Patents Assigned to Adolor Corporation
  • Kappa agonist compounds and pharmaceutical formulations thereof
    Patent number: 6750216
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formula IIIB have the structure: wherein R1, R2, R, Ar and n are as described in the specification.
    Type: Grant
    Filed: May 15, 2002
    Date of Patent: June 15, 2004
    Assignee: Adolor Corporation
    Inventors: Virendra Kumar, Deqi Guo, Michael Anthony Marella, Alan L. Maycock
  • Delta agonist analgesics
    Patent number: 6630462
    Abstract: Methods and pharmaceutical compositions for the treatment of pain, preferably with lowered risk of induction of seizure in a patient.
    Type: Grant
    Filed: November 16, 2001
    Date of Patent: October 7, 2003
    Assignee: Adolor Corporation
    Inventors: Robert DeHaven, Erin Gauntner, Patrick Little, Wei Y. Zhang
  • Peripherally active anti-hyperalgesic opiates
    Patent number: 6573282
    Abstract: Compositions and methods using the compositions for treatment of peripheral hyperalgesia are provided. The compositions contain an anti-hyperalgesia effective amount of one or more compounds that directly or indirectly interact with peripheral opiate receptors, but that do not, upon topical or local administration, elicit substantial central nervous system effects. The anti-diarrheal compound 4-(p-chlorophenyl)-4-hydroxy-N-N-dimethyl-&agr;,&agr;-diphenyl-1-piperidinebutyramide hydrochloride is preferred for use in the compositions and methods.
    Type: Grant
    Filed: August 16, 1999
    Date of Patent: June 3, 2003
    Assignees: Adolor Corporation, The Regents of the University of California
    Inventors: Tony L. Yaksh, Alan L. Maycock
  • Novel methods for the treatment and prevention of ileus
    Publication number: 20020188005
    Abstract: Novel methods for the treatment and/or prevention of ileus. The methods may comprise administering to a patient an effective amount of a peripheral mu opioid antagonist compound. Preferred compounds for use in the methods include piperidine-N-alkylcarboxylates, quaternary morphinans, opium alkaloid derivatives and quaternary benzomorphans. The methods are particularly suitable for treating and/or preventing postsurgical ileus and postpartum ileus.
    Type: Application
    Filed: June 13, 2002
    Publication date: December 12, 2002
    Applicant: Adolor Corporation
    Inventors: John J. Farrar, Peter J. Schied, William K. Schmidt, Randall L. Carpenter
  • Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith
    Patent number: 6492351
    Abstract: The compounds of formulae IIA, the structure: wherein R1, R2, and X4, X5, n are as described in the specification.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: December 10, 2002
    Assignee: Adolor Corporation
    Inventors: Wei Yuan Zhang, Alan L. Maycock, Michael Anthony Marella, Virendra Kumar, Forrest Gaul, Deqi Guo
  • Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith
    Patent number: 6486165
    Abstract: Method for the prevention or treatment of pruritus with anti-pruritic compounds is provided.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: November 26, 2002
    Assignee: Adolor Corporation
    Inventors: Wei Yuan Zhang, Alan L. Maycock, Michael Anthony Marella, Virendra Kumar, Forrest Gaul, Deqi Guo
  • Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith
    Patent number: 6476063
    Abstract: Method for the prevention or treatment of pruritus with anti-pruritic compounds is provided. The compounds of formulae I, II, IIA, III, IIIA, IV and IVA have the structure: wherein R1, R2, R3, R4; and X, X4, X5, X7, X9; Y, Z and n are as described in the specification.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: November 5, 2002
    Assignee: Adolor Corporation
    Inventors: Wei Yuan Zhang, Alan L. Maycock, Anthony Michael Marella, Virendra Kumar, Forrest Gaul, Deqi Guo
  • Methods for the treatment and prevention of ileus
    Patent number: 6469030
    Abstract: Methods for the treatment and/or prevention of ileus are disclosed. The methods comprise administering to a patient an effective amount of a peripheral mu opioid antagonist compound. Preferred compounds for use in the methods include piperidine-N-alkylcarboxylates.
    Type: Grant
    Filed: November 29, 2000
    Date of Patent: October 22, 2002
    Assignee: Adolor Corporation
    Inventors: John J. Farrar, Peter J. Schied, William K. Schmidt, Randall L. Carpenter
  • Methods and compositions involving opioids and antagonists thereof
    Patent number: 6451806
    Abstract: Novel methods and compositions comprising opioids and opioid antagonists. In preferred embodiments, the methods and compositions comprise opioids and peripheral mu opioid antagonist compounds. The methods and compositions are particularly suitable for treating and/or preventing side effects associated with opioids including, for example, constipation, vomiting and/or nausea.
    Type: Grant
    Filed: November 29, 2000
    Date of Patent: September 17, 2002
    Assignee: Adolor Corporation
    Inventor: John J. Farrar
  • Kappa agonist compounds and pharmaceutical formulations thereof
    Patent number: 6391910
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formulae I, II, IIA, III, IIIA, IV and IVA have the structure: wherein R1, R2, R3, R4; and X, X4, X5, X7, X9; Y, Z and n are as described in the specification.
