Patents Assigned to Advanced Bioconcept (1994) Ltd.
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Patent number: 6680367Abstract: Light emitting compounds of the formula where R1 is a light-emitting moiety, R2 is a CRF-related peptide and fragment, derivative or analog thereof and L is a linker moiety, which may be present or absent. The peptide is linked at a first amino acid position to (C—X) which, in turn, is selected from the group including C═O, C═S, CH(OH), C═C═O, C═NH, CH2, CH(OR), CH(NR), CH(R), CR3R4, and C(OR3)OR4 where R, R3, and R4 are alkyl moieties or substituted alkyl moieties. Optionally the compound may include a linker moiety between the peptide and the C—X binding group. Preferably, the compound exhibits substantial biological activity in the presence of receptors having affinities for CRF-related peptides.Type: GrantFiled: July 19, 1999Date of Patent: January 20, 2004Assignee: Advanced Bioconcept CompanyInventors: Clarissa Desjardins, Jacek Slon-Usakiewicz, Katherine J. Bonter
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Patent number: 6677430Abstract: Light emitting compounds of the formula: where R1 is a light-emitting moiety and R2 is a motilin peptide and fragment, derivative or analog thereof The peptide is linked at a first amino acid position to (C—X) which, in turn, is selected from the group including C═O, C═S, CH(OH), C═C═O, C═NH, CH2, CH(OR), CH(NR), CH(R), CR3R4, and C(OR3)OR4 where R, R3, and R4 are alkyl moieties or substituted alkyl moieties. Optionally the compound may include a linker moiety between the peptide and the C—X binding group. Preferably, the compound exhibits substantial biological activity in the presence of receptors having affinities for motilin peptides.Type: GrantFiled: March 31, 2000Date of Patent: January 13, 2004Assignee: Advanced Bioconcept CompanyInventors: Clarissa Desjardins, Jacek Slon-Usakiewicz, Katherine J. Bonter
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Patent number: 6054557Abstract: The invention provides biologically active compounds of the formula: ##STR1## where R.sub.1 is a light-emitting moiety and R.sub.7 is a peptide of between 2 and 200 amino acids. X is selected from the group including .dbd.O, .dbd.S, --OH, .dbd.C.tbd.O, .dbd.NH, --H, --OR, --NR, --R, --R.sub.3 R.sub.4, wherein each R, R.sub.4 and R.sub.3, independently, is H or a C1-C6 branched or unbranched, substituted or unsubstituted, alkyl. The compounds are both biologically active and optically detectable. The peptide is chemically attached to the light-emitting moiety at an amino acid position which is not involved in binding to the peptide's receptor. In this way, the peptide's affinity for its receptor is not significantly decreased, and the compound retains high biological activity and can be easily detected using standard optical means.Type: GrantFiled: July 10, 1996Date of Patent: April 25, 2000Assignee: Advanced Bioconcept (1994) Ltd.Inventors: Marie-Pierre Faure, Jean-Pierre Vincent, Georges Gaudriault, Alain Beaudet, Clarissa Desjardins
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Patent number: 5894078Abstract: A transgenic mouse whose genome comprises a DNA sequence encoding the carboxy-terminal 100 amino acids of the human .beta.-amyloid precursor protein C-100 APP) inserted into exon I of the neurofilament gene such that all or part of exon I has been deleted is disclosed. Expression of the nucleic acid sequence is under the control of neurofilament L-gene regulatory region. The mouse as a result of the expression exhibits a brain morphology of an increased amyloid accumulation, and increase in reactive astrocytes, an increased microglial activation and a decreased number of neurons, and also exhibits spatial memory impairment.Type: GrantFiled: February 26, 1996Date of Patent: April 13, 1999Assignee: Advanced Bioconcept, Inc.Inventors: Josephine Nalbantoglu, Jean-Pierre Julien, Matthew Shapiro
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Patent number: 5824772Abstract: Light-emitting compounds of the formula: ##STR1## where R.sub.1 is a light-emitting moiety and R.sub.2 is a somatostatin-based peptide featuring a first amino acid sequence -Phe-Phe-Trp-Lys-Thr- or (SEQ ID NO:1) or -Phe-Phe-D-Trp-Lys-Thr-. The peptide is linked at a first amino acid position to (C-X), and the light-emitting compound exhibits substantial biological activity in the presence of a receptor having affinity for somatostatin-based peptides.Type: GrantFiled: June 7, 1995Date of Patent: October 20, 1998Assignee: Advanced Bioconcept, Inc.Inventors: Jean-Pierre Vincent, Georges Gaudriault, Alain Beaudet
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Patent number: 5693679Abstract: Light-emitting compounds of the formula: ##STR1## where R.sub.1 is a light-emitting moiety and R.sub.2 is a somatostatin-based peptide featuring a first amino acid sequence --Phe--Phe--Trp--Lys--Thr-- (SEQ ID NO:1) or --Phe--Phe--D--Trp--Lys--Thr--. The peptide is linked at a first amino acid position to (C--X), and the light-emitting compound exhibits substantial biological activity in the presence of a receptor having affinity for somatostatin-based peptides.Type: GrantFiled: April 4, 1995Date of Patent: December 2, 1997Assignee: Advanced Bioconcept, Inc.Inventors: Jean-Pierre Vincent, Georges Gaudriault, Alain Beaudet