Patents Assigned to Adria Laboratories Inc.
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Patent number: 4831019Abstract: Antineoplastic pharmaceutical preparations and a method for treating neoplastic conditions using 4-demethoxy-N-trifluoroacetyldaunomycin and 4-demethoxy-N-trifluoroacetyldoxorubicin.Type: GrantFiled: May 22, 1985Date of Patent: May 16, 1989Assignee: Adria Laboratories, Inc.Inventors: Richard L. Wolgemuth, John P. Carter
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Patent number: 4590063Abstract: Compounds of the formula ##STR1## where R is a methyl, ethyl or propyl group and n is 1 or 2 and their nontoxic salts are useful as anticonvulsants.Type: GrantFiled: April 25, 1985Date of Patent: May 20, 1986Assignee: Adria Laboratories, Inc.Inventors: John P. Carter, Jr., Richard L. Wolgemuth
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Patent number: 4543101Abstract: A device for use in equalizing the pressure inside a vial during the addition or removal of fluid comprising a one piece sterilizable device for use in equalizing the pressure inside a vial during the addition or removal of fluid which comprises a cannula having a sharpened beveled lower end for puncturing the septum of a vial, a blunt upper end covered with a septum that can be punctured by the needle of a hypodermic syringe, and an enlarged annular portion below the blunt upper end limiting entry of the device into the vial, said enlarged annular portion having an air channel leading from the inside of the cannula through the enlarged annular portion to the outside of the cannula said air channel being provided at its outer end with means for one-way air flow.Type: GrantFiled: March 28, 1984Date of Patent: September 24, 1985Assignee: Adria Laboratories, Inc.Inventor: Robert C. Crouch
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Patent number: 4540814Abstract: Compounds of the formula ##STR1## where R is a methyl, ethyl or propyl group and n is 1 or 2 and their nontoxic salts are useful as anticonvulsants.Type: GrantFiled: June 24, 1983Date of Patent: September 10, 1985Assignee: Adria Laboratories, Inc.Inventors: John P. Carter, Jr., Richard L. Wolgemuth
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Patent number: 4489206Abstract: It has been found that stereospecific R(-)-4-demethoxy-7-deoxydaunomycinone can be synthesized from the known compound 4-demethoxy-7,9-dideoxydaunomycinone. R(-)-4-Demethoxy-7-deoxy-daunomycinone is an intermediate in the synthesis of (+)-4-demethoxydaunomycinone, the aglycone of the nonnaturally occurring and antitumor active (-)7(S)9(S)-4-demethoxydaunorubicin.Type: GrantFiled: May 13, 1983Date of Patent: December 18, 1984Assignee: Adria Laboratories, Inc.Inventors: Michael P. Cava, Domingo Dominguez
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Patent number: 4470977Abstract: Benzamide derivatives useful as antiemetic or antipsychotic agents are discussed. In the preferred embodiments, administration of the compounds is not accompanied by mammary hypertrophy.Type: GrantFiled: September 1, 1982Date of Patent: September 11, 1984Assignee: Adria Laboratories, Inc.Inventor: James H. Short
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Patent number: 4471052Abstract: Chemically simplified versions of intermediates on the identified biosynthetic pathway to daunomycin are bioconverted to active analogues of naturally occurring antibiotics.Type: GrantFiled: January 18, 1982Date of Patent: September 11, 1984Assignee: Adria Laboratories, Inc.Inventors: Lester A. Mitscher, Daniel Lednicer
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Patent number: 4405522Abstract: A synthesis of 5,12-dihydroxy-1,3,4-trihydro-2,6,11-tetracenetrione and its derivatives from leucoquinizarin or a derivative of leucoquinizarin. The tetracenetriones are well-known intermediates in the synthesis of compounds related to doxorubicin.Type: GrantFiled: January 18, 1982Date of Patent: September 20, 1983Assignee: Adria Laboratories Inc.Inventor: Lester A. Mitscher
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Patent number: 4395392Abstract: A method for decreasing urinary calcium content which comprises orally administering to a person whose urine contains insoluble calcium containing precipitates or has a propensity for forming calcium containing precipitates, an effective amount of an agent selected from water-soluble vinylbenzenesulfonic acid polymers and the nontoxic pharmaceutically acceptable salts thereof.Type: GrantFiled: June 29, 1981Date of Patent: July 26, 1983Assignee: Adria Laboratories Inc.Inventor: Richard L. Wolgemuth
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Patent number: 4348407Abstract: It has been found that fungal diseases can be effectively treated systemically by oral administration of tolciclate or tolnaftate. The drugs will generally be administered in divided daily doses in the form of tablets, capsules, syrups or suspensions.Type: GrantFiled: April 29, 1981Date of Patent: September 7, 1982Assignee: Adria Laboratories, Inc.Inventors: Anthony R. Imondi, Irving Shemano
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Patent number: 4316884Abstract: It has been found that indoprofen can be used in increased safety at its effective anti-inflammatory dose in humans and that the activity of indoprofen is greatly prolonged by microencapsulating microparticles of indoprofen in a solid protective coating of a cellulose ether such as ethylcellulose.Type: GrantFiled: June 19, 1980Date of Patent: February 23, 1982Assignee: Adria Laboratories, Inc.Inventors: Abu S. Alam, Herman J. Eichel
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Patent number: 4223109Abstract: The calcium salts of the solid cyclic copolymers of divinyl ether and maleic anhydride, soluble in water, have been found to be as effective in treating tumors and viruses as the prior art alkali metal salts (e.g., the sodium salt) but much less toxic. These copolymers are characterized by containing divinyl ether and maleic anhydride in a mole ratio of about 1:2, having a molecular weight of from about 2000 to about 100,000 and from about 5% to about 70% of its carboxylic acid groups converted to calcium salts.Type: GrantFiled: February 22, 1979Date of Patent: September 16, 1980Assignee: Adria Laboratories Inc.Inventor: Richard L. Wolgemuth