Patents Assigned to Adverum Biotechnologies, Inc.
  • Compositions and methods for enhanced gene expression
    Patent number: 11773406
    Abstract: The present disclosure provides polynucleotide cassettes, expression vectors and methods for the expression of a gene in mammalian cells.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: October 3, 2023
    Assignee: Adverum Biotechnologies, Inc.
    Inventor: Annahita Keravala
  • COMPOSITIONS AND METHODS FOR ENHANCED GENE EXPRESSION
    Publication number: 20230257777
    Abstract: The present disclosure provides polynucleotide cassettes, expression vectors and methods for the expression of a gene in mammalian cells.
    Type: Application
    Filed: April 26, 2023
    Publication date: August 17, 2023
    Applicant: Adverum Biotechnologies, Inc.
    Inventor: Annahita Keravala
  • Variant AAV capsids for intravitreal delivery
    Patent number: 11510950
    Abstract: Provided are variant adeno-associated virus (AAV) capsid proteins and recombinant AAV virions having one or more variant AAV capsid proteins. Also provided are compositions and methods for the use of the recombinant AAV virions, such as for the treatment or prophylaxis of a disease or disorder.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: November 29, 2022
    Assignee: ADVERUM BIOTECHNOLOGIES, INC.
    Inventors: Annahita Keravala, Diana Cepeda, Mehdi Gasmi
  • Mutant viral capsid libraries and related systems and methods
    Patent number: 11427931
    Abstract: Provided are mutant viral capsid cell libraries, individual cells of such libraries, systems, vectors, and methods for generating the cell libraries, and methods of use thereof to screen for mutant viral capsids with desired characteristics.
    Type: Grant
    Filed: January 23, 2020
    Date of Patent: August 30, 2022
    Assignee: Adverum Biotechnologies, Inc.
    Inventors: Christopher Chavez, Mehdi Gasmi, Annahita Keravala, Thomas W. Chalberg
  • Compositions and methods for enhanced gene expression
    Patent number: 11352644
    Abstract: The present disclosure provides polynucleotide cassettes, expression vectors, and methods for the expression of a gene in mammalian cells.
    Type: Grant
    Filed: August 20, 2020
    Date of Patent: June 7, 2022
    Assignee: Adverum Biotechnologies, Inc.
    Inventor: Annahita Keravala
  • Compositions and methods for enhanced gene expression in cone cells
    Patent number: 11248214
    Abstract: The present disclosure provides polynucleotide cassettes, expression vectors and methods for the expression of a gene in cone cells.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: February 15, 2022
    Assignees: Adverum Biotechnologies, Inc., University of Washington
    Inventors: Thomas W. Chalberg, Jr., Jay Neitz, Maureen Neitz
  • Modified AAV capsids and uses thereof
    Patent number: 11192925
    Abstract: The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein that binds heparan sulfate proteoglycans, where the AAV virions exhibit greater infectivity of retinal cells, altered tropism and/or the ability to bind and cross the inner limiting membrane following intravitreal injection. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: December 7, 2021
    Assignee: Adverum Biotechnologies, Inc.
    Inventor: Annahita Keravala
  • Compositions and methods for intravitreal delivery of polynucleotides to retinal cones
    Patent number: 11021519
    Abstract: Methods and compositions are provided for intravitreally delivering a polynucleotide to cone photoreceptors. Aspects of the methods include injecting a recombinant adeno-associated virus comprising a polynucleotide of interest into the vitreous of the eye. These methods and compositions find particular use in treating ocular disorders associated with cone dysfunction and/or death.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: June 1, 2021
    Assignees: Adverum Biotechnologies, Inc., University of Washington
    Inventors: Thomas W. Chalberg, Jr., Jay Neitz, Maureen Neitz
  • Mutant viral capsid libraries and related systems and methods
    Patent number: 10584328
    Abstract: Provided are mutant viral capsid cell libraries, individual cells of such libraries, systems, vectors, and methods for generating the cell libraries, and methods of use thereof to screen for mutant viral capsids with desired characteristics.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: March 10, 2020
    Assignee: Adverum Biotechnologies, Inc.
    Inventors: Christopher Chavez, Mehdi Gasmi, Annahita Keravala, Thomas W. Chalberg
  • GENE THERAPY FOR THE TREATMENT OF ALDEHYDE DEHYDROGENASE DEFICIENCY
    Publication number: 20190160187
    Abstract: A vector comprising a promoter operably linked to a nucleic acid sequence encoding human aldehyde dehydrogenase, as well as a composition comprising the vector and method of using the vector to treat aldehyde dehydrogenase deficiency, or to prevent or treat a disease characterized by aldehyde dehydrogenase deficiency.
    Type: Application
    Filed: July 26, 2017
    Publication date: May 30, 2019
    Applicants: Cornell University, Adverum Biotechnologies, Inc.
    Inventors: Mehdi Gasmi, Ronald G. Crystal, Odelya E. Pagovich
  • Compositions and methods for enhanced gene expression in cone cells
    Patent number: 10000741
    Abstract: The present disclosure provides polynucleotide cassettes, expression vectors and methods for the expression of a gene in cone cells.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: June 19, 2018
    Assignees: Adverum Biotechnologies, Inc., University of Washington
    Inventors: Thomas W. Chalberg, Jay Neitz, Maureen Neitz