Patents Assigned to Advanced Gene Technology, Corp
  • Publication number: 20070009965
    Abstract: The present invention provides a novel method of using an herbal chip for screening for candidate compounds as a GPCR agonist or antagonist from herbs by using a labeled anti-GPCR-GPCR as a probe for hybridization.
    Type: Application
    Filed: December 29, 2004
    Publication date: January 11, 2007
    Applicant: Advanced Gene Technology, Corp.
    Inventors: Li-Wei Hsu, Su-Chen Chang, Chen-Hsiang Shen, Bang-Chi In
  • Publication number: 20060263449
    Abstract: The present invention provides a method for treating arthritic disorders, skin inflammatory disorders and pain, comprising administering to a subject an extract of Andrographis paniculata Nees, and also provides a herbal composition used therefor that comprises the extract of Andrographis paniculata Nees.
    Type: Application
    Filed: May 20, 2005
    Publication date: November 23, 2006
    Applicant: Advanced Gene Technology, Corp.
    Inventors: Li-Wei Hsu, Su-Chen Chang, Kuo-Sheng Chuang, Hsuan-Yi Lin, Jyh-chong Chen
  • Publication number: 20060105967
    Abstract: The use of flavone derivatives of formula (I) in which R1, R2, R3, R4 and R5 independently represent hydrogen, hydroxy or an ester group; R6 represents hydrogen, hydroxy, an ester group or an O-glycoside group such as O-rhamnose, O-glucoside, O-retinoside or O-xyloside; and represents a single bond or a double bond; or the pharmaceutically acceptable salts thereof as TNF? antagonists or inhibitors.
    Type: Application
    Filed: November 18, 2004
    Publication date: May 18, 2006
    Applicant: Advanced Gene Technology, Corp.
    Inventors: Li-Wei Hsu, Su-Chen Chang, Chen-Hsiang Shen, Yuan-Xiu Liao, Kuo-Sheng Chuang
  • Publication number: 20060106098
    Abstract: The present invention relates to andrographolide and its derivatives of the general formula (I), as well as the stereoisomers and salts of andrographolide and the derivatives. Andrographolide and its derivatives represented by general formula (I) defined above are useful as TNF? (tumor necrosis factor alpha) antagonists or inhibitors which have inhibitory effect on the binding of TNF? to TNF-RI. Andrographolide exhibited inhibitor activity with IC50 values 60 ?M on L929 cell proliferation/cytotoxicity assay without cell cytotoxicity. In addition, in the animal model test of collagen-induced arthritis, andrographolide exhibited 50% paw edema. Andrographolide and its derivatives are promising sources with high TNF?-inhibiting or antagonizing activity.
    Type: Application
    Filed: November 18, 2004
    Publication date: May 18, 2006
    Applicant: Advanced Gene Technology, Corp.
    Inventors: Li-Wei Hsu, Su-Chen Chang, Chen-Hsiang Shen, Kuo-Sheng Chuang
  • Patent number: 6930097
    Abstract: A compound of formula 1-[3,4-dihydroxy-5-(2-hydroxyethyl)tetrahydrofuran-2-yl]pryimidine-2,4(1H,3H)-dione has inhibitory effects of matrix metalloproteinase-2 (gelatinase A) enzyme and binding of TNF? to TNF?-RI.
    Type: Grant
    Filed: April 21, 2003
    Date of Patent: August 16, 2005
    Assignee: Advanced Gene Technology Corp.
    Inventors: Li-Wei Hsu, Su-Chen Chang, Jeng-Woei Lee, Pang-Hsi Liu, Hui-Ping Lee, Yi-Ching Chen, Chun-Tsun Chen
  • Patent number: 6908678
    Abstract: The present invention discloses a chemically surface-treated plastic slide that is useful for the immobilization of proteins, peptides or small molecules to its surface for the fabrication of biochips. Also disclosed in the present invention is a surface-treated plastic slide made of polystyrene, which is useful for the immobilization of oligonucleotides or polynucleotides to its treated surface for the fabrication of DNA chips.
    Type: Grant
    Filed: January 18, 2002
    Date of Patent: June 21, 2005
    Assignee: Advanced Gene Technology, Corp.
    Inventors: Li-Wei Hsu, Su-Chen Chang, Jyh-Phen Chen, Jeng-Woei Lee
  • Patent number: 6884627
    Abstract: The present invention discloses a method for ascertaining the quality of herbs by applying the techniques of biochip for detecting the presence of biologically active, desired ingredient(s) in the herbs.
    Type: Grant
    Filed: April 5, 2002
    Date of Patent: April 26, 2005
    Assignee: Advanced Gene Technology, Corp.
    Inventors: Li-Wei Hsu, Su-Chen Chang
  • Patent number: 6855343
    Abstract: The present invention relates to a novel method useful for fast separation and quick identification of active ingredients in herbs. The separation procedures are efficient without tedious and time-consuming works by using chromatographies or HPLC. The present invention further relates to a method for ascertaining the quality of herbs by applying treated plastic slides on quality control of herbal fractions, based on identification of their biological activities.
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: February 15, 2005
    Assignee: Advanced Gene Technology, Corp
    Inventors: Li-Wei Hsu, Su-Chen Chang
  • Patent number: 6683060
    Abstract: The invention discloses methods of treatment and prevention for TNF&agr;-related disorders and MMP-related disorders and compounds useful in such treatments. In particular, the invention dislcoses pharmaceutical compositions comprising a compound of the general formula: wherein X is a Zn(II) chelating group and selected from the group consisting of (CH2)nOH, (CH2)nNH2, (CH2)nSH, (CH2)mCOOH, (CH2)mCOOR, (CH2)mCONH2, (CH2)m″CONH—OH, (CH2)m″CONH—R, and (CH2)n′O(PO3)m″(m″+1), wherein n=2, 3, 4, or 5, n′=2 or 3, m=1, 2, 3, or 4, m′=1, 2, 3, 4, 5, or 6, m″=1, 2, 3, and R=—Cm′, H2m′+1 or aryl groups, especially 1-[3,4-dihydroxy-5-(2-hydroxyethyl)-tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione, which has an inhibitory effect on matrix metalloproteinase-2 (gelatinase A) and on the binding of TNF&agr; to TNF&agr;-RI.
    Type: Grant
    Filed: February 25, 2002
    Date of Patent: January 27, 2004
    Assignee: Advanced Gene Technology Corp.
    Inventors: Li-Wei Hsu, Su-Chen Chang, Jeng-Woei Lee, Pang-Hsi Liu, Hui-Ping Lee, Yi-Ching Chen, Chun-Tsun Chen