Patents Assigned to Aerami Therapeutics, Inc.
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Patent number: 11833291Abstract: An aerosolization system includes a container that is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator includes a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.Type: GrantFiled: July 27, 2022Date of Patent: December 5, 2023Assignee: Aerami Therapeutics, Inc.Inventors: John S. Patton, Ryan S. Patton, Mei-chang Kuo, Yehuda Ivri
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Patent number: 11786676Abstract: A method is described for supplying a metered amount of a liquid medicament to an aerosolizing device. The method utilizes a dispenser comprising an elongate dispenser body having a proximal end and a tip at a distal end through which a liquid medicament is dispensed. The dispenser further comprises a dispensing mechanism that operates to dispense a metered quantity of the liquid medicament from the tip each time the dispenser body is compressed. The dispenser is grasped with one hand such that the fingers wrap around the dispenser body, with the thumb closest to the proximal end and the last finger closest to the tip. The tip is inserted into an opening of an inhaler and the elongate body is forced toward the tip to cause the dispenser body to compress, thereby operating the dispensing mechanism and causing a metered quantity of the liquid medicament to eject into the inhaler.Type: GrantFiled: September 17, 2018Date of Patent: October 17, 2023Assignee: Aerami Therapeutics, Inc.Inventors: Ryan S. Patton, John S. Patton, Mei-chang Kuo, Yehuda Ivri
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Patent number: 11426536Abstract: Liquid drug cartridges and an associated inhaler are used to deliver one more separate doses of an aerosolized liquid drug. A cartridge includes a container for storing the liquid drug, an end cap having an ejection opening, a filter element, and a piston that is repositionable relative to the container to selectively eject a volume of liquid drug from the ejection opening. The filter element filters the liquid drug prior to ejection from the ejection opening. The liquid drug cartridge can be coupled with an inhaler that includes an aerosol generator. The aerosol generator includes a vibratable membrane onto which the liquid drug is ejected. The liquid drug is aerosolized by the vibration of the membrane for inhalation by a user.Type: GrantFiled: April 29, 2019Date of Patent: August 30, 2022Assignee: AERAMI THERAPEUTICS, INC.Inventors: Benjamin Stedman, Jim Fink, Lisa Molloy, Matt Sander
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Patent number: 11400241Abstract: An aerosolization system includes a container that is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator includes a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.Type: GrantFiled: November 15, 2019Date of Patent: August 2, 2022Assignee: AERAMI THERAPEUTICS, INC.Inventors: John S. Patton, Ryan S. Patton, Mei-chang Kuo, Yehuda Ivri
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Patent number: 11285275Abstract: Self-puncturing liquid drug cartridges and an associated inhaler are used to deliver one or more separate doses of an aerosolized liquid drug. A cartridge includes a needle assembly coupled to a drug container. The needle assembly includes a hollow needle and is reconfigurable from a first configuration to a second configuration upon insertion of the cartridge into the inhaler. In the first configuration, the hollow needle does not extend into the container. In the second configuration, the hollow needle extends into the container. The inhaler includes an aerosol generator that includes a vibratable membrane that aerosolizes liquid drug ejected from the cartridge for inhalation by a patient.Type: GrantFiled: February 28, 2020Date of Patent: March 29, 2022Assignee: Aerami Therapeutics, Inc.Inventors: Benjamin Stedman, Jim Fink, Lisa Molloy
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Patent number: 11273271Abstract: In one aspect, embodiments of the present invention provide an aerosolization device for ensuring proper delivery of an aerosolized medication to a user's respiratory system. The aerosolization device may include a conduit, an aerosol generator, a restrictor disposed within the conduit, and an indicator mechanism. The conduit may include a mouthpiece end by which a user may cause inspiratory flow through the conduit. The aerosol generator may include a vibratable mesh. The restrictor may define a plurality of apertures disposed along an outer periphery of the restrictor configured to provide an increase in pressure differential that varies with an inspiratory flow rate within the conduit and to provide a relatively laminar flow downstream of the restrictor compared to upstream of the restrictor. The indicator mechanism may indicate to a user a state of a parameter of the inspiratory flow relative to a predefined desired range.Type: GrantFiled: August 7, 2017Date of Patent: March 15, 2022Assignee: Aerami Therapeutics, Inc.Inventors: Jim Fink, Lisa Molloy, Ronan MacLoughlin, Claire Elizabeth Lillis, Michael Joseph Casey, John Matthew Mullins, Kieran James Hyland, Joseph Martin Grehan
