Abstract: A dual chamber applicator includes an elongated tube having a sealed end and an open end, a first ampoule disposed in the elongated tube and containing a first composition including a pharmaceutically active agent and optionally a first volatile solvent, water, or a combination thereof, a second ampoule disposed in the elongated tube and containing a second composition including a resin based tincture, a second volatile solvent and water, and an applicator device provided at the open end of the elongated tube. The first composition is configured to combine with the second composition within the elongated tube to form a medicine to be delivered to a mucosal site or a skin site. The applicator device is configured to control flow of the medicine out of the open end of the elongated tube and deliver the medicine via topical, transdermal or transmucosal delivery.