Patents Assigned to Aeolus Sciences, Inc.
  • SYNTHESIS AND FORMULATIONS OF PORPHYRIN COMPOUNDS
    Publication number: 20160333019
    Abstract: Provided herein, inter alia, are methods of synthesizing and formulating porphyrins, including manganese containing porphyrins. Also provided herein are pharmaceutical compositions and crystals of porphyrins achieved using the methods described herein.
    Type: Application
    Filed: May 19, 2016
    Publication date: November 17, 2016
    Applicant: Aeolus Sciences, Inc.
    Inventors: Jason Brittain, Chris Stanley, Alexander Kolchinski, Mahmoud Mirmehrabi, Duane Bell
  • Substituted porphyrins
    Patent number: 9289434
    Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: March 22, 2016
    Assignees: Aeolus Sciences, Inc., National Jewish Health, Duke University
    Inventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polivina Jolicia F. Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
  • Substituted porphyrins
    Patent number: 8946202
    Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: February 3, 2015
    Assignees: Aeolus Sciences, Inc., National Jewish Health, Duke University
    Inventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polvina Jolicia Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
  • Cancer therapy
    Patent number: 8765729
    Abstract: The present invention relates, in general, to cancer therapy, and, in particular, to a method of preventing or treating cancer using low molecular weight antioxidants (e.g., mimetics of superoxide dismutase (SOD)) as the active agent or as a chemo- and/or radio-protectant. The invention also relates to compounds and compositions suitable for use in such a method.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: July 1, 2014
    Assignees: Aeolus Sciences, Inc., Duke University, National Jewish Medical and Research Center
    Inventors: James D. Crapo, Brian J. Day, Ines Batinic-Haberle, Richard Gammans, Zeljko Vusjaskovic
  • SUBSTITUTED PORPHYRINS
    Publication number: 20120214780
    Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
    Type: Application
    Filed: April 26, 2012
    Publication date: August 23, 2012
    Applicants: AEOLUS SCIENCES, INC., DUKE UNIVERSITY, NATIONAL JEWISH HEALTH
    Inventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polivina Jolicia F. Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
  • Substituted porphyrins
    Patent number: 8217026
    Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
    Type: Grant
    Filed: September 17, 2010
    Date of Patent: July 10, 2012
    Assignees: Aeolus Sciences, Inc., National Jewish Health, Duke University
    Inventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polvina Jolicia F. Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
  • Oxidant Scavengers for Treatment of Diabetes or Use in Transplantation or Induction of Immune Tolerance
    Publication number: 20110105452
    Abstract: The present invention relates, in one embodiment, to a method of preventing or treating diabetes using low molecular weight antioxidants. In a further embodiment, the invention relates to a method of protecting and/or enhancing viability of cells/tissues/organs during isolation (harvesting), preservation, expansion and/or transplantation. In yet another embodiment, the present invention relates to a method of inducing immune tolerance. The invention also relates to compounds and compositions suitable for use in such methods.
    Type: Application
    Filed: November 8, 2010
    Publication date: May 5, 2011
    Applicants: Aeolus Sciences, Inc., National Jewish Medical and Research Center, University of Colorado Health Sciences Center
    Inventors: Jon D. Piganelli, Kathryn Haskins, Sonia C. Flores, James D. Crapo, Brian J. day, Ronald G. Gill, Richard Gammans, Manisha Patel
  • OXIDANT SCAVENGERS FOR TREATMENT OF DIABETES OR USE IN TRANSPLANTATION OR INDUCTION OF IMMUNE TOLERANCE
    Publication number: 20080085883
    Abstract: The present invention relates, in one embodiment, to a method of preventing or treating diabetes using low molecular weight antioxidants. In a further embodiment, the invention relates to a method of protecting and/or enhancing viability of cells/tissues/organs during isolation (harvesting), preservation, expansion and/or transplantation. In yet another embodiment, the present invention relates to a method of inducing immune tolerance. The invention also relates to compounds and compositions suitable for use in such methods.
    Type: Application
    Filed: September 19, 2007
    Publication date: April 10, 2008
    Applicants: AEOLUS SCIENCES, INC., National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Children's Hospital of Pittsburgh
    Inventors: Jon PIGANELLI, Kathryn HASKINS, Sonia FLORES, James CRAPO, Brian DAY, Ronald GILL, Richard GAMMANS, Manisha PATEL
  • CANCER THERAPY
    Publication number: 20070149498
    Abstract: The present invention relates, in general, to cancer therapy, and, in particular, to a method of preventing or treating cancer using low molecular weight antioxidants (e.g., mimetics of superoxide dismutase (SOD)) as the active agent or as a chemo- and/or radio-protectant. The invention also relates to compounds and compositions suitable for use in such a method.
    Type: Application
    Filed: November 9, 2006
    Publication date: June 28, 2007
    Applicants: Aeolus Sciences, Inc., National Jewish Medical and Research Center, Duke University
    Inventors: James Crapo, Brian Day, Ines Batinic-Haberle, Richard Gammans, Zeljko Vusjaskovic
  • Substituted porphyrins
    Patent number: 7189707
    Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
    Type: Grant
    Filed: January 23, 2003
    Date of Patent: March 13, 2007
    Assignees: National Jewish Medical Research Center, Duke University, Aeolus Sciences, Inc.
    Inventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polivina Jolicia F. Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle