Abstract: An apparatus for the collection of samples of exhaled air during normal respiration, comprising a flow generator, an orally insertable exhalation air receiver, and a device for isolating the nasal airways, wherein the apparatus further comprises: a sensor for detecting a change in a parameter representing the change from inhalation to exhalation and to transmit said change as a signal; a control unit adapted to receive said signal and to control said device for isolating the nasal airways; wherein the flow generator is connected to or integrated with the exhalation air receiver.

Abstract: A miniaturised electrochemical sensor for detection of a component in a gas is provided. The sensor comprises a reference electrode, a counter electrode and a structure comprising a plurality of passages delineated by walls extending along the passages. A working electrode covers the walls of the structure and a layer of an ionomer covers at least part of the working electrode along the walls of the structure. The layer of ionomer is in ion conducting contact with the electrodes. The disclosure further relates to a method of fabricating a miniaturised electrochemical sensor and to a device for measuring content of NO in exhaled breath comprising such a miniaturised electrochemical sensor.

Abstract: A method for at least partially inserting a plug into a hole, said method comprising the steps of a) providing a at least one substrate with at least one hole wherein said at least one hole has a largest dimension of from 1 ?m to 300 ?m, b) providing a piece of material, wherein said piece of material has a larger dimension than said at least one hole, c) pressing said piece of material against the hole with a tool so that a plug is formed, wherein at least a part of said piece of material is pressed into said hole, d) removing the tool from the piece of material. There is further disclosed a plugged hole manufactured with the method. One advantage of an embodiment is that an industrially available wire bonding technology can be used to seal various cavities. The existing wire bonding technology makes the plugging fast and cheap.

Abstract: A handle component of the present invention into which atmospheric air is inhaled and breath is exhaled in the analysis of breath comprises inhalation holes, an inhalation inlet, an inhalation path, a breath discharge component, and an exhalation path. The inhalation holes are disposed near the tube connected for conducting exhaled breath to an analysis device main body for analyzing this breath, and are holes through which atmospheric air is inhaled into the interior of the handle component. The inhalation inlet is a place where the atmospheric air inhaled from the inhalation holes is sent into the body. The inhalation path is disposed between the inhalation inlet and the inhalation holes. The breath discharge component is a place where breath discharged from the body is taken in. The exhalation path is disposed between the breath discharge component and the tube.

Abstract: The flow rate of a gaseous sample of exhaled breath through an analytical device is controlled by a pump, and in certain embodiments two pumps. Placement of the analyte sensor in a secondary stream branching off of the primary stream through the device offers further control over the manner, duration, and quantity of the breath that is placed in contact with the sensor.

Abstract: There is provided an analysis device comprising a gas phase and a liquid phase and at least one sensor, said sensor having at least one point where an analyte is detected, said at least point being in contact with the liquid phase, characterized in that the device comprises a membrane with a first and a second side, which membrane is in contact with the gas phase on at least a part of one side of the membrane and which membrane is in contact with the liquid phase on at least a part of the other side of the membrane, wherein the membrane comprises openings, and wherein the largest possible distance between any two openings in the membrane is larger than the distance between the membrane and the point where an analyte is detected, moreover there is provided a method for analyzing an analyte in a gas phase.

Abstract: A handheld, small but accurate and reliable device for diagnostic NO measurements using a NO sensor, where the parameters governing the taking of the sample are different from the parameters optimal for the accuracy of said NO sensor. By temporarily storing a portion of the exhaled air, and feeding this to the sensor at a flow rate adapted to the NO sensor, the accuracy and sensitivity of a system/method involving NO sensors, in particular electrochemical NO sensors, can be increased. The method for diagnostic NO measurements comprises steps for controlling the inhalation of NO free air, as well as the exhalation, both by built-in means and by audible and/or visual feedback to the patient.

Abstract: The function of a measuring device can be tested using a healthy person as an external control, provided that this person fulfils certain criteria and that particular method steps are adhered to.

Abstract: A handheld, small but accurate and reliable device for diagnostic NO measurements using a NO sensor, where the parameters governing the taking of the sample are different from the parameters optimal for the accuracy of said NO sensor. By temporarily storing a portion of the exhaled air, and feeding this to the sensor at a flow rate adapted to the NO sensor, the accuracy and sensitivity of a system/method involving NO sensors, in particular electrochemical NO sensors, can be increased. The method for diagnostic NO measurements comprises steps for controlling the inhalation of NO free air, as well as the exhalation, both by built-in means and by audible and/or visual feedback to the patient.

Abstract: A handheld, small but accurate and reliable device for diagnostic NO measurements using a NO sensor, where the parameters governing the taking of the sample are different from the parameters optimal for the accuracy of said NO sensor I described. By temporarily storing a portion of the exhaled air, and feeding this to the sensor at a flow rate adapted to the NO sensor, the accuracy and sensitivity of a system/method involving NO sensors, in particular electrochemical NO sensors, can be increased. The method for diagnostic NO measurements comprises steps for controlling the inhalation of NO free air, as well as the exhalation, both by built-in means and by audible and/or visual feedback to the patient.

Abstract: The present invention relates to the field of gas measurements, andmore specifically to the field of testing the measuring function of a measuring device (7) for gas measurements, the measuring device (7) including a gas sensor (9) generating at least one output signal. The method includes connecting at least one simulation signal to the measuring device (7) and/or feeding a gas mixture to the measuring device wherein the magnitude of the concentration of a gas to be measured in the gas mixture is known. The invention also relates to a simulation device (1) for connection to the measuring device (7) for gas measurements when testing the measuring function of the measuring device (7). The simulation device (1) generates at least one simulation signal which can attain at least one signal level, wherein a certain signal value corresponds to a certain gas concentration.

Abstract: A diaphragm device for a check valves is provided. The diaphragm device comprises a diaphragm, adapted to cover at least one orifice, and an operation device, adapted to enable movement of the diaphragm substantially along a length axis of the orifice. The operation device comprises at least one first operation organ and at least one second operation organ. The first and second operation organ in turn each comprises a first portion, and a second portion. The first portion of the first operation organ is adapted to be connected to a check valve housing, and the second portion of the first operation organ is connected to the second portion of the second operation organ. Furthermore the first portion of the second operation organ is connected to the diaphragm and the second portion of the second operation organ is connected to the second portion of the first operation organ.

Abstract: A method for at least partially inserting a plug into a hole, said method comprising the steps of a) providing a at least one substrate with at least one hole wherein said at least one hole has a largest dimension of from 1 ?m to 300 ?m, b) providing a piece of material, wherein said piece of material has a larger dimension than said at least one hole, c) pressing said piece of material against the hole with a tool so that a plug is formed, wherein at least a part of said piece of material is pressed into said hole, d) removing the tool from the piece of material. There is further disclosed a plugged hole manufactured with the method. One advantage of an embodiment is that an industrially available wire bonding technology can be used to seal various cavities. The existing wire bonding technology makes the plugging fast and cheap.