Patents Assigned to Advanced Cardiovascular Systems, Inc.
  • Freeze-Thaw Method For Modifying Stent Coating
    Publication number: 20120231049
    Abstract: Methods are disclosed for controlling the morphology and the release-rate of active agent from a coating layer for medical devices comprising a polymer matrix and one or more active agents. The methods comprise exposing a wet or dry coating to a freeze-thaw cycle. The coating layer can be used for controlled delivery of an active agent or a combination of active agents.
    Type: Application
    Filed: May 25, 2012
    Publication date: September 13, 2012
    Applicant: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F.A. Hossainy, Gordon Stewart, Benjamyn Serna, Lothar W. Kleiner
  • Embolic filtering devices
    Patent number: 8262689
    Abstract: A self-expanding basket for use in conjunction with an embolic filtering device has a proximal set of struts which are connected to a distal set of struts by a bending region which provides enhanced bending characteristics to the basket. The bending region can be formed by intermediate links which are extremely flexible and bendable to allow the basket to be delivered through tortuous anatomy. The intermediate links are extremely flexible and create a mechanical hinge-like connection between the proximal and distal strut assemblies. The basket thus is capable of substantial bending when being delivered through the patient's vasculature and will bend and conform to the patient's anatomy once positioned for filtering purposes. The intermediate links can also lengthen, when needed, when positioned in a curved vessel in the patient's vasculature, when needed.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: September 11, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Gary Schneiderman, Anuja H. Patel, Paul F. Muller, William J. Boyle, Thomas A. Hassing, Thomas H. Majcher
  • Stent mandrel fixture and method for reducing coating defects
    Patent number: 8263169
    Abstract: A stent mandrel fixture for supporting a stent during the application of a coating substance is provided.
    Type: Grant
    Filed: October 6, 2008
    Date of Patent: September 11, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Fuh-Wei Tang, Syed F. A. Hossainy, Dorie Happ, Ty T. Hu
  • Functionalized chemically inert polymers for coatings
    Patent number: 8263107
    Abstract: Provided herein are methods for functionalizing a polymer for forming a coating and coatings and devices formed thereof or for functionalizing a coating or device surface including an polymer.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: September 11, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Stephen Dirk Pacetti, Syed Faiyaz Ahmed Hossainy
  • Apparatus to prevent reperfusion injury
    Patent number: 8262612
    Abstract: Embodiments of a method and apparatus to prevent reperfusion injury. In one embodiment, blood flow proximal to a lesion is occluded. An infusion catheter is advanced to a region distal to the lesion and an anti-reperfusion injury drug is delivered. The lesion may then be treated with a dilating device to reintroduce blood flow to the region distal to the lesion.
    Type: Grant
    Filed: November 10, 2010
    Date of Patent: September 11, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Daniel L. Cox, Hongzhi Bai, Paul Consigny, Jessica G. Chiu
  • Methods for immobilizing anti-thrombogenic material onto a medical device or into a coating thereon
    Patent number: 8263170
    Abstract: The present invention is directed to a medical device having a polymerized base coat layer for the immobilization of an anti-thrombogenic material, such as heparin, thereon. The binding coat layer is comprised of various chemically functional groups which are stable and allow for the immobilization of the anti-thrombogenic material thereto. Methods for immobilizing the anti-thrombogenic material within the base coat layer posited on a surface of the medical device are also provided.
    Type: Grant
    Filed: January 6, 2010
    Date of Patent: September 11, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Eugene T. Michal, Ni Ding, Christopher Buchko
  • Intravascular stent with a plurality of first and second peaks
    Patent number: 8257426
    Abstract: The invention is directed to an expandable stent for implanting in a body lumen, such as a coronary artery, peripheral artery, or other body lumen. The invention provides for an intravascular stent having a plurality of cylindrical rings connected by undulating links. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen. The stent can be compressed or crimped onto a catheter to a very low profile since the peaks that are adjacent the curved portion of the undulating link are shorter than other peaks in the same cylindrical ring to prevent overlap yet still achieve a very low profile, tightly crimped stent onto a catheter.
