Abstract: A device for use in equalizing the pressure inside a vial during the addition or removal of fluid comprising a one piece sterilizable device for use in equalizing the pressure inside a vial during the addition or removal of fluid which comprises a cannula having a sharpened beveled lower end for puncturing the septum of a vial, a blunt upper end covered with a septum that can be punctured by the needle of a hypodermic syringe, and an enlarged annular portion below the blunt upper end limiting entry of the device into the vial, said enlarged annular portion having an air channel leading from the inside of the cannula through the enlarged annular portion to the outside of the cannula said air channel being provided at its outer end with means for one-way air flow.
Abstract: It has been found that stereospecific R(-)-4-demethoxy-7-deoxydaunomycinone can be synthesized from the known compound 4-demethoxy-7,9-dideoxydaunomycinone. R(-)-4-Demethoxy-7-deoxy-daunomycinone is an intermediate in the synthesis of (+)-4-demethoxydaunomycinone, the aglycone of the nonnaturally occurring and antitumor active (-)7(S)9(S)-4-demethoxydaunorubicin.
Abstract: A synthesis of 5,12-dihydroxy-1,3,4-trihydro-2,6,11-tetracenetrione and its derivatives from leucoquinizarin or a derivative of leucoquinizarin. The tetracenetriones are well-known intermediates in the synthesis of compounds related to doxorubicin.
Abstract: A method for decreasing urinary calcium content which comprises orally administering to a person whose urine contains insoluble calcium containing precipitates or has a propensity for forming calcium containing precipitates, an effective amount of an agent selected from water-soluble vinylbenzenesulfonic acid polymers and the nontoxic pharmaceutically acceptable salts thereof.
Abstract: It has been found that fungal diseases can be effectively treated systemically by oral administration of tolciclate or tolnaftate. The drugs will generally be administered in divided daily doses in the form of tablets, capsules, syrups or suspensions.
Abstract: It has been found that indoprofen can be used in increased safety at its effective anti-inflammatory dose in humans and that the activity of indoprofen is greatly prolonged by microencapsulating microparticles of indoprofen in a solid protective coating of a cellulose ether such as ethylcellulose.
Abstract: The calcium salts of the solid cyclic copolymers of divinyl ether and maleic anhydride, soluble in water, have been found to be as effective in treating tumors and viruses as the prior art alkali metal salts (e.g., the sodium salt) but much less toxic. These copolymers are characterized by containing divinyl ether and maleic anhydride in a mole ratio of about 1:2, having a molecular weight of from about 2000 to about 100,000 and from about 5% to about 70% of its carboxylic acid groups converted to calcium salts.