Patents Assigned to Advanced Cell Technology
  • Patent number: 8597944
    Abstract: The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: December 3, 2013
    Assignee: Advanced Cell Technology, Inc.
    Inventors: Michael D. West, Karen B. Chapman, Irina V. Klimanskaya
  • Publication number: 20130316452
    Abstract: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
    Type: Application
    Filed: April 8, 2013
    Publication date: November 28, 2013
    Applicant: Advanced Cell Technology, Inc.
    Inventor: Advanced Cell Technology, Inc.
  • Publication number: 20130316451
    Abstract: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
    Type: Application
    Filed: April 8, 2013
    Publication date: November 28, 2013
    Applicant: Advanced Cell Technology, Inc.
    Inventor: Advanced Cell Technology, Inc.
  • Publication number: 20130302824
    Abstract: Methods are provided for detection of a target cell type within a cell population, and compositions are provided comprising cells and an indicator that indicates the number of cells of the target cell type in the cell population. Examples are provided in which these methods are used to detect human embryonic stem cells within a differentiated cell population with exquisite sensitivity. Differentiated cells produced from embryonic stem cells can be characterized by these methods before transplantation into a recipient, thereby providing further assurance of safety.
    Type: Application
    Filed: July 25, 2011
    Publication date: November 14, 2013
    Applicant: Advanced Cell Technology, Inc.
    Inventors: Irina Klimanskaya, Roger Gay
  • Publication number: 20130302288
    Abstract: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
    Type: Application
    Filed: April 18, 2013
    Publication date: November 14, 2013
    Applicant: Advanced Cell Technology, Inc.
    Inventor: Advanced Cell Technology, Inc.
  • Publication number: 20120258451
    Abstract: Methods for laser microdissection isolation of viable cells are provided. Cells of a desired type may be isolated from a diverse population, optionally with detection and exclusion of undesired cells. Desired cells may be isolated from a population that arose from differentiation of pluripotent cells, preferably embryonic stem cells or induced pluripotent stem cells, and undifferentiated stem cells may be detected and excluded from selection including the isolation of RPE cells sleeted based on morphology (e.g., characteristic mottled appearance) from a population of ES cells. The cells isolated by these methods, including RPE cells, may be essentially free of undifferentiated cells and thus suitable for use in cell-based therapies.
    Type: Application
    Filed: April 6, 2012
    Publication date: October 11, 2012
    Applicant: Advanced Cell Technology, Inc.
    Inventor: Irina Vitaly KLIMANSKAYA
  • Patent number: 8273571
    Abstract: Methods for obtaining pluripotent (embryonic stem) cells from parthenogenetic embryos, especially primates, are provided. These cells are useful for producing differentiated cells, tissues and organs, especially human and non-human primate cells, tissues and organs.
    Type: Grant
    Filed: May 27, 2011
    Date of Patent: September 25, 2012
    Assignee: Advanced Cell Technology, Inc.
    Inventors: James M. Robl, Jose Cibelli, Amy Burnside
  • Patent number: 8268303
    Abstract: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: September 18, 2012
    Assignee: Advanced Cell Technology, Inc.
    Inventors: Irina V. Klimanskaya, Robert P. Lanza
  • Publication number: 20110293580
    Abstract: Methods for obtaining pluripotent (embryonic stem) cells from parthenogenetic embryos, especially primates, are provided. These cells are useful for producing differentiated cells, tissues and organs, especially human and non-human primate cells, tissues and organs.
    Type: Application
    Filed: May 27, 2011
    Publication date: December 1, 2011
    Applicant: Advanced Cell Technology, Inc.
    Inventors: James M. ROBL, Jose Cibelli, Amy Burnside
  • Patent number: 8017393
    Abstract: Methods of generating and expanding human hemangio-colony forming cells in vitro and methods of expanding and using such cells are disclosed. The methods permit the production of large numbers of hemangio-colony forming cells as well as derivative cells, such as hematopoietic and endothelial cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications.
