Abstract: The present disclosure relates to a cryocooling system and method. The system includes a sample well and a sample chamber, each of which having an interior that is sized and shaped to hold a cryocooling gas at cryogenic temperatures and a pressure below 1 atm. The sample chamber is also sized and shaped to hold a sample substance to be cryocooled. An impedance tube connects the interior of the sample well to the interior of the sample chamber to allow cryocooling gas to move from the sample well to the sample chamber. A vacuum tube is connected to the interior of the sample chamber on one side and to a vacuum pump via a vacuum port on the other. The vacuum tube is sized and shaped to allow cryocooling gas within the sample chamber to be pumped out of the sample chamber by the vacuum pump.