Abstract: A system and method for optimizing radiological workflow management and medical image review is disclosed. A preferred embodiment provides a system interoperable with various RIS and PACS systems and that provides efficient access to information, a dynamic prioritized worklist that constantly changes to address optimize distribution of studies and timely review. The novel system facilitates automated assignment, communication between physicians, technicians and radiologists regarding orders, radiographs, reports and studies. The system analyzes exam data, urgency and pendency times, among other things, to automatically determine an overall priority for each case. Cases are assigned for review in the most efficient time, resulting in optimal turnaround time and improved patient care.