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Patent number: 11096990Abstract: Liquid formulations of insulin that contain physically and chemically stable insulin but do not contain preservatives or stabilizers are provided. The formulations also lack surfactants. The formulations are useful for various modes of delivery including pulmonary delivery.Type: GrantFiled: October 23, 2018Date of Patent: August 24, 2021Assignee: AERAMI THERAPEUTICS, INC.Inventors: Blaine Bueche, Mei-Chang Kuo, John Patton, Matthew Sander
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Patent number: 10857313Abstract: Embodiments provide aerosolization device for providing aerosolized medicament to user. The aerosolization device includes conduit, aerosol generator, fluid receiving chamber, restrictor within the conduit, and indicator mechanism. Conduit has an inner wall and a mouthpiece end for causing an inspiratory flow. Aerosol generator includes a vibratable mesh laterally offset from the inner wall. Fluid receiving chamber receives liquid medicament. At least a portion of chamber is tapered such that liquid medicament is directed onto vibratable mesh for aerosolization. Restrictor defines a plurality of apertures that provide increases in pressure differential that vary with inspiratory flow rate within conduit and provide relatively laminar flow downstream of restrictor. Indicator mechanism indicates a state of flow parameters relative to a predefined range. Aerosol generator is configured to aerosolize at least a portion of liquid medicament only when flow parameters of the inspiratory flow are within range.Type: GrantFiled: June 18, 2015Date of Patent: December 8, 2020Assignee: Aerami Therapeutics, Inc.Inventors: Jim Fink, Lisa Molloy, Ronan MacLoughlin, Claire Elizabeth Lillis, Michael Joseph Casey, John Matthew Mullins, Kieran James Hyland, Joseph Martin Grehan, Niall Scott Smith
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Patent number: 10842951Abstract: Liquid formulations of insulin that contain physically and chemically stable insulin but do not contain preservatives or stabilizers are provided. The formulations also lack surfactants. The formulations are useful for various modes of delivery including pulmonary delivery.Type: GrantFiled: October 23, 2018Date of Patent: November 24, 2020Assignee: Aerami Therapeutics, Inc.Inventors: Blaine Bueche, Mei-Chang Kuo, John Patton, Matthew Sander
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Patent number: 10744282Abstract: One embodiment describes an insulin formulation that is specifically adapted for aerosolization. The formulation comprises a major amount of water and a minor amount of insulin. Further, the formulation is preservative free, without meta-cresol, cresol or phenol, to permit the formulation to be aerosolized using a vibrating aperture plate without substantial foaming of the insulin formulation.Type: GrantFiled: August 21, 2018Date of Patent: August 18, 2020Assignee: Aerami Therapeutics, Inc.Inventors: John S. Patton, Ryan S. Patton, Mei-chang Kuo, Yehuda Ivri
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Patent number: 10610651Abstract: Self-puncturing liquid drug cartridges and an associated inhaler are used to deliver one or more separate doses of an aerosolized liquid drug. A cartridge includes a needle assembly coupled to a drug container. The needle assembly includes a hollow needle and is reconfigurable from a first configuration to a second configuration upon insertion of the cartridge into the inhaler. In the first configuration, the hollow needle does not extend into the container. In the second configuration, the hollow needle extends into the container. The inhaler includes an aerosol generator that includes a vibratable membrane that aerosolizes liquid drug ejected from the cartridge for inhalation by a patient.Type: GrantFiled: June 5, 2015Date of Patent: April 7, 2020Assignee: Aerami Therapeutics, Inc.Inventors: Benjamin Stedman, Jim Fink, Lisa Molloy