Patents Assigned to Advanced Technologies and Regenerative Medicine, LLC
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Publication number: 20120302427Abstract: A biologic-adsorbent, e.g., protein-adsorbent, material is prepared by forming a polymeric substrate into structures having high surface area topography whose biologic adsorbing properties can be controlled. Biologic adsorption by these structures of optimized high surface area topography is increased by mild treating of the surfaces, e.g., by oxygen plasma, without substantially altering topography. Structures can have tailored geometric features including microstructures, e.g., pillars, with a diameter from 100 nm-50 ?m and height greater than 1 ?m.Type: ApplicationFiled: December 29, 2011Publication date: November 29, 2012Applicants: ADVANCED TECHNOLOGIES & REGENERATIVE MEDICINE, LLCInventors: Noha Elmouelhi, Kevin Cooper, Sriram Natarajan, Hong Yee Low, Isabel Rodriguez, Emma Kim Luong-Van
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Publication number: 20120302465Abstract: A biologic-adsorbent, e.g., protein-adsorbent, material is prepared by forming a polymeric substrate into structures having high surface area topography whose biologic adsorbing properties can be controlled. Biologic adsorption by these structures of optimized high surface area topography is increased by mild treating of the surfaces, e.g., by oxygen plasma, without substantially altering topography. Structures can have tailored geometric features including microstructures, e.g., pillars, with a diameter from 100 nm-50 ?m and height greater than 1 ?m.Type: ApplicationFiled: May 26, 2011Publication date: November 29, 2012Applicants: AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH, ADVANCED TECHNOLOGIES & REGENERATIVE MEDICINE, LLCInventors: Noha ELMOUELHI, Kevin COOPER, Sriram NATARAJAN, Hong Yee LOW, Isabel RODRIGUEZ, Emma Kim LUONG-VAN
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Publication number: 20120301958Abstract: This application invention discloses bioartificial proximal tubule device, constructed by preparing a decellularized biological matrix, seeding the biological matrix with mammalian kidney-derived cells and optionally mammalian endothelial cells. The device may then be cultured statically or matured using bioreactor culture to allow differentiation of the kidney cells into functioning proximal tubule cells. The device is capable of carrying out proximal tubule functions. The application also describes various methods of making the proximal tubule devices. The application also further describes methods of use of bioartificial proximal tubule devices for e.g. in vitro studies of tubule cell transport, toxicity effects of various compounds or pharmaceutical compound screening.Type: ApplicationFiled: May 25, 2012Publication date: November 29, 2012Applicant: Advanced Technologies and Regenerative Medicine, LLCInventors: Christian Kazanecki, David C. Colter, Johanna Schanz, Anke Hoppensack, Jan Hansmann, Heike Walles
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Patent number: 8318483Abstract: Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.Type: GrantFiled: July 6, 2006Date of Patent: November 27, 2012Assignee: Advanced Technologies and Regenerative Medicine, LLCInventors: Sanjay Mistry, Anthony J. Kihm, Ian Ross Harris, Alexander M. Harmon, Darin J. Messina, Agnieszka Seyda, Anna Gosiewska
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Publication number: 20120251611Abstract: A polydioxanone film comprising substantially cylindrical polydioxanone pillars on at least one side thereof, said pillars having diameters from about 0.2 ?m to about 3 ?m, and heights from about 2 ?m to about 20 ?m from the surface of the film, a process for adsorbing proteins using the film and medical devices incorporating the film.Type: ApplicationFiled: March 30, 2012Publication date: October 4, 2012Applicants: AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH, ADVANCED TECHNOLOGIES & REGENERATIVE MEDICINE, LLCInventors: Emma Kim Luong-Van, Isabel Rodriguez, Hong Yee Low, Noha Elmouelhi, Kevin Cooper, Sriram Natarajan, Murty N. Vyakarnam, Chee Tiong Lim
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Patent number: 8277831Abstract: The present invention includes methods for the inhibition of post-operative adhesion formation between tissue surfaces in a body cavity having been subjected to a surgical procedure, which methods involve administering Pemirolast, or an analog thereof, directly to tissue surfaces in the body cavity in amounts and under conditions effective to inhibit formation of adhesions, and to delivery vehicles and compositions suitable for use for local, non-systemic administration of a drug to the body and directly to tissue within a body cavity having been subjected to a surgical procedure.Type: GrantFiled: February 17, 2004Date of Patent: October 2, 2012Assignee: Advanced Technologies and Regenerative Medicine, LLC.Inventors: Janel E. Young, Scott A. Wadsworth, Kevin Cooper, Joel Rosenblatt, Han Cui
