Abstract: Compositions and methods of using nintedanib for treating indications with abnormal neovascularization in the front part of the eye are disclosed.

Abstract: A drilling system includes a choke valve system in fluid communication with a wellbore via a fluid return line. The choke valve system is configured to receive a return fluid from the wellbore. The choke valve system includes a choke valve through which the return fluid flows and a valve position sensor configured to determine a position of the choke valve. The drilling system further includes a controller in signal communication with the valve position sensor. The controller is programmed to determine a flow rate of the return fluid through the fluid return line based on the determined position of the choke valve. The controller is further programmed to adjust the position of the choke valve in response to the determined flow rate of the return fluid.

Abstract: A multipurpose latch assembly (MPLA) for installation above the bore of a blowout preventer includes an annular sidewall extending between a top flange and a bottom flange and having an interior bore surface defining an interior bore. A plurality of latching slots extend through the sidewall and a latching dog is slidably positioned in each latching slot. Actuators are connected to the latching dogs to extend and retract them through the latching slots. A tool having an external slot can be inserted into the bore of the MPLA and selectively engaged by the latching dogs to secure the tool in the bore of above the blowout preventer.

Abstract: A system for automated testing of a high-pressure pump comprises a choke valve, actuator and actuator drive for operating the choke in response to receiving control signals. A system control unit includes a processor unit, system memory, I/O interface, human-machine interface, and display device. A pressure sensor is connected to the pump outlet line for sensing and reporting outlet pressure to the control unit. The control unit can execute a test phase by causing the pump to run at a test speed and causing the actuator to change the restriction value of the choke until a predetermined pressure is sensed in the outlet line and reported to the control unit. The control unit can cause the actuator to maintain the predetermined pressure for a predetermined period of time. The control unit can cause the display device to show a result or print a report of one or more test phases.

Abstract: An integrated control system (ICS) for a well drilling platform is provided, which well drilling platform has a plurality of control systems and devices. The ICS includes an ICS controller is in communication with a master control. The ICS controller includes a memory device coupled to a processor. Instructions executed by the processor cause the ICS controller to: communicate with each of the control systems to determine a status of each of the control systems; cause the master control display to display status information for at least one of the control systems; in response to an operator input perform a well drilling platform function, the function requiring a coordinated state between a first control system and at least a second control system, configure the first control system and the second control system into a coordinated state.

Abstract: A wear sleeve for use with a rotating control device (RCD) includes a wear insert and a retainer flange. The wear insert is formed in a tube shape with an outer profile to match an inner profile of a downstream neck of the RCD to be inserted into the downstream neck. The retainer flange extending from an outer surface of the wear insert to couple with a neck flange at an end of the downstream neck of the RCD.

Abstract: A well drilling system is provided that includes a choke manifold and a controller. The choke manifold includes at least one choke valve. The choke valve is actuable between fully open and closed choke positions. The choke valve has a Cv value for each choke position. The controller is in communication with the choke valve and a non-transitory memory storing instructions. The instructions relate Cv values to choke positions for the choke valve. The instructions when executed cause the controller to: a) determine a difference in pressure (?P); b) input or determine a density value; c) input or determine a Q value; d) determine a first Cv value using the ?P, the density value, and the Q value; and e) actuate the choke valve to a first choke position associated with the first Cv value.

Abstract: A multipurpose latch assembly (MPLA) for installation above the bore of a blowout preventer includes an annular sidewall extending between a top flange and a bottom flange and having an interior bore surface defining an interior bore. A plurality of latching slots extend through the sidewall and a latching dog is slidably positioned in each latching slot. Actuators are connected to the latching dogs to extend and retract them through the latching slots. A tool having an external slot can be inserted into the bore of the MPLA and selectively engaged by the latching dogs to secure the tool in the bore of above the blowout preventer.

Abstract: A rotating control device is disclosed for the use of oil, gas or geothermal wells. While providing for sealing with or without rotation of the drill pipe, the device consists of a housing with guide rails attached beneath the two part dual actuated clamp that can be locked in place by remote controlled retention pins. The design has a novel adapter design enabling a common RCD bearing assembly to be installed in a variety of different housing sizes.

Abstract: A control system and method for a well drilling platform having a plurality well platform systems is provided. The control system includes at least one remote communication unit (RCU), and a controller. The controller is in communication with the well platform systems, and has at least one processor, and a memory device that is coupled to the processor and that stores the instructions. When executed by the processor, the instructions cause the controller to communicate with the well platform systems to receive information from one or more well platform systems and to send system control commands to the one or more well platform systems. The controller and the at least one RCU are configured to electronically communicate with one another information relating to at least one of the well platform systems.

