Patents Assigned to Advanced Gene Technology, Corp
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Publication number: 20070009965Abstract: The present invention provides a novel method of using an herbal chip for screening for candidate compounds as a GPCR agonist or antagonist from herbs by using a labeled anti-GPCR-GPCR as a probe for hybridization.Type: ApplicationFiled: December 29, 2004Publication date: January 11, 2007Applicant: Advanced Gene Technology, Corp.Inventors: Li-Wei Hsu, Su-Chen Chang, Chen-Hsiang Shen, Bang-Chi In
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Publication number: 20060263449Abstract: The present invention provides a method for treating arthritic disorders, skin inflammatory disorders and pain, comprising administering to a subject an extract of Andrographis paniculata Nees, and also provides a herbal composition used therefor that comprises the extract of Andrographis paniculata Nees.Type: ApplicationFiled: May 20, 2005Publication date: November 23, 2006Applicant: Advanced Gene Technology, Corp.Inventors: Li-Wei Hsu, Su-Chen Chang, Kuo-Sheng Chuang, Hsuan-Yi Lin, Jyh-chong Chen
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Publication number: 20060105967Abstract: The use of flavone derivatives of formula (I) in which R1, R2, R3, R4 and R5 independently represent hydrogen, hydroxy or an ester group; R6 represents hydrogen, hydroxy, an ester group or an O-glycoside group such as O-rhamnose, O-glucoside, O-retinoside or O-xyloside; and represents a single bond or a double bond; or the pharmaceutically acceptable salts thereof as TNF? antagonists or inhibitors.Type: ApplicationFiled: November 18, 2004Publication date: May 18, 2006Applicant: Advanced Gene Technology, Corp.Inventors: Li-Wei Hsu, Su-Chen Chang, Chen-Hsiang Shen, Yuan-Xiu Liao, Kuo-Sheng Chuang
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Publication number: 20060106098Abstract: The present invention relates to andrographolide and its derivatives of the general formula (I), as well as the stereoisomers and salts of andrographolide and the derivatives. Andrographolide and its derivatives represented by general formula (I) defined above are useful as TNF? (tumor necrosis factor alpha) antagonists or inhibitors which have inhibitory effect on the binding of TNF? to TNF-RI. Andrographolide exhibited inhibitor activity with IC50 values 60 ?M on L929 cell proliferation/cytotoxicity assay without cell cytotoxicity. In addition, in the animal model test of collagen-induced arthritis, andrographolide exhibited 50% paw edema. Andrographolide and its derivatives are promising sources with high TNF?-inhibiting or antagonizing activity.Type: ApplicationFiled: November 18, 2004Publication date: May 18, 2006Applicant: Advanced Gene Technology, Corp.Inventors: Li-Wei Hsu, Su-Chen Chang, Chen-Hsiang Shen, Kuo-Sheng Chuang
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Patent number: 6930097Abstract: A compound of formula 1-[3,4-dihydroxy-5-(2-hydroxyethyl)tetrahydrofuran-2-yl]pryimidine-2,4(1H,3H)-dione has inhibitory effects of matrix metalloproteinase-2 (gelatinase A) enzyme and binding of TNF? to TNF?-RI.Type: GrantFiled: April 21, 2003Date of Patent: August 16, 2005Assignee: Advanced Gene Technology Corp.Inventors: Li-Wei Hsu, Su-Chen Chang, Jeng-Woei Lee, Pang-Hsi Liu, Hui-Ping Lee, Yi-Ching Chen, Chun-Tsun Chen
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Patent number: 6908678Abstract: The present invention discloses a chemically surface-treated plastic slide that is useful for the immobilization of proteins, peptides or small molecules to its surface for the fabrication of biochips. Also disclosed in the present invention is a surface-treated plastic slide made of polystyrene, which is useful for the immobilization of oligonucleotides or polynucleotides to its treated surface for the fabrication of DNA chips.Type: GrantFiled: January 18, 2002Date of Patent: June 21, 2005Assignee: Advanced Gene Technology, Corp.Inventors: Li-Wei Hsu, Su-Chen Chang, Jyh-Phen Chen, Jeng-Woei Lee
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Patent number: 6884627Abstract: The present invention discloses a method for ascertaining the quality of herbs by applying the techniques of biochip for detecting the presence of biologically active, desired ingredient(s) in the herbs.Type: GrantFiled: April 5, 2002Date of Patent: April 26, 2005Assignee: Advanced Gene Technology, Corp.Inventors: Li-Wei Hsu, Su-Chen Chang
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Patent number: 6855343Abstract: The present invention relates to a novel method useful for fast separation and quick identification of active ingredients in herbs. The separation procedures are efficient without tedious and time-consuming works by using chromatographies or HPLC. The present invention further relates to a method for ascertaining the quality of herbs by applying treated plastic slides on quality control of herbal fractions, based on identification of their biological activities.Type: GrantFiled: May 21, 2002Date of Patent: February 15, 2005Assignee: Advanced Gene Technology, CorpInventors: Li-Wei Hsu, Su-Chen Chang
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Patent number: 6683060Abstract: The invention discloses methods of treatment and prevention for TNF&agr;-related disorders and MMP-related disorders and compounds useful in such treatments. In particular, the invention dislcoses pharmaceutical compositions comprising a compound of the general formula: wherein X is a Zn(II) chelating group and selected from the group consisting of (CH2)nOH, (CH2)nNH2, (CH2)nSH, (CH2)mCOOH, (CH2)mCOOR, (CH2)mCONH2, (CH2)m″CONH—OH, (CH2)m″CONH—R, and (CH2)n′O(PO3)m″(m″+1), wherein n=2, 3, 4, or 5, n′=2 or 3, m=1, 2, 3, or 4, m′=1, 2, 3, 4, 5, or 6, m″=1, 2, 3, and R=—Cm′, H2m′+1 or aryl groups, especially 1-[3,4-dihydroxy-5-(2-hydroxyethyl)-tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione, which has an inhibitory effect on matrix metalloproteinase-2 (gelatinase A) and on the binding of TNF&agr; to TNF&agr;-RI.Type: GrantFiled: February 25, 2002Date of Patent: January 27, 2004Assignee: Advanced Gene Technology Corp.Inventors: Li-Wei Hsu, Su-Chen Chang, Jeng-Woei Lee, Pang-Hsi Liu, Hui-Ping Lee, Yi-Ching Chen, Chun-Tsun Chen