    Type: Grant
    Filed: April 1, 2009
    Date of Patent: September 4, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Andreina P. Gomez, Diem Uyen Ta
  • Metal composite guide wire
    Patent number: 8257278
    Abstract: A guide wire for guiding a medical device within a patient is disclosed. The guide wire has a solid inner core made of high modulus material such as Conichrome® or a rhenium alloy, and an outer shell made of a flexible, kink resistant material such as a nickel-titanium alloy. Preferably, the modulus of elasticity of the inner core material is at least about 20 percent greater than that of the outer shell material. The outer shell is mechanically joined to the inner core through a drawing or cladding process. In various embodiments, the distal end of the guide wire can be tapered by grinding away the outer shell to expose the inner core. Because of its stiffness, it can be manually shaped by the physician or cardiologist.
    Type: Grant
    Filed: May 14, 2002
    Date of Patent: September 4, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Jonathan M. Howland, Wayne E. Cornish, Mark T. Richardson
  • METHOD OF FABRICATING AN IMPLANTABLE MEDICAL DEVICE WITH BIAXIALLY ORIENTED POLYMERS
    Publication number: 20120217672
    Abstract: Methods and systems for manufacturing an implantable medical device, such as a stent, from a tube with desirable mechanical properties, such as improved circumferential strength and rigidity, are described herein. Improved circumferential strength and rigidity may be obtained by inducing molecular orientation in materials for use in manufacturing an implantable medical device. Methods of inducing circumferential molecular orientation by inducing circumferential flow in a molten polymer are disclosed.
    Type: Application
    Filed: May 3, 2012
    Publication date: August 30, 2012
    Applicant: Advanced Cardiovascular Systems, Inc.
    Inventors: Bin Huang, Stephen Schaible, Richard Kaufman, Jim Kennedy, David C. Gale, Suresh Amin, John Guardiano
  • Freeze-thaw method for modifying stent coating
    Patent number: 8246973
    Abstract: Methods are disclosed for controlling the morphology and the release-rate of active agent from a coating layer for medical devices comprising a polymer matrix and one or more active agents. The methods comprise exposing a wet or dry coating to a freeze-thaw cycle. The coating layer can be used for controlled delivery of an active agent or a combination of active agents.
    Type: Grant
    Filed: June 21, 2006
    Date of Patent: August 21, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F. A. Hossainy, Gordon Stewart, Benjamyn Serna, Lothar W. Kleiner
  • Stent retention mold and method
    Patent number: 8240020
    Abstract: A stent retention mold includes two half-molds, each half-mold including a stent supporting surface, and a plurality of protrusions disposed on at least one of the stent supporting surfaces. A stent retention method includes retaining a stent to a balloon using a split mold that includes a stent supporting surface having a plurality of protrusions, so that a portion of the balloon extends through a gap of the stent into a space between two protrusions.
    Type: Grant
    Filed: June 30, 2006
    Date of Patent: August 14, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Darrin J. Kent, Boyd V. Knott, Jeremy L. Stigall, Kyle M. Krueger, Sean A. McNiven
  • Method of forming a stent pattern on a tube
    Patent number: 8241554
    Abstract: Methods of fabricating an implantable medical device from a tube or a sheet in an expanded or stretched state, respectively, are disclosed herein. The implantable medical device may be an endoprosthesis such as a stent. In one embodiment, the method may include radially expanding a tube about a cylindrical axis of the tube from a first diameter to a second diameter. The method may further include forming a pattern on at least a portion of the expanded tube. Additional embodiments may include forming a stent pattern on a stretched sheet from which a stent may be formed. In addition, a stent pattern may be formed on a tube that is formed from a stretched sheet.
    Type: Grant
    Filed: June 29, 2004
    Date of Patent: August 14, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Anthony J. Abbate, David C. Gale, Klaus Kleine, Svava Maria Atladottir
  • Stent coating method
    Patent number: 8236369
    Abstract: An apparatus and method for coating abluminal surface of a stent is described. A method for coating a stent can include stent mounting, stent movement, and droplet excitation. A method can include applying a coating to a stent, the applying including generating waves in a coating solution to eject droplets of the coating solution from a surface of the coating solution toward the stent, the generating performed by transducers submerged in the coating solution.