Abstract: A choke valve is provided having a body, a seat, and a gate. The body has an internal chamber, an inlet flow passage, and an outlet flow passage. The seat has a seat orifice with an area, the seat positioned at an end of the outlet flow passage contiguous with the internal chamber. The gate has a gate shaft and a gate body affixed to one end of the gate shaft. The gate is linearly translatable within the body between a fully open position and a fully closed position, wherein in the fully closed position the gate body is engaged with the seat orifice. In the fully open position a choke minimum passage area is defined between the gate body and the seat orifice, and the choke minimum passage area is at least 30% of the seat orifice area.

Abstract: Compositions and methods of using nintedanib for treating indications with abnormal neovascularization in the front part of the eye are disclosed.

Abstract: A drilling system includes a choke valve system in fluid communication with a wellbore via a fluid return line. The choke valve system is configured to receive a return fluid from the wellbore. The choke valve system includes a choke valve through which the return fluid flows and a valve position sensor configured to determine a position of the choke valve. The drilling system further includes a controller in signal communication with the valve position sensor. The controller is programmed to determine a flow rate of the return fluid through the fluid return line based on the determined position of the choke valve. The controller is further programmed to adjust the position of the choke valve in response to the determined flow rate of the return fluid.

Abstract: A self activating vent cap configured to be operably coupled to a needleless connector and automatically shifted relative to the needleless connector from the first, storage position to a second, activated position upon rotation of the vent cap relative to the needleless connector. The self activating vent cap including a threaded portion, an activation portion and a biasing mechanism, wherein shifting of the activation portion to the second, activated position is selectively precluded by the interference of at least one ridge of the threaded portion with a ledge of the activation portion.

Abstract: A topical ophthalmological composition includes a muscarinic receptor antagonist as an active pharmaceutical ingredient; and a semifluorinated alkane, as a liquid vehicle. The topical ophthalmological composition treats an ocular disease.

Abstract: A composition for use in the treatment of rosacea includes a multi-kinase inhibitor that inhibits both a Vascular Endothelial Growth Factor Receptor and a Fibroblast Growth Factor Receptor. A method for treating rosacea for a patient includes inhibiting a Vascular Endothelial Growth Factor Receptor of the patient; and inhibiting a Fibroblast Growth Factor Receptor of the patient.

Abstract: A method for treating a meibomian gland dysfunction of an affected eye includes administering to the affected eye of a subject in need of such treatment a steroidal-androgen-free composition containing a therapeutically effective amount of a cyclic polysaccharide. A steroidal-androgen-free composition includes a cyclic polysaccharide as an active pharmaceutical ingredient for treating a meibomian gland dysfunction of an affected eye.

Abstract: The invention relates to an energy store comprising an arrangement of battery cells (70, 80, 90) in an installation housing (2), wherein groups (I, II, III) of battery cells (70, 80, 90) follow one another in the direction of the longitudinal axis (10) of the installation housing (2). Within each group (I, II, III) of battery cells (70, 80, 90), a flow path (50, 51, 52) for cooling air is formed, which flow path connects a feed air opening (35, 36, 46) for a cooling air flow (5, 6) to a cooling air outlet (20, 21, 23). In order to achieve effective cooling, first feed air openings (35) and a first cooling air outlet (20) are associated with a first flow path (50) in a first group (I) of battery cells (70) and second feed air openings (36) and a second cooling air outlet (21) are associated with a second flow path (51) in a second group (II) of battery cells (80).

Abstract: An integrated control system (ICS) for a well drilling platform is provided, which well drilling platform has a plurality of control systems and devices. The ICS includes an ICS controller is in communication with a master control. The ICS controller includes a memory device coupled to a processor. Instructions executed by the processor cause the ICS controller to: communicate with each of the control systems to determine a status of each of the control systems; cause the master control display to display status information for at least one of the control systems; in response to an operator input perform a well drilling platform function, the function requiring a coordinated state between a first control system and at least a second control system, configure the first control system and the second control system into a coordinated state.

Abstract: A velocity sensor and housing therefore, the velocity sensor provides a measurement of the velocity in a sewer manhole or chamber. The velocity sensor includes an ultrasonic transducer that emits a signal to measure the liquid below and may use an additional transducer or it is used by itself to detect the signal reflected from the surface. A parabolic reflector is designed and arranged to direct the emitted ultrasonic signal from the transducer to the surface with a linear beam while minimizing the beam spread. The return echo may either be measured directly or with the same transducer that was used to transmit the ultrasonic signal.