Abstract: The present invention relates to a compound comprising a PYY peptide or a functional derivative thereof, which is coupled to a reactive group. Such a reactive group is capable of reacting on a blood component so as to form a stable covalent bond therewith. The present invention also relates to a conjugate comprising such a compound which is covalently bonded to a blood component. Moreover, the invention also relates to a method of enhancing, in a patient, the anti-obesity activity of a PYY peptide or functional derivative thereof.
Type:
Grant
Filed:
October 24, 2007
Date of Patent:
March 15, 2011
Assignee:
Advanced Diagnostics and Discovery
Inventors:
Dominique P. Bridon, Roger Leger, Xicai Huang, Karen Thibaudeau, Martin Robitaille, Peter G. Milner