Patents Assigned to Advanced Cell Technology
  • Patent number: 8753884
    Abstract: An improved method of producing differentiated progenitor cells comprising obtaining inner cell mass cells from a blastocyst and inducing differentiation of the inner cell mass cells to produce differentiated progenitor cells. The differentiated progenitor cells may be transfected such that there is an addition, deletion or alteration of a desired gene. The differentiated progenitor cells are useful in cell therapy and as a I source of cells for the production of tissues and organs for transplantation. Also provided is a method of producing a lineage-defective human embryonic stem cell.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: June 17, 2014
    Assignee: Advanced Cell Technology
    Inventors: Jose Cibelli, Michael D. West, Robert Lanza
  • Patent number: 8742200
    Abstract: This present invention provides novel methods for deriving embryonic stem cells and embryo-derived cells from an embryo without requiring destruction of the embryo. The invention further provides cells and cell lines derived without embryo destruction, and the use of the cells for therapeutic and research purposes. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e.g., in conjunction with reproductive therapies such as IVF.
    Type: Grant
    Filed: January 11, 2011
    Date of Patent: June 3, 2014
    Assignee: Advanced Cell Technology, Inc.
    Inventors: Young Gie Chung, Robert Lanza, Irina V. Klimanskaya
  • Publication number: 20140057348
    Abstract: The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.
    Type: Application
    Filed: October 29, 2013
    Publication date: February 27, 2014
    Applicant: ADVANCED CELL TECHNOLOGY, INC.
    Inventors: Michael D. West, Karen B. Chapman, Irina V. Klimanskaya
  • Patent number: 8642328
    Abstract: This present invention provides novel methods for deriving embryonic stem cells, those cells and cell lines, and the use of the cells for therapeutic and research purposes without the destruction of the embryo. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e.g., in conjunction with reproductive therapies such as IVF.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: February 4, 2014
    Assignee: Advanced Cell Technology, Inc.
    Inventors: Robert Lanza, Young Chung
  • Patent number: 8597944
    Abstract: The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: December 3, 2013
    Assignee: Advanced Cell Technology, Inc.
    Inventors: Michael D. West, Karen B. Chapman, Irina V. Klimanskaya
  • Publication number: 20130316452
    Abstract: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
    Type: Application
    Filed: April 8, 2013
    Publication date: November 28, 2013
    Applicant: Advanced Cell Technology, Inc.
    Inventor: Advanced Cell Technology, Inc.
  • Publication number: 20130316451
    Abstract: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
    Type: Application
    Filed: April 8, 2013
    Publication date: November 28, 2013
    Applicant: Advanced Cell Technology, Inc.
    Inventor: Advanced Cell Technology, Inc.
  • Publication number: 20130302288
    Abstract: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
    Type: Application
    Filed: April 18, 2013
    Publication date: November 14, 2013
    Applicant: Advanced Cell Technology, Inc.
    Inventor: Advanced Cell Technology, Inc.
  • Publication number: 20130302824
    Abstract: Methods are provided for detection of a target cell type within a cell population, and compositions are provided comprising cells and an indicator that indicates the number of cells of the target cell type in the cell population. Examples are provided in which these methods are used to detect human embryonic stem cells within a differentiated cell population with exquisite sensitivity. Differentiated cells produced from embryonic stem cells can be characterized by these methods before transplantation into a recipient, thereby providing further assurance of safety.
    Type: Application
    Filed: July 25, 2011
    Publication date: November 14, 2013
    Applicant: Advanced Cell Technology, Inc.
    Inventors: Irina Klimanskaya, Roger Gay
  • Publication number: 20130195806
    Abstract: This disclosure provides the first description of hESC-derived cells transplanted into human patients. Results are reported for one patient with each of Stargardt's Macular Dystrophy (SMD) and Dry Age-Related Macular Degeneration (AMD). Controlled hESC differentiation resulted in near-100% pure RPE populations. Immediately after surgery, hyperpigmentation was visible at the transplant site in both patients, with subsequent evidence the cells had attached and integrated into the native RPE layer. No signs of inflammation or hyperproliferation were observed. The hESC-derived RPE cells have shown no signs of rejection or tumorigenicity at the time of this report. Visual measurements suggest improvement in both patients.
    Type: Application
    Filed: November 14, 2012
    Publication date: August 1, 2013
    Applicant: ADVANCED CELL TECHNOLOGY, INC.
    Inventor: Advanced Cell Technology, Inc.
  • Publication number: 20130183272
    Abstract: The present invention generally relates to novel preparations of mesenchymal stromal cells (MSCs) derived from hemangioblasts, methods for obtaining such MSCs, and method sof treating a pathology using such MSCs. The methods of the present invention produce substantial numbers of MSCs having a potency-retaining youthful phenotype, which are useful in the treatment of pathologies.
