamate or an ether, AA represents a hydrophobic amino acid radical, L or D, derived from a coupling between an amine of an amino acid and at least one acid functional group of R; the amino acid, prior to attachment to R, being selected from the group consisting of tryptophan, phenylalanine, leucine, isoleucine, alanine and valine, and alcohol, amide or decarboxylated derivatives thereof, and alkaline cation salts thereof, i represents the molar fraction of substituent F—R-[AA]n per glycosidic unit and is from 0.1 to 2, n represents the molar fraction of R groups substituted by AA and is from 0.
    Type: Application
    Filed: September 30, 2011
    Publication date: February 16, 2012
    Applicant: ADOCIA
    Inventors: Gerard SOULA, Olivier Soula, Remi Soula, Richard Charvet
  • Publication number: 20110301086
    Abstract: Physically and chemically stable, water-soluble, amphiphilic polymer-PDGF complex, characterized in that the amphiphilic polymers include a hydrophilic polymeric backbone functionalized with hydrophobic substituents and hydrophilic groups.
    Type: Application
    Filed: May 23, 2011
    Publication date: December 8, 2011
    Applicant: ADOCIA
    Inventors: Latifa Dahri-Correia, Jose Correia, Guy Dubreucq, David Duracher, Remi Soula, Olivier Soula, Gerard Soula
  • Publication number: 20110195913
    Abstract: Anionic polysaccharide derivatives partially functionalized by at least two vicinal hydrophobic groups, the hydrophobic groups, which are identical or different, being carried by an at least trivalent radical or spacer, a method of synthesis of the functionalized polysaccharides, and pharmaceutical compositions having one of the polysaccharides and at least one active principle are provided.
    Type: Application
    Filed: February 9, 2011
    Publication date: August 11, 2011
    Applicant: ADOCIA
    Inventors: Richard CHARVET, Remi SOULA, Olivier SOULA
  • Publication number: 20110178011
    Abstract: A complex of a polysaccharide and recombinant human BMP-2 and BMP-7, soluble at physiological pH, wherein the polysaccharide/BMP mass ratio is less than 15, the polysaccharide being selected from the group of polysaccharides having carboxyl functional groups, at least one of which is substituted with at least one hydrophobic radical.
    Type: Application
    Filed: November 19, 2010
    Publication date: July 21, 2011
    Applicant: ADOCIA
    Inventors: Remi SOULA, Olivier SOULA, Gerard SOULA, Richard CHARVET, David DURACHER