    Type: Grant
    Filed: April 13, 2007
    Date of Patent: September 13, 2011
    Assignee: Advanced Cell Technology
    Inventors: Robert Lanza, Shi-Jiang Lu
  • Patent number: 7951591
    Abstract: Methods for obtaining pluripotent (embryonic stem) cells from parthenogenetic embryos, especially primates, are provided. These cells are useful for producing differentiated cells, tissues and organs, especially human and non-human primate cells, tissues and organs.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: May 31, 2011
    Assignee: Advanced Cell Technology, Inc.
    Inventors: James M. Robl, Jose Cibelli, Amy Burnside
  • Publication number: 20110117062
    Abstract: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
    Type: Application
    Filed: August 17, 2010
    Publication date: May 19, 2011
    Applicant: Advanced Cell Technology, Inc.
    Inventors: Irina V. Klimanskaya, Robert Lanza
  • Publication number: 20110117063
    Abstract: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
    Type: Application
    Filed: August 17, 2010
    Publication date: May 19, 2011
    Applicant: Advanced Cell Technology, Inc.
    Inventors: Irina V. Klimanskaya, Robert Lanza
  • Patent number: 7910369
    Abstract: The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.
    Type: Grant
    Filed: August 24, 2005
    Date of Patent: March 22, 2011
    Assignee: Advanced Cell Technology, Inc.
    Inventors: Michael D. West, Karen B. Chapman, Irina V. Klimanskaya
  • Patent number: 7893315
    Abstract: This present invention provides novel methods for deriving embryonic stem cells and embryo-derived cells from an embryo without requiring destruction of the embryo. The invention further provides cells and cell lines derived without embryo destruction, and the use of the cells for therapeutic and research purposes. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e.g., in conjunction with reproductive therapies such as IVF.
    Type: Grant
    Filed: May 3, 2007
    Date of Patent: February 22, 2011
    Assignee: Advanced Cell Technology, Inc.
    Inventors: Young Gie Chung, Robert Lanza, Irina V. Klimanskaya
  • Patent number: 7838727
    Abstract: This present invention provides novel methods for deriving embryonic stem cells, those cells and cell lines, and the use of the cells for therapeutic and research purposes without the destruction of the embryo. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e.g., in conjunction with reproductive therapies such as IVF.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: November 23, 2010
    Assignee: Advanced Cell Technology, Inc.
    Inventors: Robert Lanza, Young Chung, Michael D. West
  • Patent number: 7794704
    Abstract: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
    Type: Grant
    Filed: January 24, 2005
    Date of Patent: September 14, 2010
    Assignee: Advanced Cell Technology, Inc.
    Inventors: Irina V. Klimanskaya, Robert Lanza
  • Patent number: 7795025
    Abstract: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
    Type: Grant
    Filed: July 21, 2006
    Date of Patent: September 14, 2010
    Assignee: Advanced Cell Technology, Inc.
    Inventors: Irina V. Klimanskaya, Robert Lanza
  • Patent number: 7736896
    Abstract: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
    Type: Grant
    Filed: July 20, 2005
    Date of Patent: June 15, 2010
    Assignee: Advanced Cell Technology, Inc.
    Inventors: Irina Klimanskaya, Robert Lanza
  • Patent number: 7696404
    Abstract: An improved method of nuclear transfer involving the transplantation of differentiated donor cell nuclei into enucleated oocytes of a species different from the donor cell is provided. The resultant nuclear transfer units are useful for the production of isogenic embryonic stem cells, in particular human isogenic embryonic or stem cells. These embryonic or stem-like cells are useful for producing desired differentiated cells and for introduction, removal or modification, of desired genes, e.g., at specific sites of the genome of such cells by homologous recombination. These cells, which may contain a heterologous gene, are especially useful in cell transplantation therapies and for in vitro study of cell differentiation. Also, methods for improving nuclear transfer efficiency by genetically altering donor cells to inhibit apoptosis, select for a specific cell cycle and/or enhance embryonic growth and development are provided.
    Type: Grant
    Filed: December 27, 2002
    Date of Patent: April 13, 2010
    Assignee: Advanced Cell Technology, Inc.
    Inventors: Jose Cibelli, Michael D. West