Abstract: The invention relates to drug substance preparations, pharmaceutical compositions and dosage forms containing (R)-(?)-2-(2-fluoro-4-biphenylyl) propionic acid as the active pharmaceutical ingredient, and limited amounts of specific product-related and process-related impurities.
Type:
Grant
Filed:
July 31, 2009
Date of Patent:
February 18, 2014
Assignee:
Aesica Pharmaceuticals Limited
Inventors:
Gaylen M. Zentner, James C. McRea, Mark S. Williams, Stephen J. Martin, Norman T. Smith, Catriona A. Oare
Abstract: There is described a process for the manufacture of a racemic 2-aryl propionic acid compound, or a pharmaceutically acceptable salt thereof, which comprises reacting the S- or R-enantiomer of the corresponding 2-aryl propionic acid compound with a base.