Patents Assigned to Advance Biofactures of Curacao
  • Reduction of adipose tissue
    Patent number: 6958150
    Abstract: The amount of adipose tissue, including lipomas, at selected locations in the body is reduced by introducing collagenase or collagenase plus another proteinase into the tissue.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: October 25, 2005
    Assignee: Advance Biofactures of Curacao, N.V.
    Inventors: Edwin H. Wegman, Burton Bronsther, Erwin T. Jacob
  • Reduction of adipose tissue
    Publication number: 20030129178
    Abstract: The amount of adipose tissue, including lipomas, at selected locations in the body is reduced by introducing collagenase or collagenase plus another proteinase into the tissue.
    Type: Application
    Filed: June 14, 2002
    Publication date: July 10, 2003
    Applicant: Advance Biofactures of Curacao, N.V.
    Inventors: Edwin H. Wegman, Burton Bronsther, Erwin T. Jacob
  • Amelioration of dupuytren's disease
    Patent number: 6086872
    Abstract: The cords of Dupuytren's disease are injected with collagenase, the hand is immediately immobilized and maintained immobile for several hours. The cord becomes relaxed or ruptured, relieving the hand contracture of the disease.
    Type: Grant
    Filed: March 27, 1997
    Date of Patent: July 11, 2000
    Assignee: Advance BioFactures of Curacao, NV
    Inventor: Thomas L. Wegman
  • Amelioration of peyronie's disease
    Patent number: 6022539
    Abstract: A method of treating an individual suffering from Peyronie's disease. Collagenase is injected into a fibrous Peyronie's plaque in the penis of the individual suffering from the disease. The penis immediately after injection, is immobilized and maintained immobile for several hours. The collagenase is in a pharmaceutically acceptable carrier in a concentration of about 20,000 to about 40,000 ABC units per ml.
    Type: Grant
    Filed: June 3, 1999
    Date of Patent: February 8, 2000
    Assignee: Advance Biofactures of Curacao
    Inventor: Thomas L. Wegman
  • Treatment of Dupuytren's disease with collagenase
    Patent number: 5589171
    Abstract: Dupuytren's disease is treated by applying collagenase to the affected palmar fascia.
    Type: Grant
    Filed: August 22, 1994
    Date of Patent: December 31, 1996
    Assignee: Advance Biofactures of Curacao
    Inventor: Thomas L. Wegman
  • High dosage topical forms of collagenase
    Patent number: 5514370
    Abstract: This invention provides pharmaceutical compositions for topical application containing high concentrations of the enzyme collagenase in non-aqueous excipients. The invention also provides a particular excipient, dextran, which is especially useful for admixture with collagenase and which can also be used to advantage with other pharmaceutically active materials.
    Type: Grant
    Filed: November 7, 1994
    Date of Patent: May 7, 1996
    Assignee: Advance Biofactures of Curacao, N.V.
    Inventors: Harold Stern, David Yee
  • High dosage topical forms of collagenase
    Patent number: 5422103
    Abstract: This invention provides pharmaceutical compositions for topical application containing high concentrations of the enzyme collagenase in non-aqueous excipients. The invention also provides a particular excipient, dextran, which is especially useful for admixture with collagenase and which can also be used to advantage with othr pharmaceutically active materials.
    Type: Grant
    Filed: November 24, 1993
    Date of Patent: June 6, 1995
    Assignee: Advance Biofactures of Curacao, N.V.
    Inventors: Harold Stern, David Yee
  • High dosage topical forms of collagenase
    Patent number: 5393792
    Abstract: High concentrations of collagenase as active ingredient in non-aqueous topical pharmaceutical formulations.
    Type: Grant
    Filed: October 29, 1992
    Date of Patent: February 28, 1995
    Assignee: Advance Biofactures of Curacao, N.V.
    Inventors: Harold Stern, David Yee
  • Method of enhancing the regeneration of injured nerves and adhesive pharmaceutical formulation therefor
    Patent number: 5279825
    Abstract: The regeneration of injured nerves is enhanced by supplying collagenase to the zone of injury of the nerve. Growth of nerve sprouts over the zone of injury is aided by the presence of effective amounts of collagenase during the regeneration process. If the nerve has been severed, collagenase is supplied to the ends of the proximal and distal stumps. A nerve graft may be interposed between the stumps. Natural fibrin has been used as glue to join nerve stumps, and collagenase is effective when used in admixture with fibrin.
    Type: Grant
    Filed: September 8, 1992
    Date of Patent: January 18, 1994
    Assignee: Advance Biofactures of Curacao, N.V.
    Inventor: Peter Wehling
  • Method of enhancing the regeneration of injured nerves and adhesive pharamaceutical formulation therefor
    Patent number: 5173295
    Abstract: The regeneration of injured nerves is enhanced by supplying collagenase to the zone of injury of the nerve. Growth of nerve sprouts over the zone of injury is aided by the presence of effective amounts of collagenase during the regeneration process. If the nerve has been severed, collagenase is supplied to the ends of the proximal and distal stumps. A nerve graft may be interposed between the stumps. Natural fibrin has been used as glue to join nerve stumps, and collagenase is effective when used in admixture with fibrin.
    Type: Grant
    Filed: October 5, 1990
    Date of Patent: December 22, 1992
    Assignee: Advance Biofactures of Curacao, N.V.
    Inventor: Peter Wehling