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Patent number: 8277796Abstract: Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.Type: GrantFiled: April 24, 2009Date of Patent: October 2, 2012Assignee: Advanced Technologies and Regenerative Medicine, LLCInventors: Darin J. Messina, Sanjay Mistry, Alexander M. Harmon, Ian Ross Harris, Anthony J. Kihm, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
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Publication number: 20120213743Abstract: Compositions and methods of using cells derived from umbilical cord tissue, to stimulate and support angiogenesis, to improve blood flow, to regenerate, repair, and improve skeletal muscle damaged by a peripheral ischemic event, and to protect skeletal muscle from ischemic damage in peripheral vascular disease patients are disclosed. In particular, methods of treating a patient having a peripheral vascular disease with umbilical derived cells and fibrin glue are disclosed.Type: ApplicationFiled: August 10, 2011Publication date: August 23, 2012Applicant: Advanced Technologies and Regenerative Medicine, LLCInventors: Charito S. Buensuceso, Anthony J. Kihm, Sridevi Dhanaraj, Roee Atlas, Israel Nur, Roberto Meidler, Liliana Bar
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Patent number: 8236538Abstract: Provided are methods for sterilizing a material comprising a biologically-active agent comprising irradiating said material with ionizing radiation at a dose of about 5 kGy to about 25 kGy while maintaining said material in an atmosphere comprising at least 95% by volume inert gas and at a temperature of about 4° C. or lower. Also provided are sterilized materials comprising a biologically-active agent, wherein said materials exhibit substantially the same amount of biological activity as a non-sterilized control.Type: GrantFiled: December 17, 2008Date of Patent: August 7, 2012Assignee: Advanced Technologies and Regenerative Medicine, LLCInventors: Alexander M. Harmon, Laura J. Brown, Charles J. Buckle, Frederick Halperin, Stanko Bodnar
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Publication number: 20120148678Abstract: We have disclosed an implantable sustained release composition comprising, a biocompatible, biodegradable polymer, a cyclodextrin inclusion complex of a poorly water soluble pharmaceutical agent present, and a plasticizer, where the polymer is the minority phase of the formulation. Furthermore, The we disclose an implantable sustained release composition that provides a detectable plasma level of an otherwise poorly soluble drug for at least 28 days.Type: ApplicationFiled: December 8, 2010Publication date: June 14, 2012Applicant: Advanced Technologies and Regenerative Medicine, LLC.Inventors: Deborah M. Schachter, Qiang Zhang, Peter Van Remoortere, Yufu Li
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Publication number: 20120148674Abstract: We have disclosed dicephalic amphiphiles having peptide sequences as the head groups. We have also disclosed self-assembly hydrogels prepared from the dicephalic peptide amphiphiles. These hydrogels are useful for the encapsulation and delivery of bioactives to a patient.Type: ApplicationFiled: December 8, 2010Publication date: June 14, 2012Applicant: Advanced Technologies and Regenerative Medicine, LLCInventors: Jackie J. Donners, Aruna Nathan
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Patent number: 8197838Abstract: A novel method of preparing a controlled release composition is disclosed. Specifically, the present invention relates to a method of preparing controlled release compositions of ascorbic acid phosphate and absorbable polymers. Also disclosed is a novel controlled release composition of ascorbic acid phosphate made by the method of the present invention.Type: GrantFiled: January 14, 2011Date of Patent: June 12, 2012Assignee: Advanced Technologies and Regenerative Medicine, LLC.Inventors: Yufu Li, Stephen Wohlert, Chunlin Yang
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Publication number: 20120143228Abstract: A laminate and process of making the laminate is disclosed comprising: a surgical mesh having first and second surfaces; and an adhesive structure having adhesive and non-adhesive surfaces, wherein the non-adhesive surface of the adhesive structure is laminated to at least one of said first and second surfaces of said surgical mesh, and the adhesive surface of said adhesive structure has protrusions extending therefrom comprising a resin having a Young's modulus of greater than 17 MPa, which protrusions are of sufficiently low diameter to promote adhesion by increasing physical attractive forces between the adhesive structure and a target surface, as measured by shear adhesion.Type: ApplicationFiled: December 29, 2011Publication date: June 7, 2012Applicants: AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH, ADVANCED TECHNOLOGIES & REGENERATIVE MEDICINE, LLCInventors: Sriram Natarajan, Joseph J. Hammer, Kevin Cooper, Murty N. Vyakarnam, Hong Yee Low, Isabel Rodriguez, Chee Tiong Lim, Audrey Yoke Yee Ho
