Abstract: A cooling tank installation (10) for a liquid cooling of a charging station for electrically powered motor vehicles includes at least one reservoir (12, 14) for receiving an environmentally hazardous cooling medium. The reservoir (12, 14) is inserted in a retention vessel (16) for retaining a quantity of leakage from the reservoir (12, 14), and a receiving volume for receiving the entire liquid volume of the reservoir (12, 14) is formed between the reservoir (12, 14) and the retention vessel (16). The retention vessel (16) is inserted in an outer vessel (20) that provides support with respect to earth loads. An absorption body (24) is provided in the outer vessel (20) between the retention vessel (16) and the outer vessel (20) in the direction of gravity for absorbing moisture, and a moisture sensor detects moisture of the absorption body (24).

Abstract: A method of producing synergistic and enhanced efficacy in treating a disease in a subject includes providing an antibody, the antibody being a classic antibody or a modified biologic molecule that blocks a first target in the subject; providing a drug, the drug being a small molecule agent that blocks the first target or a second target in the subject; connecting the antibody and the drug with a linker to form an Antibody-Drug Synergism (ADS) compound; and treating the disease with the ADS compound. The linker is hydrolyzed in the subject over a certain time so that both the antibody and the drug exert their functions simultaneously, and the ADS compound confers better efficacy than either the antibody or the drug alone due to a synergism of the ADS compound.

Abstract: An automated sand dump system for oil and gas wells is provided that uses sensed parameters to determine and effective sand level within a sand trap. When the control system determines that the effective sand level reaches a predetermined level, an automated dump sequence is executed.

Abstract: A composition for use in the treatment of ocular hyperemia includes an anti-angiogenic agent and an ? adrenergic receptor agonist. A method for treating ocular hyperemia for a patient includes inhibiting a plurality of kinase receptors of the patient with an MKI; and activating ? adrenergic receptor of the patient with an agonist of the receptor.

Abstract: The invention relates to a mobile electric energy supply device, comprising at least one energy supply connector for drawing energy from the energy supply device, a ground grounding device adapted to cooperate with a ground of the installation site of the energy supply device to provide grounding for the energy supply device, and a touch safety monitoring device adapted to monitor at least one touch point disposed on or electrically connected to the energy supply device for touch safety.

Abstract: A topical ophthalmological composition includes a muscarinic receptor antagonist as an active pharmaceutical ingredient; and medium chain triglycerides (MCTs) or light liquid paraffin oil as liquid vehicle. The topical ophthalmological composition treats an ocular disease.

Abstract: A charging post (1) includes a charging cable (2) for connection to a mobile energy storage system. The charging cable (2) is guided out of the housing (3) of the charging post (1) via at least one cable outlet (5) and ends with a charging plug (4). The housing (3) has a support (10) for a cable holder (20), which support is held about an upright pivot axis (11). The cable outlet (5) is provided on the front housing wall (19), on an outer wall (13, 14) or on the rear wall (15) of the housing (3). The cable outlet (5) is positioned with an outlet opening (23) facing the plane (33) of the roof section (8) of the charging post (1), wherein the cable outlet (5) is designed as a support (10) for the cable holder (20).

Abstract: Compositions and methods of using nintedanib for treating indications with abnormal neovascularization in the front part of the eye are disclosed.

Abstract: A drilling system includes a choke valve system in fluid communication with a wellbore via a fluid return line. The choke valve system is configured to receive a return fluid from the wellbore. The choke valve system includes a choke valve through which the return fluid flows and a valve position sensor configured to determine a position of the choke valve. The drilling system further includes a controller in signal communication with the valve position sensor. The controller is programmed to determine a flow rate of the return fluid through the fluid return line based on the determined position of the choke valve. The controller is further programmed to adjust the position of the choke valve in response to the determined flow rate of the return fluid.

Abstract: A multipurpose latch assembly (MPLA) for installation above the bore of a blowout preventer includes an annular sidewall extending between a top flange and a bottom flange and having an interior bore surface defining an interior bore. A plurality of latching slots extend through the sidewall and a latching dog is slidably positioned in each latching slot. Actuators are connected to the latching dogs to extend and retract them through the latching slots. A tool having an external slot can be inserted into the bore of the MPLA and selectively engaged by the latching dogs to secure the tool in the bore of above the blowout preventer.

