Patents Assigned to Advanced Cardiovascular Systems, Inc.
  • Patent number: 10390979
    Abstract: Methods and systems of fabricating a polymeric stent are disclosed herein.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: August 27, 2019
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: David C. Gale, Bin Huang, Anthony J. Abbate, Timothy A. Limon, Klaus Kleine
  • Patent number: 10028851
    Abstract: An implantable medical device, such as a stent, with a coating region for controlling erosion of the substrate region is disclosed.
    Type: Grant
    Filed: June 30, 2005
    Date of Patent: July 24, 2018
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Steve Dugan, David C. Gale
  • Patent number: 9993583
    Abstract: Method are disclosed for local and systemic administration HDL, recombinant HDL or HDLm for the prevention, treatment, or amelioration of a vascular disorder, disease or occlusion such as restenosis or vulnerable plaque.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: June 12, 2018
    Assignee: ADVANCED CARDIOVASCULAR SYSTEMS, INC.
    Inventor: Ni Ding
  • Patent number: 9950144
    Abstract: An apparatus for delivering devices. The apparatus comprises a catheter with an elongated shaft having a first lumen and a second lumen extending therethrough. The apparatus further comprises a distal section with a lumen in communication with a port in a distal end of the catheter and with the first lumen and the second lumen. The first lumen is configured for a first device and the second lumen is configured for a second device to be disposed therein. The apparatus further comprises a proximal adapter coupled to the elongated shaft with a first port in communication with the first lumen and a second port in communication with the second lumen.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: April 24, 2018
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Mina Chow, Dwight A. Ambat, Jinhua Chen, Eugene T. Michal
  • Patent number: 9561351
    Abstract: An implantable medical device is disclosed having a helical construct including a set of spiral coils for local in vivo application of a therapeutic substance in a biological lumen. The helical construct is configured to apply less than 0.75 Bar of pressure to the biological lumen wall. The helical construct can have at least two sets of spiral coils having opposing helical directions. The device can be used for the treatment of vascular disorders such as restenosis and vulnerable plaque.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: February 7, 2017
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Klaus Kleine, David C. Gale, Fozan El-Nounou, Syed F. A. Hossainy, Florian Ludwig
  • Patent number: 9561309
    Abstract: A medical device comprising a coating thereon comprising a biocompatible polymer and heparin is provided herein. Heparin is coupled with the biocompatible polymer via a spacer having a grouping that renders a binding site of the heparin molecule accessible by a binding protein. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
    Type: Grant
    Filed: May 27, 2004
    Date of Patent: February 7, 2017
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Thierry Glauser, Eugene Michal, Charles Claude, Stephen D. Pacetti
  • Patent number: 9456983
    Abstract: A composition that includes a bioactive agent-containing polymeric nanoparticle and a polymeric non-spherical microparticle, and methods of using such a composition to treat a vascular disease are disclosed.
    Type: Grant
    Filed: December 8, 2006
    Date of Patent: October 4, 2016
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed Faiyaz Ahmed Hossainy, Florian Niklas Ludwig, Stephen D. Pacetti
  • Patent number: 9445885
    Abstract: The bending flexibility profile of a stent closely matches the flexibilities of the stent delivery system on either side of the stent. In one embodiment, a stent has a longitudinal axis and at least one link attaching each ring to an adjacent ring. The links closest to the stent end rings have the greatest bending flexibility and the links closest to the center of the stent have the least bending flexibility.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: September 20, 2016
    Assignee: Advanced Cardiovascular Systems Inc.
    Inventor: Karim Said Osman
  • Patent number: 9345814
    Abstract: A polymer of hydrophobic monomers and hydrophilic monomers is provided. It is also provided a polymer blend that contains the polymer and another biocompatible polymer. The polymer or polymer blend and optionally a biobeneficial material and/or a bioactive agent can form a coating on an implantable device such as a drug delivery stent. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: May 24, 2016
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Ni Ding
  • Patent number: 9283099
    Abstract: Medical assemblies with a releasable connection and methods of constructing such medical assemblies are disclosed. The medical assemblies generally comprise a stent, a catheter assembly having catheter body a balloon, and a releasable connection between the stent and the catheter assembly that releases the stent from the catheter assembly in response to enlargement of the balloon or when the balloon has been enlarged to an expanded configuration.