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Patent number: 8187326Abstract: The present invention relates to tissue scaffold implant devices useful in the repair and/or regeneration of diseased and/or damaged musculoskeletal tissue and that include a tissue scaffold component fixedly attached to a scaffold fixation component via a polymeric adhesive layer, and to methods of making such tissue scaffold implant devices.Type: GrantFiled: May 22, 2002Date of Patent: May 29, 2012Assignee: Advanced Technologies and Regenerative Medicine, LLC.Inventors: Joseph J. Hammer, Joseph H. Contiliano, Murty N. Vyakarnam, Kelly R. Brown
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Publication number: 20120027775Abstract: An absorbable PEG-based hydrogel prepared from a multi-arm-PEG-vinylsulfone having about 3 to about 8 arms and a multi-arm-PEG-R-sulfhydryl having about 3 to about 8 arms; where R is defined as an ester linkage, such as carboxylate ester, lactate ester, and isobutyrate ester have been disclosed. Additionally, sustained release compositions that are prepared from an absorbable PEG-based hydrogel and a protein have been disclosed which provide sustained release of proteins and peptides.Type: ApplicationFiled: July 29, 2011Publication date: February 2, 2012Applicant: Advanced Technologies and Regenerative Medicine, LLCInventors: Chee-Youb Won, Helen Cui
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Publication number: 20120014921Abstract: This invention relates to methods of treating stroke by intranasal administration of umbilical cord tissue-derived cells, which are isolated from mammalian umbilical cord tissue substantially free of blood or expanded in culture from a cell isolated from mammalian umbilical cord tissue substantially free of blood, are capable of self-renewal and expansion in culture, and do not produce CD117 and/or telomerase. The methods of the invention regenerate, repair and improve neural tissue and improve behavior and neurological function in stroke patients.Type: ApplicationFiled: July 15, 2011Publication date: January 19, 2012Applicant: Advanced Technologies and Regenerative Medicine, LLCInventors: Brian C. Kramer, Anthony J. Kihm
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Patent number: 8076294Abstract: The present invention relates to a collagen-related polypeptide (CRP) having hydrophobic amino acid groups at the N- and C-termini capable of non-covalent self-assembly into collagen mimetic triple helices and fibrils thereof and the synthesis, methods of use and compositions thereof.Type: GrantFiled: July 25, 2008Date of Patent: December 13, 2011Assignee: Advanced Technologies and Regenerative Medicine, LLC.Inventors: William A. Kinney, Mabel Alarnino Cejas, Bruce E. Maryanoff, Thomas Matalenas, Chunlin Yang
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Patent number: 8071137Abstract: The invention is a method for the treatment of mammalian articular cartilage disorders, inflammatory joint disease, trauma-related cartilage injuries, and degenerative disc disease. The method involves treating the affected area with a composition containing a therapeutically effective dose of Centella extract. The composition is delivered locally by parenteral administration to the affected site.Type: GrantFiled: March 31, 2008Date of Patent: December 6, 2011Assignee: Advanced Technologies and Regenerative Medicine, LLCInventors: Sridevi Dhanaraj, Carrie H. Fang
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Publication number: 20110280838Abstract: Methods for treating a patient having a disease or condition related to IVD degeneration are provided. The methods comprise administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells and optionally a hydrogel. In some embodiments, administering the cells promotes repair and regeneration of degenerated IVD tissue in the patient. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.Type: ApplicationFiled: May 19, 2011Publication date: November 17, 2011Applicant: Advanced Technologies and Regenerative Medicine, LLCInventors: Brian C. Kramer, Laura J. Brown, Anthony J. Kihm
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Patent number: 8034329Abstract: Methods for treating a patient having a disease or damage to at least one kidney are provided. The methods comprise administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells. When administered, the cells promote and support the repair and regeneration of the diseased or damaged kidney tissue in the patient. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.Type: GrantFiled: October 3, 2008Date of Patent: October 11, 2011Assignee: Advanced Technologies And Regenerative Medicine, LLCInventors: David C. Colter, Anna Gosiewska