Abstract: A system for automated testing of a high-pressure pump comprises a choke valve, actuator and actuator drive for operating the choke in response to receiving control signals. A system control unit includes a processor unit, system memory, I/O interface, human-machine interface, and display device. A pressure sensor is connected to the pump outlet line for sensing and reporting outlet pressure to the control unit. The control unit can execute a test phase by causing the pump to run at a test speed and causing the actuator to change the restriction value of the choke until a predetermined pressure is sensed in the outlet line and reported to the control unit. The control unit can cause the actuator to maintain the predetermined pressure for a predetermined period of time. The control unit can cause the display device to show a result or print a report of one or more test phases.

Abstract: An integrated control system (ICS) for a well drilling platform is provided, which well drilling platform has a plurality of control systems and devices. The ICS includes an ICS controller is in communication with a master control. The ICS controller includes a memory device coupled to a processor. Instructions executed by the processor cause the ICS controller to: communicate with each of the control systems to determine a status of each of the control systems; cause the master control display to display status information for at least one of the control systems; in response to an operator input perform a well drilling platform function, the function requiring a coordinated state between a first control system and at least a second control system, configure the first control system and the second control system into a coordinated state.

Abstract: A wear sleeve for use with a rotating control device (RCD) includes a wear insert and a retainer flange. The wear insert is formed in a tube shape with an outer profile to match an inner profile of a downstream neck of the RCD to be inserted into the downstream neck. The retainer flange extending from an outer surface of the wear insert to couple with a neck flange at an end of the downstream neck of the RCD.

Abstract: A well drilling system is provided that includes a choke manifold and a controller. The choke manifold includes at least one choke valve. The choke valve is actuable between fully open and closed choke positions. The choke valve has a Cv value for each choke position. The controller is in communication with the choke valve and a non-transitory memory storing instructions. The instructions relate Cv values to choke positions for the choke valve. The instructions when executed cause the controller to: a) determine a difference in pressure (?P); b) input or determine a density value; c) input or determine a Q value; d) determine a first Cv value using the ?P, the density value, and the Q value; and e) actuate the choke valve to a first choke position associated with the first Cv value.

Abstract: A multipurpose latch assembly (MPLA) for installation above the bore of a blowout preventer includes an annular sidewall extending between a top flange and a bottom flange and having an interior bore surface defining an interior bore. A plurality of latching slots extend through the sidewall and a latching dog is slidably positioned in each latching slot. Actuators are connected to the latching dogs to extend and retract them through the latching slots. A tool having an external slot can be inserted into the bore of the MPLA and selectively engaged by the latching dogs to secure the tool in the bore of above the blowout preventer.

Abstract: A rotating control device is disclosed for the use of oil, gas or geothermal wells. While providing for sealing with or without rotation of the drill pipe, the device consists of a housing with guide rails attached beneath the two part dual actuated clamp that can be locked in place by remote controlled retention pins. The design has a novel adapter design enabling a common RCD bearing assembly to be installed in a variety of different housing sizes.

Abstract: A control system and method for a well drilling platform having a plurality well platform systems is provided. The control system includes at least one remote communication unit (RCU), and a controller. The controller is in communication with the well platform systems, and has at least one processor, and a memory device that is coupled to the processor and that stores the instructions. When executed by the processor, the instructions cause the controller to communicate with the well platform systems to receive information from one or more well platform systems and to send system control commands to the one or more well platform systems. The controller and the at least one RCU are configured to electronically communicate with one another information relating to at least one of the well platform systems.

Abstract: A choke valve is provided having a body, a seat, and a gate. The body has an internal chamber, an inlet flow passage, and an outlet flow passage. The seat has a seat orifice with an area, the seat positioned at an end of the outlet flow passage contiguous with the internal chamber. The gate has a gate shaft and a gate body affixed to one end of the gate shaft. The gate is linearly translatable within the body between a fully open position and a fully closed position, wherein in the fully closed position the gate body is engaged with the seat orifice. In the fully open position a choke minimum passage area is defined between the gate body and the seat orifice, and the choke minimum passage area is at least 30% of the seat orifice area.

Abstract: Compositions and methods of using nintedanib for treating indications with abnormal neovascularization in the front part of the eye are disclosed.

Abstract: A drilling system includes a choke valve system in fluid communication with a wellbore via a fluid return line. The choke valve system is configured to receive a return fluid from the wellbore. The choke valve system includes a choke valve through which the return fluid flows and a valve position sensor configured to determine a position of the choke valve. The drilling system further includes a controller in signal communication with the valve position sensor. The controller is programmed to determine a flow rate of the return fluid through the fluid return line based on the determined position of the choke valve. The controller is further programmed to adjust the position of the choke valve in response to the determined flow rate of the return fluid.