Patents Assigned to Advanced Bioconcept (1994) Ltd.
  • Patent number: 6680367
    Abstract: Light emitting compounds of the formula where R1 is a light-emitting moiety, R2 is a CRF-related peptide and fragment, derivative or analog thereof and L is a linker moiety, which may be present or absent. The peptide is linked at a first amino acid position to (C—X) which, in turn, is selected from the group including C═O, C═S, CH(OH), C═C═O, C═NH, CH2, CH(OR), CH(NR), CH(R), CR3R4, and C(OR3)OR4 where R, R3, and R4 are alkyl moieties or substituted alkyl moieties. Optionally the compound may include a linker moiety between the peptide and the C—X binding group. Preferably, the compound exhibits substantial biological activity in the presence of receptors having affinities for CRF-related peptides.
    Type: Grant
    Filed: July 19, 1999
    Date of Patent: January 20, 2004
    Assignee: Advanced Bioconcept Company
    Inventors: Clarissa Desjardins, Jacek Slon-Usakiewicz, Katherine J. Bonter
  • Patent number: 6677430
    Abstract: Light emitting compounds of the formula: where R1 is a light-emitting moiety and R2 is a motilin peptide and fragment, derivative or analog thereof The peptide is linked at a first amino acid position to (C—X) which, in turn, is selected from the group including C═O, C═S, CH(OH), C═C═O, C═NH, CH2, CH(OR), CH(NR), CH(R), CR3R4, and C(OR3)OR4 where R, R3, and R4 are alkyl moieties or substituted alkyl moieties. Optionally the compound may include a linker moiety between the peptide and the C—X binding group. Preferably, the compound exhibits substantial biological activity in the presence of receptors having affinities for motilin peptides.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: January 13, 2004
    Assignee: Advanced Bioconcept Company
    Inventors: Clarissa Desjardins, Jacek Slon-Usakiewicz, Katherine J. Bonter
  • Patent number: 6054557
    Abstract: The invention provides biologically active compounds of the formula: ##STR1## where R.sub.1 is a light-emitting moiety and R.sub.7 is a peptide of between 2 and 200 amino acids. X is selected from the group including .dbd.O, .dbd.S, --OH, .dbd.C.tbd.O, .dbd.NH, --H, --OR, --NR, --R, --R.sub.3 R.sub.4, wherein each R, R.sub.4 and R.sub.3, independently, is H or a C1-C6 branched or unbranched, substituted or unsubstituted, alkyl. The compounds are both biologically active and optically detectable. The peptide is chemically attached to the light-emitting moiety at an amino acid position which is not involved in binding to the peptide's receptor. In this way, the peptide's affinity for its receptor is not significantly decreased, and the compound retains high biological activity and can be easily detected using standard optical means.
    Type: Grant
    Filed: July 10, 1996
    Date of Patent: April 25, 2000
    Assignee: Advanced Bioconcept (1994) Ltd.
    Inventors: Marie-Pierre Faure, Jean-Pierre Vincent, Georges Gaudriault, Alain Beaudet, Clarissa Desjardins
  • Patent number: 5894078
    Abstract: A transgenic mouse whose genome comprises a DNA sequence encoding the carboxy-terminal 100 amino acids of the human .beta.-amyloid precursor protein C-100 APP) inserted into exon I of the neurofilament gene such that all or part of exon I has been deleted is disclosed. Expression of the nucleic acid sequence is under the control of neurofilament L-gene regulatory region. The mouse as a result of the expression exhibits a brain morphology of an increased amyloid accumulation, and increase in reactive astrocytes, an increased microglial activation and a decreased number of neurons, and also exhibits spatial memory impairment.
    Type: Grant
    Filed: February 26, 1996
    Date of Patent: April 13, 1999
    Assignee: Advanced Bioconcept, Inc.
    Inventors: Josephine Nalbantoglu, Jean-Pierre Julien, Matthew Shapiro
  • Patent number: 5824772
    Abstract: Light-emitting compounds of the formula: ##STR1## where R.sub.1 is a light-emitting moiety and R.sub.2 is a somatostatin-based peptide featuring a first amino acid sequence -Phe-Phe-Trp-Lys-Thr- or (SEQ ID NO:1) or -Phe-Phe-D-Trp-Lys-Thr-. The peptide is linked at a first amino acid position to (C-X), and the light-emitting compound exhibits substantial biological activity in the presence of a receptor having affinity for somatostatin-based peptides.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 20, 1998
    Assignee: Advanced Bioconcept, Inc.
    Inventors: Jean-Pierre Vincent, Georges Gaudriault, Alain Beaudet
  • Patent number: 5693679
    Abstract: Light-emitting compounds of the formula: ##STR1## where R.sub.1 is a light-emitting moiety and R.sub.2 is a somatostatin-based peptide featuring a first amino acid sequence --Phe--Phe--Trp--Lys--Thr-- (SEQ ID NO:1) or --Phe--Phe--D--Trp--Lys--Thr--. The peptide is linked at a first amino acid position to (C--X), and the light-emitting compound exhibits substantial biological activity in the presence of a receptor having affinity for somatostatin-based peptides.
    Type: Grant
    Filed: April 4, 1995
    Date of Patent: December 2, 1997
    Assignee: Advanced Bioconcept, Inc.
    Inventors: Jean-Pierre Vincent, Georges Gaudriault, Alain Beaudet