    Type: Grant
    Filed: July 20, 2010
    Date of Patent: August 7, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Yung Ming Chen
  • Coatings for drug delivery devices having gradient of hydration
    Patent number: 8231962
    Abstract: A coating for an implantable medical device is provided comprising a first layer including a first polymer and a second layer including a second polymer. The second layer is disposed over at least a portion of the first layer. The second polymer has a lower degree of hydration than the first polymer.
    Type: Grant
    Filed: January 18, 2008
    Date of Patent: July 31, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Stephen D. Pacetti, Syed F. A. Hossainy, Yiwen Tang, Andrew C. Tung, Thierry Glauser
  • Isocyanate coatings for implantable devices and a method of forming the same
    Patent number: 8211457
    Abstract: Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: July 3, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F. A. Hossainy, Stephen D. Pacetti, Keith E. Fong, Vinayak Bhat, Deborra Sanders Millare, Judy A. Guruwaiya, Daryush Mirzaee, Evgenia Mandrusov
  • Intravascular stent and method of use
    Patent number: 8211161
    Abstract: An expandable stent is implanted in a body lumen, such as a coronary artery, peripheral artery, or other body lumen for treating an area of vulnerable plaque. The invention provides for a an intravascular stent having a plurality of cylindrical rings connected by undulating links. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen. A central section is positioned between distal and proximal sections and is aligned with the area of vulnerable plaque to enhance growth of endothelial cells over the fibrous cap of the vulnerable plaque to reinforce the area and reduce the likelihood of rupture.
    Type: Grant
    Filed: December 19, 2006
    Date of Patent: July 3, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Timothy A. Limon
  • High amine content polymer coatings for implantable devices and a method of forming the same
    Patent number: 8206733
    Abstract: Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: June 26, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F. A. Hossainy, Stephen D. Pacetti, Keith E. Fong, Vinayak Bhat, Deborra Sanders Millare, Judy A. Guruwaiya, Daryush Mirzaee, Evgenia Mandrusov
  • INTRACORONARY DEVICE AND METHOD OF USE THEREOF
    Publication number: 20120157751
    Abstract: Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems.
    Type: Application
    Filed: February 21, 2012
    Publication date: June 21, 2012
    Applicant: ADVANCED CARDIOVASCULAR SYSTEMS INC.
    Inventors: Paul Consigny, Gabriel Asongwe, Mary Beth Michaels, Gene Michal, Evgenia Mandrusov, Jeong Lee, Florian Ludwig, John Eric Henckel, Joseph J. Sciacca, Ken Bueche, Richard Todd Thornton, Fidel Albert Urrabazo, Daniel Wiegand
  • Biocompatible coatings for stents
    Patent number: 8202530
    Abstract: A coating for a medical device, particularly for a stent, is described. The coating comprises a polymer and a biologically responsive compound. The coating can also contain a drug to provide enhanced therapeutic effect.
    Type: Grant
    Filed: November 28, 2005
    Date of Patent: June 19, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Syed F. A. Hossainy
  • NON-COMPLIANT MULTILAYERED BALLOON FOR A CATHETER
    Publication number: 20120145317
    Abstract: Method of making a multilayer balloon for a catheter having a nominal working diameter comprises forming a tube having at least a first layer and a second layer having a combined wall thickness. The first layer is made of a first polymer material having a first maximum blow-up-ratio and the second layer is made of a second polymer material having a second maximum blow-up-ratio greater than the first maximum blow-up-ratio. The second layer is an inner layer relative to the first layer. The method also comprises forming the multilayer balloon from the tube in a balloon mold having an inner diameter corresponding to the balloon's nominal working diameter. The at least first and second layers of the multilayer balloon define a compliance less than that of a single layer balloon made of the first polymer material with a wall thickness equal to the combined wall thickness.
    Type: Application
    Filed: February 15, 2012
    Publication date: June 14, 2012
    Applicant: Advanced Cardiovascular Systems, Inc.
    Inventor: Jonathan P. Durcan