Patents Assigned to ADVANCED TECHNOLOGIES & REGENERATIVE MEDICINE, LLC
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Publication number: 20140271778Abstract: Provided are therapeutic implants comprising renal tissue encapsulated within a polymer bead. Also disclosed are methods for treating a disease state in a subject comprising implanting within said subject a therapeutic implant comprising renal tissue encapsulated within a polymer bead. Also provided are methods for making a therapeutic implant comprising: providing renal tissue; mixing the renal tissue with a solution comprising a polymer, thereby forming a tissue-polymer suspension; extruding the tissue-polymer suspension into an bead-forming solution, thereby forming a therapeutic implant comprising beads of said polymer within which the renal tissue is encapsulated.Type: ApplicationFiled: April 14, 2014Publication date: September 18, 2014Applicant: Advanced Technologies and Regenerative Medicine LLCInventors: Charito S. Buensucceso, David C. Colter, Brian C. Kramer, Agnieszka Seyda
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Publication number: 20140248326Abstract: Provided are therapeutic implants comprising renal tissue encapsulated within a polymer bead. Also disclosed are methods for treating a disease state in a subject comprising implanting within said subject a therapeutic implant comprising renal tissue encapsulated within a polymer bead. Also provided are methods for making a therapeutic implant comprising: providing renal tissue; mixing the renal tissue with a solution comprising a polymer, thereby forming a tissue-polymer suspension; extruding the tissue-polymer suspension into an bead-forming solution, thereby forming a therapeutic implant comprising beads of said polymer within which the renal tissue is encapsulated.Type: ApplicationFiled: May 16, 2014Publication date: September 4, 2014Applicant: Advanced Technologies and Regenerative Medicine LLCInventors: Charito S. Buensucceso, David C. Colter, Brian C. Kramer, Agnieszka Seyda
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Patent number: 8734527Abstract: Provided are therapeutic implants comprising renal tissue encapsulated within a polymer bead. Also disclosed are methods for treating a disease state in a subject comprising implanting within said subject a therapeutic implant comprising renal tissue encapsulated within a polymer bead. Also provided are methods for making a therapeutic implant comprising: providing renal tissue; mixing the renal tissue with a solution comprising a polymer, thereby forming a tissue-polymer suspension; extruding the tissue-polymer suspension into an bead-forming solution, thereby forming a therapeutic implant comprising beads of said polymer within which the renal tissue is encapsulated.Type: GrantFiled: December 17, 2008Date of Patent: May 27, 2014Assignee: Advanced Technologies and Regenerative Medicine, LLCInventors: Charito S. Buensuceso, David C. Colter, Brian C. Kramer, Agnieszka Seyda
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Publication number: 20130309222Abstract: We have disclosed affinity peptides toward infliximab. More specifically we have disclosed an affinity biomatrix where the affinity peptide is covalently attached to a biocompatible, biodegradable polymer. The affinity biomatrix is useful in preparing controlled release devices for infliximab.Type: ApplicationFiled: May 17, 2012Publication date: November 21, 2013Applicant: Advanced Technologies and Regenerative Medicine, LLCInventors: Daphne Ann Salick Ryan, John Kehoe, John Wheeler, Chunlin Yang, Abla Creasey
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Publication number: 20130302283Abstract: This invention encompasses methods, pharmaceutical compositions, and kits for modulating (e.g. reducing) the production of pro-inflammatory mediators involved in the pathology of a lung disease, disorder, and/or injury in a patient having the lung disease, disorder, and/or injury. The invention also encompasses methods, pharmaceutical compositions, and kits for inhibiting the production of pro-inflammatory mediators involved in the pathology of a lung disease, disorder, and/or injury in a patient having the lung disease, disorder, and/or injury. In one embodiment, the umbilical cord tissue-derived cells are isolated from human umbilical cord tissue substantially free of blood, are capable of self-renewal and expansion in culture, lack the production of CD117 or CD45, and do not express hTERT or telomerase.Type: ApplicationFiled: May 14, 2012Publication date: November 14, 2013Applicant: Advanced Technologies and Regenerative Medicine, LLCInventor: Anthony J. Kihm
