Patents Assigned to Afferent Pharmaceuticals, Inc.
  • DIAMINOPYRIMIDINE P2X3 AND P2X2/3 RECEPTOR MODULATORS FOR USE IN THE TREATMENT OF COUGH
    Publication number: 20180280388
    Abstract: Methods for treating cough, chronic cough and urges to cough associated with respiratory diseases with a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are as defined herein.
    Type: Application
    Filed: September 23, 2016
    Publication date: October 4, 2018
    Applicant: Afferent Pharmaceuticals, Inc.
    Inventors: Anthony P. Ford, Kathleen Sereda Glaub, Michael M. Kitt, Steven Smith
  • SUBSTITUTED PYRIMIDINES FOR TREATMENT OF ACUTE COUGH, CHRONIC COUGH AND URGE TO COUGH
    Publication number: 20170326142
    Abstract: Methods for treating cough, chronic cough and urges to cough associated with respiratory diseases with a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are as defined herein.
    Type: Application
    Filed: August 1, 2017
    Publication date: November 16, 2017
    Applicant: Afferent Pharmaceuticals. Inc.
    Inventors: Anthony P. FORD, Bruce G. MCCARTHY
  • Substituted pyrimidines for treatment of a cough selected from chronic pathological cough, sub-acute pathological cough, acute pathological cough, neuronal hypersensitivity underlying chronic cough, neuronal hypersensitivity underlying sub-acute cough and neuronal hypersensitivity underlying acute cough
    Patent number: 9724346
    Abstract: Methods for treating cough, chronic cough and urges to cough associated with respiratory diseases with a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are as defined herein.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: August 8, 2017
    Assignee: Afferent Pharmaceuticals Inc.
    Inventors: Anthony P. Ford, Bruce G. McCarthy
  • METHODS AND COMPOSITIONS FOR TREATING DISEASES AND CONDITIONS
    Publication number: 20170151241
    Abstract: Provided herein include methods and compositions for treating diseases or conditions. In some embodiments provided are methods for treating one or more diseases or conditions selected from the group consisting of hypertension, heart failure, dyspnea, and sleep apnea. In certain embodiments provided are methods that include administering a compound of formula (I) as disclosed herein. In some embodiments provided are methods that include administering a P2X3 and/or a P2X2/3 receptor antagonist.
    Type: Application
    Filed: July 2, 2015
    Publication date: June 1, 2017
    Applicant: Afferent Pharmaceuticals Inc.
    Inventors: Anthony P. FORD, Julian PATON
  • SUBSTITUTED PYRIMIDINES FOR TREATMENT OF ACUTE COUGH, CHRONIC COUGH AND URGE TO COUGH
    Publication number: 20160263112
    Abstract: Methods for treating cough, chronic cough and urges to cough associated with respiratory diseases with a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are as defined herein.
    Type: Application
    Filed: February 2, 2016
    Publication date: September 15, 2016
    Applicant: Afferent Pharmaceuticals, Inc.
    Inventors: Anthony P. FORD, Bruce G. MCCARTHY
  • Substituted pyrimidines for treatment of acute cough, chronic cough and urge to cough
    Patent number: 9284279
    Abstract: Methods for treating cough, chronic cough and urges to cough associated with respiratory diseases with a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are as defined herein.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: March 15, 2016
    Assignee: Afferent Pharmaceuticals, Inc.
    Inventors: Anthony P. Ford, Bruce G. McCarthy