    Type: Grant
    Filed: January 6, 2000
    Date of Patent: May 21, 2002
    Assignee: Adolor Corporation
    Inventors: Wei Yuan Zhang, Alan L. Maycock, Michael Anthony Marella, Virendra Kumar, Forrest Gaul, An-Chih Chang, Deqi Guo
  • Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith
    Publication number: 20020042399
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and 5 method of using them as analgesics and pruritic agents are provided.
    Type: Application
    Filed: January 26, 2001
    Publication date: April 11, 2002
    Applicant: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang
  • Kappa agonist compounds and pharmaceutical formulations thereof
    Patent number: 6303611
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formula having the structure: wherein R1, R2, and X Y, Z, Ar and n are as described in the specification.
    Type: Grant
    Filed: September 9, 1998
    Date of Patent: October 16, 2001
    Assignee: Adolor Corporation
    Inventors: Wei Yuan Zhang, Alan L. Maycock, Michael Anthony Marella, Virendra Kumar, Forrest Gaul, An-Chih Chang, Deqi Guo
  • Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
    Patent number: 6239154
    Abstract: Method for the prevention or treatment of pruritis by administering to a patient an antipruritic compound, or pharmaceutically acceptable salt thereof, of the class arylacetamide, which is exemplified by compounds of the formulae I, II, IIA, III, IV and IVA having the structures: and in which R1-4, X, X4, X5, X7, X9, Y and Z are as described in the specification.
    Type: Grant
    Filed: August 11, 1999
    Date of Patent: May 29, 2001
    Assignee: Adolor Corporation
    Inventors: Wei Yuan Zhang, Alan L. Maycock, Michael Anthony Marella, Virendra Kumar, Forrest Gaul, Deqi Guo
  • Methods for treating inflammatory conditions
    Patent number: 6190691
    Abstract: The present invention provides a number of screening methods for evaluating compounds capable of suppressing cytokine production either in vitro or in vivo. The methods generally involve stimulating the production of a cytokine in a cell, exposing a portion of the cells to a putative cytokine modulating agent and determining subsequent levels of cytokine production in the cells. Additionally, the present invention provides certain compounds identified by this method.
    Type: Grant
    Filed: June 15, 1998
    Date of Patent: February 20, 2001
    Assignee: Adolor Corporation
    Inventor: Vivien H. W. Mak
  • Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith
    Patent number: 6180623
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and methods of using them as analgesics and anti-pruritic agents are provided. The compounds of formula IV have the structure: wherein X9; R1, R2, R3, R4; and n are as described in the specification.
    Type: Grant
    Filed: November 8, 1999
    Date of Patent: January 30, 2001
    Assignee: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang
  • Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
    Patent number: 6057323
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided.The compound of formula I, having the structure: ##STR1## wherein R.sub.1, R.sub.2 ;X; and ArY, Z and n are as described in the specification.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: May 2, 2000
    Assignee: Adolor Corporation
    Inventors: Wei Yuan Zhang, Alan L. Maycock, Michael Anthony Marella, Virendra Kumar, Forrest Gaul, An-Chih Chang, Deqi Guo
  • Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritis therewith
    Patent number: 6054445
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compound of formulae IIA, having the structure: ##STR1## wherein R.sub.1, R.sub.2 ;X.sub.4, X.sub.5 ; andAr and n are as described in the specification.
    Type: Grant
    Filed: May 7, 1999
    Date of Patent: April 25, 2000
    Assignee: Adolor Corporation
    Inventors: Wei Yuan Zhang, Alan L. Maycock, Michael Anthony Marella, Virendra Kumar, Forrest Gaul, An-Chih Chang, Deqi Guo
  • Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
    Patent number: 6048860
    Abstract: Anti-pruritic pharmaceutical formulations containing kappa agonist compounds and methods of prevention or treatment of pruritus in a mammal with the anti-pruritic formulations.
    Type: Grant
    Filed: October 4, 1999
    Date of Patent: April 11, 2000
    Assignee: Adolor Corporation
    Inventors: John J. Farrar, An-Chih Chang, Virendra Kumar, Wei Yuan Zhang, Alan Cowan
  • Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith
    Patent number: 6028063
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided.The compounds of formula III having the structure: ##STR1## wherein Ar and X.sup.7 ;R.sub.1 and R.sub.2 ; andn are as described in the specification.
    Type: Grant
    Filed: May 7, 1999
    Date of Patent: February 22, 2000
    Assignee: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang
  • Kappa agonist compounds and pharmaceutical formulations thereof
    Patent number: RE38133
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formulae I, II, III and IV have the structure: wherein: X, X4, X5, X7, X9; R1, R2, R3, R4; and Y, Z and n are as described in the specification.
    Type: Grant
    Filed: February 4, 2002
    Date of Patent: June 3, 2003
    Assignee: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang