Patents Assigned to Advanced Inhalation Research, Inc.
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Publication number: 20080241253Abstract: Particles having a tap density less than about 0.4 g/cm3 are formed by spray drying from a colloidal solution including a carboxylic acid or salt thereof, a phospholipid, a divalent salt and a solvent such as an aqueous-organic solvent. The colloidal solution can also include a therapeutic, prophylactic or diagnostic agent. Preferred carboxylic acids include at least two carboxyl groups. Preferred phospholipids include phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols, phophstidylserines, phosphatidylinositols and combinations thereof. The particles are suitable for pulmonary delivery.Type: ApplicationFiled: October 4, 2007Publication date: October 2, 2008Applicant: Advanced Inhalation Research, Inc.Inventors: Michael M. Lipp, Richard P. Batycky, Giovanni Caponetti
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Publication number: 20080160092Abstract: Particles having a tap density of less than 0.4 g/cm3 include a hydrophobic amino acid or salt thereof and a therapeutic, prophylactic or diagnostic agent or any combination thereof. Preferred particles include a phospholipid, have a median geometric diameter between about 5 and about 30 microns and an aerodynamic diameter between about 1 and about 5 microns. The particles can be formed by spray-drying and are useful for delivery to the pulmonary system.Type: ApplicationFiled: October 17, 2007Publication date: July 3, 2008Applicant: Advanced Inhalation Research, Inc.Inventors: Richard P. Batycky, Michael M. Lipp, Ralph W. Niven
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Publication number: 20080160098Abstract: Particles having a tap density of less than 0.4 g/cm3 include a hydrophobic amino acid or salt thereof and a therapeutic, prophylactic or diagnostic agent or any combination thereof. Preferred particles include a phospholipid, have a median geometric diameter between about 5 and about 30 microns and an aerodynamic diameter between about 1 and about 5 microns. The particles can be formed by spray-drying and are useful for delivery to the pulmonary system.Type: ApplicationFiled: October 17, 2007Publication date: July 3, 2008Applicant: Advanced Inhalation Research, Inc.Inventors: Richard P. Batycky, Michael M. Lipp, Ralph W. Niven
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Patent number: 7384649Abstract: This invention concerns an improved particulate composition for delivering a drug to the pulmonary system. Applicants disclose a method of identifying an optimal form of aerodynamically light particles which are highly dispersible. The particles of the instant invention are made by creating hollow, spherical drug particles (i.e., progenitor particles) that collapse in the process of particle formation, leading to wrinkled, thin-walled drug particles of very low envelope density. Additionally, Applicants have found that such particles are especially optimal for inhaled aerosols when the surface area parameter (?) is greater than 2, optimally greater than 3.Type: GrantFiled: December 5, 2006Date of Patent: June 10, 2008Assignee: Advanced Inhalation Research, Inc.Inventors: Richard P. Batycky, David A. Edwards, Michael M. Lipp
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Publication number: 20080063722Abstract: The present invention is related to pharmaceutical formulations and methods of treating a subject afflicted with the influenza virus, the method includes administering to the respiratory tract of the patient particles that include more than about 5% to about 50% weight percent (wt %) of a neuraminidase inhibitor. The particles are delivered to the patient's pulmonary system, including the upper airways, central airways and deep lung.Type: ApplicationFiled: August 14, 2007Publication date: March 13, 2008Applicant: Advanced Inhalation Research, Inc.Inventors: Kevin Ward, Thean Yeoh, Rebecca Martin, Charles Blizzard
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Patent number: 7279182Abstract: Particles having a tap density less than about 0.4 g/cm3 are formed by spray drying from a colloidal solution including a carboxylic acid or salt thereof, a phospholipid, a divalent salt and a solvent such as an aqueous-organic solvent. The colloidal solution can also include a therapeutic, prophylactic or diagnostic agent. Preferred carboxylic acids include at least two carboxyl groups. Preferred phospholipids include phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols, phophstidylserines, phosphatidylinositols and combinations thereof. The particles are suitable for pulmonary delivery.Type: GrantFiled: April 28, 2004Date of Patent: October 9, 2007Assignee: Advanced Inhalation Research, Inc.Inventors: Michael W. Lipp, Richard P. Batycky, Giovanni Caponetti
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Patent number: 7252840Abstract: Particles having a tap density of less than 0.4 g/cm3 include a hydrophobic amino acid or salt thereof and a therapeutic, prophylactic or diagnostic agent or any combination thereof. Preferred particles include a phospholipid, have a median geometric diameter between about 5 and about 30 microns and an aerodynamic diameter between about 1 and about 5 microns. The particles can be formed by spray-drying and are useful for delivery to the pulmonary system.Type: GrantFiled: August 23, 2000Date of Patent: August 7, 2007Assignee: Advanced Inhalation Research, Inc.Inventors: Richard P. Batycky, Michael M. Lipp, Ralph W. Niven
