Abstract: The invention relates to novel nucleic acids encoding a fibroblast growth factor-23(FGF23) and proteins encoded thereby, mutations in which are associated with autosomal dominant rickets (ADHR). The invention further relates to methods of diagnosing and treating hypophosphatemic and hyperphosphatemic disorders comprising inhibiting or stimulating, respectively, the biological activity of FGF23 in a patient. The invention also relates to methods of treating osteoporosis, dermatomyositis, and coronary artery disease comprising stimulating the biological activity of FGF23 in a patient.
Type:
Application
Filed:
March 4, 2003
Publication date:
September 25, 2003
Applicant:
Advanced Research & Technology Institute and Ludwig-Maximilians-Universitat Munchen
Inventors:
Michael Econs, Ken White, Tim Matthias Strom, Thomas Meitinger
Abstract: The invention relates to novel nucleic acids encoding a fibroblast growth factor-23(FGF23) and proteins encoded thereby, mutations in which are associated with autosomal dominant rickets (ADHR). The invention further relates to methods of diagnosing and treating hypophosphatemic and hyperphosphatemic disorders comprising inhibiting or stimulating, respectively, the biological activity of FGF23 in a patient. The invention also relates to methods of treating osteoporosis, dermatomyositis, and coronary artery disease comprising stimulating the biological activity of FGF23 in a patient.
Type:
Application
Filed:
July 10, 2001
Publication date:
October 24, 2002
Applicant:
Advanced Research & Technology Institute and Ludwig-Maximilians-Universitat Munchen
Inventors:
Michael Econs, Ken White, Tim Matthias Strom, Thomas Meitinger