    Type: Grant
    Filed: August 25, 2004
    Date of Patent: March 15, 2016
    Assignee: ADVANCED CARDIOVASCULAR SYSTEMS, INC.
    Inventors: David C. Gale, Klaus Kleine, Anthony J. Abbate, Svava Maria Atladottir, Bin Huang
  • Patent number: 9248034
    Abstract: Implantable medical devices for treating bodily disorders local and distally to a region of implantation are disclosed. The devices include a body structure including an active agent, erodable particles acting as a carrier of the active agent, and an erodable binder. The binder releasably binds the particles together such that after implantation the binder erodes to release the particles.
    Type: Grant
    Filed: August 23, 2005
    Date of Patent: February 2, 2016
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F. A. Hossainy, David C. Gale, Florian N. Ludwig
  • Patent number: 9192494
    Abstract: Radially expandable implantable medical devices, such as stents, with locking elements are disclosed.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: November 24, 2015
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Timothy A. Limon, David C. Gale, Bin Huang, Klaus Kleine
  • Patent number: 9188558
    Abstract: A method and system of monitoring environmental exposure of stents using radiofrequency identification is disclosed.
    Type: Grant
    Filed: June 8, 2010
    Date of Patent: November 17, 2015
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Abigail Freeman, David C. Gale, Bin Huang, Daniel Castro
  • Patent number: 9180227
    Abstract: Methods are disclosed for controlling the morphology and the release-rate of active agent from coating layers for medical devices comprising a polymer matrix and one or more active agents. The methods comprise fixing the morphology or phase distribution of the active agent prior to removing solvent from the coating composition. The coating layers can be used for controlled the delivery of an active agent or a combination of active agents.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: November 10, 2015
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Florian N. Ludwig, Syed F. A. Hossainy, Srinivasan Sridharan, Carol Lee
  • Patent number: 9173982
    Abstract: A polymer coating for medical devices based on a polyolefin derivative. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The polymers include homo-, co-, and terpolymers having at least one olefin-derived unit and at least one unit derived from vinyl alcohol, allyl alcohol and derivatives thereof.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: November 3, 2015
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Stephen Dirk Pacetti
  • Patent number: 9175162
    Abstract: A coating for implantable medical devices and a method for fabricating thereof are disclosed. The coating includes a mixture of a hydrophobic polymer and a polymeric hydrophilic additive, wherein the hydrophobic polymer and the hydrophilic additive form a physically entangled or interpenetrating system.
    Type: Grant
    Filed: September 19, 2007
    Date of Patent: November 3, 2015
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Stephen D. Pacetti, Yiwen Tang
  • Patent number: 9149602
    Abstract: An apparatus for delivering devices. The apparatus comprises a catheter with an elongated shaft having a first lumen and a second lumen extending therethrough. The apparatus further comprises a distal section with a lumen in communication with a port in a distal end of the catheter and with the first lumen and the second lumen. The first lumen is configured for a first device and the second lumen is configured for a second device to be disposed therein. The apparatus further comprises a proximal adapter coupled to the elongated shaft with a first port in communication with the first lumen and a second port in communication with the second lumen.
    Type: Grant
    Filed: April 22, 2005
    Date of Patent: October 6, 2015
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Mina Chow, Dwight A. Ambat, Jin Cheng, Eugene Michal
  • Patent number: 9138513
    Abstract: Method are disclosed for local and systemic administration HDL, recombinant HDL or HDLm for the prevention, treatment, or amelioration of a vascular disorder, disease or occlusion such as restenosis or vulnerable plaque.
    Type: Grant
    Filed: May 6, 2011
    Date of Patent: September 22, 2015
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Ni Ding
  • Patent number: 9114198
    Abstract: Coatings for an implantable medical device and a method of fabricating the coatings are disclosed. The coatings comprise a fluorinated polymer and a biologically beneficial polymer, an example of which includes poly(ethylene-glycol)-block poly(butylene terephthalate)-block poly(ethylene-glycol). A biologically active agent can be additionally conjugated to the biologically beneficial polymer.
    Type: Grant
    Filed: November 19, 2003
    Date of Patent: August 25, 2015
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F. A. Hossainy, Yiwen Tang
  • Patent number: 9101689
    Abstract: Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: August 11, 2015
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F. A. Hossainy, Stephen D. Pacetti, Keith E. Fong, Vinayak Bhat, Deborra Sanders Millare, Judy A. Guruwaiya, Daryush Mirzaee, Evgenia Mandrusov