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Publication number: 20130288225Abstract: A method of separating blood by providing a horizontal substrate having a plurality of oxygen plasma-treated polypropylene pillars extending from the surface of a polypropylene film, depositing a whole blood sample on an upper surface of the substrate, collecting red blood cells on the upper surface of the pillars and permitting remaining components of said whole blood sample to flow downward and through the pillars.Type: ApplicationFiled: April 27, 2012Publication date: October 31, 2013Applicants: AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH, ADVANCED TECHNOLOGIES & REGENERATIVE MEDICINE, LLCInventors: Noha Elmouelhi, Sriram Natarajan, Kevin Cooper, Murty Vyakarnam, Chee Tiong Lim, Emma Kim Luong-Van, Isabel Rodriguez, Hong Yee Low, Audrey Yoke Yee Ho
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Publication number: 20130267880Abstract: A blood clotting substrate and device which has a plurality of oxygen plasma-treated polypropylene pillars extending from the surface of a polypropylene film.Type: ApplicationFiled: April 6, 2012Publication date: October 10, 2013Applicants: Agency for Science Technology and Research, Advanced Technologies & Regenerative Medicine, LLCInventors: Emma Kim Luong-Van, Isabel Rodriguez, Hong Yee Low, Audrey Yoke Yee Ho, Sriram Natarajan, Noha Elmouelhi, Kevin Cooper, Murty Vyakarnam, Chee Tiong Lim
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Publication number: 20130266761Abstract: Synthetic polymer substrates comprising a hierarchical surface structure of multiple domes and multiple pillars on said domes, wherein said substrate is a synthetic polymer film, said domes have diameters in the range from about 5 ?m to about 400 ?m, heights in the range from about 2.5 ?m and about 500 ?m, and said pillars have diameters in the range from about 20 nm to about 5 ?m and aspect ratios of from about 2 to about 50, and methods of making and using them.Type: ApplicationFiled: April 6, 2012Publication date: October 10, 2013Applicants: Agency for Science Technology and Research, Advanced Technologies & Regenerative Medicine, LLCInventors: Audrey Yoke Yee Ho, Isabel Rodriguez, Hong Yee Low, Emma Kim Luong-Van, Sriram Natarajan, Noha Elmouelhi, Kevin Cooper, Chee Tiong Lim
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Patent number: 8518390Abstract: This invention relates to methods of treating stroke by intranasal administration of umbilical cord tissue-derived cells, which are isolated from mammalian umbilical cord tissue substantially free of blood or expanded in culture from a cell isolated from mammalian umbilical cord tissue substantially free of blood, are capable of self-renewal and expansion in culture, and do not produce CD117 and/or telomerase. The methods of the invention regenerate, repair and improve neural tissue and improve behavior and neurological function in stroke patients.Type: GrantFiled: July 15, 2011Date of Patent: August 27, 2013Assignee: Advanced Technologies and Regenerative Medicine, LLCInventors: Brian C. Kramer, Anthony J. Kihm
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Publication number: 20130190201Abstract: The invention relates to methods for detecting allogeneic therapeutic cells (such as human umbilical cord tissue-derived cells (hUTC)) in blood. The methods includes the steps of identifying one or more one or more markers positive for allogeneic therapeutic cells (e.g. hUTC) and one or more markers positive for human peripheral blood mononuclear cells (PBMC); providing a blood sample from a patient that has been treated with allogeneic therapeutic cells (e.g. hUTC), analyzing the sample using an assay method to detect one or more markers positive for PBMC and one or more markers positive for allogeneic therapeutic cells (e.g. hUTC); and distinguishing between the PBMC and one or more markers positive for allogeneic therapeutic cells (e.g. hUTC). In one embodiment, the cells are hUTC and the markers positive of hUTC include CD10 and/or CD13 and the one or more markers positive for PBMC includes CD45.Type: ApplicationFiled: December 20, 2012Publication date: July 25, 2013Applicant: Advanced Technologies and Regenerative Medicine, LLCInventor: Advanced Technologies and Regenerative Medicine, LLC
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Patent number: 8491883Abstract: This invention relates to methods of treating amyotrophic lateral sclerosis. In particular, the invention provides for methods of treating amyotrophic lateral sclerosis by administering umbilical cord tissue-derived cells, an effective amount of a substantially homogenous population of umbilical cord tissue-derived cells or a pharmaceutical composition comprising umbilical cord tissue-derived cells to a patient.Type: GrantFiled: February 14, 2011Date of Patent: July 23, 2013Assignee: Advanced Technologies and Regenerative Medicine, LLCInventors: Anna Gosiewska, Alexander M. Harmon, Anthony J. Kihm, Carri H. Fang, Sridevi Dhanaraj
