Abstract: Systems and methods for generating a film suitable for medical packaging are provided. The film is generated by blown film co-extrusion to form a multi-layer film which has a heat resistant layer, a barrier layer and a heat seal layer. The barrier layer includes a high barrier resin and a branched co-polymer. The high barrier resin has a density of at least 0.963 g/cm3. The barrier layer includes between 25% and 85% high barrier resin. In some embodiments, an additional laminate layer may be affixed to the heat resistant layer of the multi-layer film. The final film is between 3.0 and 3.8 mils in thickness, and has a moisture vapor transmission rate of less than 0.08.