    Type: Application
    Filed: November 30, 2012
    Publication date: July 18, 2013
    Applicant: ADVANCED CELL TECHNOLOGY, INC.
    Inventor: Advanced Cell Technology, Inc.
  • Publication number: 20130102073
    Abstract: Activated human embryos produced by therapeutic cloning can give rise to human totipotent and pluripotent stem cells from which autologous cells for transplantation therapy are derived. The present invention provides methods for producing activated human embryos that can be used to generate totipotent and pluripotent stem cells from which autologous cells and tissues suitable for transplantation can be derived. The ability to create autologous human embryos represents a critical step towards generating immune-compatible stem cells that can be used to overcome the problem of immune rejection in regenerative medicine. The activated human embryos produced by the present invention also provide model systems for identifying and analyzing the molecular mechanisms of epigenetic imprinting and the genetic regulation of embryogenesis and development.
    Type: Application
    Filed: October 16, 2012
    Publication date: April 25, 2013
    Applicant: ADVANCED CELL TECHNOLOGY, INC.
    Inventors: Jose Cibelli, Michael West, Keith Campbell
  • Publication number: 20120258451
    Abstract: Methods for laser microdissection isolation of viable cells are provided. Cells of a desired type may be isolated from a diverse population, optionally with detection and exclusion of undesired cells. Desired cells may be isolated from a population that arose from differentiation of pluripotent cells, preferably embryonic stem cells or induced pluripotent stem cells, and undifferentiated stem cells may be detected and excluded from selection including the isolation of RPE cells sleeted based on morphology (e.g., characteristic mottled appearance) from a population of ES cells. The cells isolated by these methods, including RPE cells, may be essentially free of undifferentiated cells and thus suitable for use in cell-based therapies.
    Type: Application
    Filed: April 6, 2012
    Publication date: October 11, 2012
    Applicant: Advanced Cell Technology, Inc.
    Inventor: Irina Vitaly KLIMANSKAYA
  • Patent number: 8273571
    Abstract: Methods for obtaining pluripotent (embryonic stem) cells from parthenogenetic embryos, especially primates, are provided. These cells are useful for producing differentiated cells, tissues and organs, especially human and non-human primate cells, tissues and organs.
    Type: Grant
    Filed: May 27, 2011
    Date of Patent: September 25, 2012
    Assignee: Advanced Cell Technology, Inc.
    Inventors: James M. Robl, Jose Cibelli, Amy Burnside
  • Patent number: 8268303
    Abstract: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: September 18, 2012
    Assignee: Advanced Cell Technology, Inc.
    Inventors: Irina V. Klimanskaya, Robert P. Lanza
  • Publication number: 20120027731
    Abstract: Methods of generating and expanding human hemangio-colony forming cells in vitro and methods of expanding and using such cells are disclosed. The methods permit the production of large numbers of hemangio-colony forming cells as well as derivative cells, such as hematopoietic and endothelial cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications.
    Type: Application
    Filed: July 26, 2011
    Publication date: February 2, 2012
    Applicant: ADVANCED CELL TECHNOLOGY
    Inventors: Robert Lanza, Shi-Jiang Lu
  • Publication number: 20110293580
    Abstract: Methods for obtaining pluripotent (embryonic stem) cells from parthenogenetic embryos, especially primates, are provided. These cells are useful for producing differentiated cells, tissues and organs, especially human and non-human primate cells, tissues and organs.
    Type: Application
    Filed: May 27, 2011
    Publication date: December 1, 2011
    Applicant: Advanced Cell Technology, Inc.
    Inventors: James M. ROBL, Jose Cibelli, Amy Burnside
  • Patent number: 8017393
    Abstract: Methods of generating and expanding human hemangio-colony forming cells in vitro and methods of expanding and using such cells are disclosed. The methods permit the production of large numbers of hemangio-colony forming cells as well as derivative cells, such as hematopoietic and endothelial cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications.
    Type: Grant
    Filed: April 13, 2007
    Date of Patent: September 13, 2011
    Assignee: Advanced Cell Technology
    Inventors: Robert Lanza, Shi-Jiang Lu
  • Patent number: 7951591
    Abstract: Methods for obtaining pluripotent (embryonic stem) cells from parthenogenetic embryos, especially primates, are provided. These cells are useful for producing differentiated cells, tissues and organs, especially human and non-human primate cells, tissues and organs.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: May 31, 2011
    Assignee: Advanced Cell Technology, Inc.
    Inventors: James M. Robl, Jose Cibelli, Amy Burnside
  • Publication number: 20110117062
    Abstract: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
    Type: Application
    Filed: August 17, 2010
    Publication date: May 19, 2011
    Applicant: Advanced Cell Technology, Inc.
    Inventors: Irina V. Klimanskaya, Robert Lanza