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Publication number: 20070131576Abstract: A packaging for a receptacle loadable into an inhaler for pulmonary delivery of the contents of the receptacle. The packaging includes a base and a cover, which base has a surface defining a well that accommodates the receptacle. The well-defining surface includes a first region and a differently shaped second region, which first surface region is shaped to support the receptacle in alignment within the well, and which second surface region accommodates a first end of the receptacle aligned in the well and has a mouth geometry enlarged from the first surface region to allow a portion of an inhaler to be inserted therein to receive the first end of the receptacle for scooping the receptacle into the inhaler from the well.Type: ApplicationFiled: November 6, 2006Publication date: June 14, 2007Applicants: Advanced Inhalation Research, Inc., Eli Lilly and CompanyInventors: Peter Ehling, William Hundley, Ethan Jacoby, Rodney Monson
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Publication number: 20070123449Abstract: The invention generally relates to formulations having particles comprising phospholipids, bioactive agent and excipients and the pulmonary delivery thereof. Dry powder inhaled insulin formulations are disclosed. Improved formulations comprising DPPC, insulin and sodium citrate which are useful in the treatment of diabetes are disclosed. Also, the invention relates to a method of for the pulmonary delivery of a bioactive agent comprising administering to the respiratory tract of a patient in need of treatment, or diagnosis an effective amount of particles comprising a bioactive agent or any combination thereof in association, wherein release of the agent from the administered particles occurs in a rapid fashion.Type: ApplicationFiled: October 31, 2006Publication date: May 31, 2007Applicant: Advanced Inhalation Research, Inc.Inventors: Henry Brush, Fen-Ni Fu, Michael Lipp, Jennifer Schmitke
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Patent number: 7182961Abstract: This invention concerns an improved particulate composition for delivering a drug to the pulmonary system. Applicants disclose a method of identifying an optimal form of aerodynamically light particles which are highly dispersible. The particles of the instant invention are made by creating hollow, spherical drug particles (i.e., progenitor particles) that collapse in the process of particle formation, leading to wrinkled, thin-walled drug particles of very low envelope density. Additionally, Applicants have found that such particles are especially optimal for inhaled aerosols when the surface area parameter (?) is greater than 2, optimally greater than 3.Type: GrantFiled: November 20, 2002Date of Patent: February 27, 2007Assignee: Advanced Inhalation Research, Inc.Inventors: Richard P. Batycky, David A. Edwards, Michael M. Lipp
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Publication number: 20070041912Abstract: The invention relates to a method for treating a disease characterized by a constrictive airway comprising administering to a patient in need thereof via inhalation a pharmaceutical composition comprising trospium, wherein said patient achieves an effective therapy for at least 10 hours. The trospium composition is preferably a particulate formulation useful for administration via a dry powder inhaler. In a preferred embodiment, the composition further comprises a second active agent, such as a beta-2 agonist. A particularly preferred second active agent is formoterol, wherein the trospium, formoterol composition is manufactured by spray drying a mixture comprising trospium and formoterol.Type: ApplicationFiled: September 4, 2003Publication date: February 22, 2007Applicant: ADVANCED INHALATION RESEARCH, INC.Inventors: Elliot Ehrich, Daniel Deaver, Robert Clarke, Michael Lipp
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Publication number: 20060283448Abstract: Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber to achieve a higher reproducible emitted dose of medicament from the receptacle. The inhalation device also includes an improved implement for puncturing the receptacle, requiring less force and experiencing fewer failures.Type: ApplicationFiled: August 30, 2006Publication date: December 21, 2006Applicant: Advanced Inhalation Research, Inc.Inventors: David Edwards, Mark DeLong, Craig Dunbar, Ernest Penachio, Kevin Stapleton, Mark Wolff
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Patent number: 7146978Abstract: Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber to achieve a higher reproducible emitted dose of medicament from the receptacle. The inhalation device also includes an improved implement for puncturing the receptacle, requiring less force and experiencing fewer failures.Type: GrantFiled: February 5, 2004Date of Patent: December 12, 2006Assignee: Advanced Inhalation Research, Inc.Inventors: David Edwards, Mark DeLong, Craig Dunbar, Ernest E. Penachio, Kevin Stapleton, Mark Wolff