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Publication number: 20130157368Abstract: We have disclosed an induced pluripotent stem cell and the method of preparing the induced pluripotent stem cell from a human kidney-derived cell. More particularly, we have disclosed a human kidney-derived iPS cell which may be differentiated into cells of ectoderm, mesoderm, and endoderm lineages.Type: ApplicationFiled: December 20, 2011Publication date: June 20, 2013Applicant: Advanced Technologies and Regenerative Medicine, LLCInventors: Charito Buensuceso, Agnieszka Seyda, David C. Colter, Sridevi Dhanaraj, Brian C. Kramer, Jason Elliot Ekert, Amanda Lynn Kauffman
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Publication number: 20130157365Abstract: We have disclosed an induced pluripotent stem cell and the method of preparing the induced pluripotent stem cell from a human umbilical cord tissue-derived cell. More particularly, we have disclosed a human umbilical cord tissue-derived iPS cell which may be differentiated into cells of ectoderm, mesoderm, and endoderm lineages.Type: ApplicationFiled: December 20, 2011Publication date: June 20, 2013Applicant: Advanced Technologies and Regenerative Medicine, LLCInventors: Charito Buensuceso, Agnieszka Seyda, David C. Colter, Sridevi Dhanaraj, Brian C. Kramer
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Publication number: 20130065305Abstract: An isolated mammalian internal mammary artery-derived cell is disclosed. Furthermore, methods of isolating the mammalian internal mammary artery-derived cell are disclosed. The cell is useful in tissue engineering technologies, specifically in vascular tissue engineering.Type: ApplicationFiled: November 8, 2012Publication date: March 14, 2013Applicant: Advanced Technologies and Regenerative Medicine, LLCInventor: Advanced Technologies and Regenerative Medicin
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Patent number: 8361459Abstract: Cells derived from postpartum tissue such as the umbilical cord and placenta, and methods for their use to regenerate, repair, and improve neural tissue, and to improve behavior and neurological function in stroke patients are disclosed.Type: GrantFiled: January 29, 2010Date of Patent: January 29, 2013Assignee: Advanced Technologies and Regenerative Medicine, LLCInventors: Darin J. Messina, Sanjay K. Mistry, L. S. Klaudyne Hong, Brian C. Kramer, Michael J. Romanko, Anna Gosiewska
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Publication number: 20130022585Abstract: Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.Type: ApplicationFiled: September 6, 2012Publication date: January 24, 2013Applicant: Advanced Technologies and Regenerative Medicine, LLCInventors: DARIN J. MESSINA, Sanjay Mistry, Alexander M. Harmon, Ian Ross Harris, Anthony J. Kihm, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
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Publication number: 20130005829Abstract: Novel semi-crystalline, epsilon-caprolactone-rich block copolymers of epsilon-caprolactone and p-dioxanone for long term absorbable medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, and other medical devices. Also disclosed are compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease.Type: ApplicationFiled: October 14, 2011Publication date: January 3, 2013Applicant: Advanced Technologies and Regenerative Medicine, LLC.Inventors: Dennis D. Jamiolkowski, Sasa Andjelic, Modesto Erneta
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Publication number: 20120315251Abstract: Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.Type: ApplicationFiled: November 15, 2010Publication date: December 13, 2012Applicant: Advanced Technologies and Regenerative Medicine, LLCInventors: Ian Ross HARRIS, Darin J. Messina, Anthony J. Kihm, Agnieszka Seyda, David C. Colter
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Publication number: 20120315698Abstract: Provided are methods for sterilizing a material comprising a biologically-active agent comprising irradiating said material with ionizing radiation at a dose of about 5 kGy to about 25 kGy while maintaining said material in an atmosphere comprising at least 95% by volume inert gas and at a temperature of about 4° C. or lower. Also provided are sterilized materials comprising a biologically-active agent, wherein said materials exhibit substantially the same amount of biological activity as a non-sterilized control.Type: ApplicationFiled: June 8, 2012Publication date: December 13, 2012Applicant: Advanced Technologies and Regenerative Medicine LLCInventors: ALEXANDER M. HARMON, LAURA J. BROWN, CHARLES J. BUCKLE, FREDERICK HALPERIN, STANKO BODNAR
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Patent number: 8323972Abstract: An isolated mammalian internal mammary artery-derived cell is disclosed. Furthermore, methods of isolating the mammalian internal mammary artery-derived cell are disclosed. The cell is useful in tissue engineering technologies, specifically in vascular tissue engineering.Type: GrantFiled: September 20, 2010Date of Patent: December 4, 2012Assignee: Advanced Technologies and Regenerative Medicine, LLCInventors: David C. Colter, Charito Buensuceso, Christian C. Kazanecki, Anna Gosiewska