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Patent number: 7048908Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.Type: GrantFiled: July 23, 2002Date of Patent: May 23, 2006Assignee: Advanced Inhalation Research, Inc.Inventors: Sujit K. Basu, Jeffrey Hrkach, Michael Lipp, Katharina Elbert, David A. Edwards
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Patent number: 7032593Abstract: Inhaler and associated method for facilitating inhalation of dry powder medicaments by a patient. The inhaler is light and compact, allowing for convenient storage and portability by a patient. Additionally, a minimal number of steps are required by the patient to use the device from start to finish. The inhaler is self-contained, being provided to the patient with medicament having been pre-stored in a powder chamber. Upon release from this chamber, an accurate dosage of the dry powder medicament is available for inhalation. The inhaler may simply be disposed of following use.Type: GrantFiled: April 17, 2002Date of Patent: April 25, 2006Assignee: Advanced Inhalation Research, Inc.Inventors: Lloyd P. Johnston, Kevin Stapleton
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Patent number: 7008644Abstract: Method and apparatus for producing dry particles. Two liquid components are combined in a static mixer, atomized into droplets, and the droplets dried to form dry particles. Use of the static mixer enables incompatible liquid components to be rapidly and homogeneously combined. The present invention optimizes process conditions for increasing and controlling particle porosity. The present invention also allows for optimization of particle size in real-time during particle production.Type: GrantFiled: March 20, 2002Date of Patent: March 7, 2006Assignee: Advanced Inhalation Research, Inc.Inventors: Richard P. Batycky, Blair C. Jackson, Lloyd P. Johnston, Jeffrey D. Mintzes, Ernest E. Penachio
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Publication number: 20060039987Abstract: Method and apparatus for producing dry particles. Two liquid components are combined in a static mixer, atomized into droplets, and the droplets dried to form dry particles. Use of the static mixer enables incompatible liquid components to be rapidly and homogeneously combined. The present invention optimizes process conditions for increasing and controlling particle porosity. The present invention also allows for optimization of particle size in real-time during particle production.Type: ApplicationFiled: October 24, 2005Publication date: February 23, 2006Applicant: Advanced Inhalation Research, Inc.Inventors: Richard Batycky, Blair Jackson, Lloyd Johnston, Jeffrey Mintzes, Ernest Penachio
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Patent number: 6979437Abstract: A method for treating a disorder of the central nervous system includes administering to the respiratory tract of a patient a drug which is delivered to the pulmonary system, for instance to the alveoli or the deep lung. The drug is administered at a dose which is at least about two-fold less than the dose required by oral administration. Particles that include the drug can be employed. Preferred particles have a tap density of less than about 0.4 g/cm3. In addition to the medicament, the particles can include other materials such as, for example, phospholipids, amino acids, combinations thereof and others.Type: GrantFiled: May 20, 2003Date of Patent: December 27, 2005Assignee: Advanced Inhalation Research, Inc.Inventors: Raymond T. Bartus, Dwaine F. Emerich
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Patent number: 6959522Abstract: Method and apparatus for providing a precisely controlled amount of dry material to a container. In one embodiment, a system is provided for automated container filling. The system includes a container handling mechanism that includes a container block defining a container receptacle, and a cap carrier defining a cap receptacle. The system also includes a dosing portion having a dosing plate defining a dosing hole. The dosing plate is movable between two positions so that when the dosing plate is in the first position the dosing hole is positioned to receive a dose of powder. When the dosing plate is in the second position, the dosing hole is positioned to dispense the dose of powder into the container receptacle.Type: GrantFiled: February 23, 2004Date of Patent: November 1, 2005Assignee: Advanced Inhalation Research, Inc.Inventors: Lloyd P. Johnston, Kevin Stapleton, Ernest Penachio, Mark Wolff
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Patent number: 6956021Abstract: Spray-dried particles having improved protein stability are produced by spray-drying a mixture including a protein, a phospholipid and an organic-aqueous co-solvent. Spray-dried particles which include at least 1 weight % phospholipid, having a tap density of less than 0.4 g/cm3 can be prepared. The particles can be delivered to the pulmonary system of a patient.Type: GrantFiled: August 25, 1999Date of Patent: October 18, 2005Assignee: Advanced Inhalation Research, Inc.Inventors: David A. Edwards, Jeffrey S. Hrkach